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- W4294124929 abstract "Aspirin protects against atherothrombosis while increasing the risk of major bleeding. Although it is widely used to prevent cardiovascular disease (CVD), its benefit does not outweigh its risk for primary CVD prevention in large population settings. The recent United States Preventive Services Task Force guidelines on aspirin use to prevent CVD reflect this clinical tradeoff as well as the persistent struggle to define a population that would benefit from prophylactic aspirin therapy. Past clinical trials of primary CVD prevention with aspirin have not included consideration of a biomarker relevant to aspirin’s mechanism of action, platelet inhibition. This approach is at odds with the paradigm used in other key areas of pharmacological CVD prevention, including antihypertensive and statin therapy, which combine cardiovascular risk assessment with the measurement of mechanistic biomarkers (eg, blood pressure and LDL [low-density lipoprotein]-cholesterol). Reliable methods for quantifying platelet activity, including light transmission aggregometry and platelet transcriptomics, exist and should be considered to identify individuals at elevated cardiovascular risk due to a hyperreactive platelet phenotype. Therefore, we propose a new, platelet-guided approach to the study of prophylactic aspirin therapy. We think that this new approach will reveal a population with hyperreactive platelets who will benefit most from primary CVD prevention with aspirin and usher in a new era of precision-guided antiplatelet therapy." @default.
- W4294124929 created "2022-09-02" @default.
- W4294124929 creator A5065965634 @default.
- W4294124929 creator A5075943424 @default.
- W4294124929 date "2022-10-01" @default.
- W4294124929 modified "2023-10-14" @default.
- W4294124929 title "Aspirin for the Primary Prevention of Cardiovascular Disease: Time for a Platelet-Guided Approach" @default.
- W4294124929 cites W1239246082 @default.
- W4294124929 cites W1480025546 @default.
- W4294124929 cites W1480729244 @default.
- W4294124929 cites W1586781424 @default.
- W4294124929 cites W1964910597 @default.
- W4294124929 cites W1972566357 @default.
- W4294124929 cites W1974627888 @default.
- W4294124929 cites W1975554781 @default.
- W4294124929 cites W1976505948 @default.
- W4294124929 cites W1977991745 @default.
- W4294124929 cites W1979438759 @default.
- W4294124929 cites W1985491210 @default.
- W4294124929 cites W2003076495 @default.
- W4294124929 cites W2010288704 @default.
- W4294124929 cites W2012214760 @default.
- W4294124929 cites W2025039880 @default.
- W4294124929 cites W2025342289 @default.
- W4294124929 cites W2026648151 @default.
- W4294124929 cites W2027436660 @default.
- W4294124929 cites W2029663570 @default.
- W4294124929 cites W2030923262 @default.
- W4294124929 cites W2034340681 @default.
- W4294124929 cites W2039156905 @default.
- W4294124929 cites W2039527993 @default.
- W4294124929 cites W2043666180 @default.
- W4294124929 cites W2045171794 @default.
- W4294124929 cites W2048570075 @default.
- W4294124929 cites W2049884419 @default.
- W4294124929 cites W2065121216 @default.
- W4294124929 cites W2066903303 @default.
- W4294124929 cites W2073923734 @default.
- W4294124929 cites W2090609282 @default.
- W4294124929 cites W2092652272 @default.
- W4294124929 cites W2096300961 @default.
- W4294124929 cites W2097657831 @default.
- W4294124929 cites W2100089051 @default.
- W4294124929 cites W2102191497 @default.
- W4294124929 cites W2137408480 @default.
- W4294124929 cites W2138279617 @default.
- W4294124929 cites W2138597449 @default.
- W4294124929 cites W2138875549 @default.
- W4294124929 cites W2141084316 @default.
- W4294124929 cites W2149137596 @default.
- W4294124929 cites W2149678323 @default.
- W4294124929 cites W2164089346 @default.
- W4294124929 cites W2165387925 @default.
- W4294124929 cites W2188507800 @default.
- W4294124929 cites W2330187990 @default.
- W4294124929 cites W2335453170 @default.
- W4294124929 cites W2344216384 @default.
- W4294124929 cites W2509570419 @default.
- W4294124929 cites W2567601689 @default.
- W4294124929 cites W2594104733 @default.
- W4294124929 cites W2766257307 @default.
- W4294124929 cites W2768267412 @default.
- W4294124929 cites W2768798424 @default.
- W4294124929 cites W2782191937 @default.
- W4294124929 cites W2792316622 @default.
- W4294124929 cites W2793043942 @default.
- W4294124929 cites W2884727639 @default.
- W4294124929 cites W2888108651 @default.
- W4294124929 cites W2892288854 @default.
- W4294124929 cites W2899755710 @default.
- W4294124929 cites W2900034165 @default.
- W4294124929 cites W2907453767 @default.
- W4294124929 cites W2914972362 @default.
- W4294124929 cites W2921012991 @default.
- W4294124929 cites W2921295166 @default.
- W4294124929 cites W2963783710 @default.
- W4294124929 cites W2996072467 @default.
- W4294124929 cites W3010084936 @default.
- W4294124929 cites W3017024756 @default.
- W4294124929 cites W3122226502 @default.
- W4294124929 cites W3170079927 @default.
- W4294124929 cites W3177093043 @default.
- W4294124929 cites W3196464088 @default.
- W4294124929 cites W3197233987 @default.
- W4294124929 cites W3215774169 @default.
- W4294124929 cites W4210347219 @default.
- W4294124929 cites W4220663054 @default.
- W4294124929 cites W4238968220 @default.
- W4294124929 cites W4245466284 @default.
- W4294124929 cites W4283722350 @default.
- W4294124929 cites W4296154158 @default.
- W4294124929 cites W4301683752 @default.
- W4294124929 doi "https://doi.org/10.1161/atvbaha.122.318020" @default.
- W4294124929 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36047408" @default.
- W4294124929 hasPublicationYear "2022" @default.
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