FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4294057170> ?p ?o ?g. }

• W4294057170 abstract "The uterine myometrium expands and maintains contractile quiescence before parturition. While the steroid hormone progesterone blocks labor, the role of progesterone signaling in myometrial expansion remains elusive. This study investigated the myometrial functions of the progesterone receptor, PGR. Pgr ablation in mouse smooth muscle leads to subfertility, oviductal embryo retention, and impaired myometrial adaptation to pregnancy. While gross morphology between mutant and control uteri are comparable, mutant uteri manifest a decrease of 76.6% oxytocin-stimulated contractility in a pseudopregnant context with a reduced expression of intracellular calcium homeostasis genes including Pde5a and Plcb4. At mid-pregnancy, the mutant myometrium exhibits discontinuous myofibers and disarrayed extracellular matrix at the conceptus site. Transcriptome of the mutant mid-pregnant uterine wall manifests altered muscle and extracellular matrix profiles and resembles that of late-pregnancy control tissues. A survey of PGR occupancy, H3K27ac histone marks, and chromatin looping annotates cis-acting elements that may direct gene expression of mid-pregnancy uteri for uterine remodeling. Further analyses suggest that major muscle and matrix regulators Myocd and Ccn2 and smooth muscle building block genes are PGR direct downstream targets. Cataloging enhancers that are topologically associated with progesterone downstream genes reveals distinctive patterns of transcription factor binding motifs in groups of enhancers and identifies potential regulatory partners of PGR outside its occupying sites. Finally, conserved correlations are found between estimated PGR activities and RNA abundance of downstream muscle and matrix genes in human myometrial tissues. In summary, PGR is pivotal to direct the molecular program for the uterus to remodel and support pregnancy." @default.
• W4294057170 created "2022-09-01" @default.
• W4294057170 creator A5006593112 @default.
• W4294057170 creator A5042367509 @default.
• W4294057170 creator A5044775173 @default.
• W4294057170 creator A5066908162 @default.
• W4294057170 creator A5069048623 @default.
• W4294057170 creator A5077909338 @default.
• W4294057170 creator A5081438934 @default.
• W4294057170 creator A5083143789 @default.
• W4294057170 date "2022-08-19" @default.
• W4294057170 modified "2023-10-14" @default.
• W4294057170 title "Myometrial progesterone receptor determines a transcription program for uterine remodeling and contractions during pregnancy" @default.
• W4294057170 cites W1587915032 @default.
• W4294057170 cites W1596182601 @default.
• W4294057170 cites W1963928942 @default.
• W4294057170 cites W1968478522 @default.
• W4294057170 cites W1970078194 @default.
• W4294057170 cites W1977503450 @default.
• W4294057170 cites W1992940238 @default.
• W4294057170 cites W2007506415 @default.
• W4294057170 cites W2025594421 @default.
• W4294057170 cites W2025995094 @default.
• W4294057170 cites W2036897871 @default.
• W4294057170 cites W2055706903 @default.
• W4294057170 cites W2062333446 @default.
• W4294057170 cites W2064770755 @default.
• W4294057170 cites W2073141218 @default.
• W4294057170 cites W2075874898 @default.
• W4294057170 cites W2077499143 @default.
• W4294057170 cites W2080755065 @default.
• W4294057170 cites W2082236421 @default.
• W4294057170 cites W2082559087 @default.
• W4294057170 cites W2090392605 @default.
• W4294057170 cites W2107569607 @default.
• W4294057170 cites W2109835072 @default.
• W4294057170 cites W2113495229 @default.
• W4294057170 cites W2114104545 @default.
• W4294057170 cites W2118739051 @default.
• W4294057170 cites W2123696077 @default.
• W4294057170 cites W2124985265 @default.
• W4294057170 cites W2130265677 @default.
• W4294057170 cites W2131723050 @default.
• W4294057170 cites W2131845382 @default.
• W4294057170 cites W2132943628 @default.
• W4294057170 cites W2133102933 @default.
• W4294057170 cites W2134907628 @default.
• W4294057170 cites W2137385355 @default.
• W4294057170 cites W2138207763 @default.
• W4294057170 cites W2154233762 @default.
• W4294057170 cites W2157709564 @default.
• W4294057170 cites W2158217645 @default.
• W4294057170 cites W2169456326 @default.
• W4294057170 cites W2170551349 @default.
• W4294057170 cites W2171808845 @default.
• W4294057170 cites W2179438025 @default.
• W4294057170 cites W2239920470 @default.
• W4294057170 cites W2313594428 @default.
• W4294057170 cites W2398323469 @default.
• W4294057170 cites W2481029670 @default.
• W4294057170 cites W2549182437 @default.
• W4294057170 cites W2609407516 @default.
• W4294057170 cites W2732244647 @default.
• W4294057170 cites W2796617153 @default.
• W4294057170 cites W2926726148 @default.
• W4294057170 cites W2951471154 @default.
• W4294057170 cites W2964849163 @default.
• W4294057170 cites W2981362235 @default.
• W4294057170 cites W2994772464 @default.
• W4294057170 cites W3004564966 @default.
• W4294057170 cites W3006680891 @default.
• W4294057170 cites W3042279204 @default.
• W4294057170 cites W3092293897 @default.
• W4294057170 cites W3097708269 @default.
• W4294057170 cites W3135641278 @default.
• W4294057170 cites W3151808042 @default.
• W4294057170 cites W3215145762 @default.
• W4294057170 cites W3217586528 @default.
• W4294057170 cites W4220863044 @default.
• W4294057170 cites W4283319100 @default.
• W4294057170 doi "https://doi.org/10.1093/pnasnexus/pgac155" @default.
• W4294057170 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36120506" @default.
• W4294057170 hasPublicationYear "2022" @default.
• W4294057170 type Work @default.
• W4294057170 citedByCount "2" @default.
• W4294057170 countsByYear W42940571702023 @default.
• W4294057170 crossrefType "journal-article" @default.
• W4294057170 hasAuthorship W4294057170A5006593112 @default.
• W4294057170 hasAuthorship W4294057170A5042367509 @default.
• W4294057170 hasAuthorship W4294057170A5044775173 @default.
• W4294057170 hasAuthorship W4294057170A5066908162 @default.
• W4294057170 hasAuthorship W4294057170A5069048623 @default.
• W4294057170 hasAuthorship W4294057170A5077909338 @default.
• W4294057170 hasAuthorship W4294057170A5081438934 @default.
• W4294057170 hasAuthorship W4294057170A5083143789 @default.
• W4294057170 hasBestOaLocation W42940571701 @default.
• W4294057170 hasConcept C121608353 @default.
• W4294057170 hasConcept C126322002 @default.
• W4294057170 hasConcept C134018914 @default.
• W4294057170 hasConcept C189165786 @default.

• next