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- W4294057178 abstract "Throughout the COVID-19 pandemic, control of transmission has been repeatedly thwarted by the emergence of variants of concern (VOC) and their geographic spread. Key questions remain regarding effective means of minimizing the impact of VOC, in particular the feasibility of containing them at source, in light of global interconnectedness. By analysing a stochastic transmission model of COVID-19, we identify the appropriate monitoring requirements that make containment at source feasible. Specifically, precise risk assessment informed primarily by epidemiological indicators (e.g. accumulated hospitalization or mortality reports), is unlikely prior to VOC escape. Consequently, decision makers will need to make containment decisions without confident severity estimates. In contrast, successfully identifying and containing variants via genomic surveillance is realistic, provided sequence processing and dissemination is prompt." @default.
- W4294057178 created "2022-09-01" @default.
- W4294057178 creator A5025998541 @default.
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- W4294057178 date "2022-08-19" @default.
- W4294057178 modified "2023-10-01" @default.
- W4294057178 title "Containing novel SARS-CoV-2 variants at source is possible with high-intensity sequencing" @default.
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- W4294057178 doi "https://doi.org/10.1093/pnasnexus/pgac159" @default.
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