FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4294043553> ?p ?o ?g. }

• W4294043553 endingPage "e0269887" @default.
• W4294043553 startingPage "e0269887" @default.
• W4294043553 abstract "Investigating the 3D structures and rearrangements of organelles within a single cell is critical for better characterizing cellular function. Imaging approaches such as soft X-ray tomography have been widely applied to reveal a complex subcellular organization involving multiple inter-organelle interactions. However, 3D segmentation of organelle instances has been challenging despite its importance in organelle characterization. Here we propose an intensity-based post-processing tool to identify and separate organelle instances. Our tool separates sphere-like (insulin vesicle) and columnar-shaped organelle instances (mitochondrion) based on the intensity of raw tomograms, semantic segmentation masks, and organelle morphology. We validate our tool using synthetic tomograms of organelles and experimental tomograms of pancreatic β-cells to separate insulin vesicle and mitochondria instances. As compared to the commonly used connected regions labeling, watershed, and watershed + Gaussian filter methods, our tool results in improved accuracy in identifying organelles in the synthetic tomograms and an improved description of organelle structures in β-cell tomograms. In addition, under different experimental treatment conditions, significant changes in volumes and intensities of both insulin vesicle and mitochondrion are observed in our instance results, revealing their potential roles in maintaining normal β-cell function. Our tool is expected to be applicable for improving the instance segmentation of other images obtained from different cell types using multiple imaging modalities." @default.
• W4294043553 created "2022-09-01" @default.
• W4294043553 creator A5001845207 @default.
• W4294043553 creator A5007745108 @default.
• W4294043553 creator A5017648766 @default.
• W4294043553 creator A5021293751 @default.
• W4294043553 creator A5024375259 @default.
• W4294043553 creator A5028082830 @default.
• W4294043553 creator A5028845140 @default.
• W4294043553 creator A5033952648 @default.
• W4294043553 creator A5046875759 @default.
• W4294043553 creator A5075077010 @default.
• W4294043553 creator A5089374061 @default.
• W4294043553 date "2022-09-01" @default.
• W4294043553 modified "2023-10-18" @default.
• W4294043553 title "An intensity-based post-processing tool for 3D instance segmentation of organelles in soft X-ray tomograms" @default.
• W4294043553 cites W145510193 @default.
• W4294043553 cites W1552632109 @default.
• W4294043553 cites W1966852147 @default.
• W4294043553 cites W1973687723 @default.
• W4294043553 cites W1997664070 @default.
• W4294043553 cites W2025818287 @default.
• W4294043553 cites W2031900290 @default.
• W4294043553 cites W2036004254 @default.
• W4294043553 cites W2036372349 @default.
• W4294043553 cites W2039276913 @default.
• W4294043553 cites W2042809741 @default.
• W4294043553 cites W2046011778 @default.
• W4294043553 cites W2053486382 @default.
• W4294043553 cites W2063238582 @default.
• W4294043553 cites W2063322369 @default.
• W4294043553 cites W2086485894 @default.
• W4294043553 cites W2109218888 @default.
• W4294043553 cites W2119244755 @default.
• W4294043553 cites W2122264788 @default.
• W4294043553 cites W2132629607 @default.
• W4294043553 cites W2137287407 @default.
• W4294043553 cites W2140309276 @default.
• W4294043553 cites W2144627501 @default.
• W4294043553 cites W2145803225 @default.
• W4294043553 cites W2162348697 @default.
• W4294043553 cites W2164092512 @default.
• W4294043553 cites W2167279371 @default.
• W4294043553 cites W2520303620 @default.
• W4294043553 cites W2529448830 @default.
• W4294043553 cites W2567580014 @default.
• W4294043553 cites W2617667835 @default.
• W4294043553 cites W2782443304 @default.
• W4294043553 cites W2789504060 @default.
• W4294043553 cites W2803631955 @default.
• W4294043553 cites W2892053315 @default.
• W4294043553 cites W2910040256 @default.
• W4294043553 cites W2941713117 @default.
• W4294043553 cites W2965372978 @default.
• W4294043553 cites W3027419479 @default.
• W4294043553 cites W3028517845 @default.
• W4294043553 cites W3046892796 @default.
• W4294043553 cites W3094339716 @default.
• W4294043553 cites W3110682852 @default.
• W4294043553 cites W3112952736 @default.
• W4294043553 cites W3193415673 @default.
• W4294043553 cites W3199973852 @default.
• W4294043553 cites W4200590554 @default.
• W4294043553 cites W4211082830 @default.
• W4294043553 cites W4221017207 @default.
• W4294043553 cites W4251431888 @default.
• W4294043553 cites W4255124627 @default.
• W4294043553 doi "https://doi.org/10.1371/journal.pone.0269887" @default.
• W4294043553 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36048824" @default.
• W4294043553 hasPublicationYear "2022" @default.
• W4294043553 type Work @default.
• W4294043553 citedByCount "2" @default.
• W4294043553 countsByYear W42940435532022 @default.
• W4294043553 countsByYear W42940435532023 @default.
• W4294043553 crossrefType "journal-article" @default.
• W4294043553 hasAuthorship W4294043553A5001845207 @default.
• W4294043553 hasAuthorship W4294043553A5007745108 @default.
• W4294043553 hasAuthorship W4294043553A5017648766 @default.
• W4294043553 hasAuthorship W4294043553A5021293751 @default.
• W4294043553 hasAuthorship W4294043553A5024375259 @default.
• W4294043553 hasAuthorship W4294043553A5028082830 @default.
• W4294043553 hasAuthorship W4294043553A5028845140 @default.
• W4294043553 hasAuthorship W4294043553A5033952648 @default.
• W4294043553 hasAuthorship W4294043553A5046875759 @default.
• W4294043553 hasAuthorship W4294043553A5075077010 @default.
• W4294043553 hasAuthorship W4294043553A5089374061 @default.
• W4294043553 hasBestOaLocation W42940435531 @default.
• W4294043553 hasConcept C104317684 @default.
• W4294043553 hasConcept C120665830 @default.
• W4294043553 hasConcept C121332964 @default.
• W4294043553 hasConcept C131934819 @default.
• W4294043553 hasConcept C153180895 @default.
• W4294043553 hasConcept C154945302 @default.
• W4294043553 hasConcept C155432671 @default.
• W4294043553 hasConcept C163716698 @default.
• W4294043553 hasConcept C168240541 @default.
• W4294043553 hasConcept C186060115 @default.
• W4294043553 hasConcept C41008148 @default.

• next