FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4294142602> ?p ?o ?g. }

• W4294142602 endingPage "4250" @default.
• W4294142602 startingPage "4250" @default.
• W4294142602 abstract "Background: Human epidermal growth factor receptor 2 (HER2)-low tumor is a new entity defined as HER2 immunohistochemistry (IHC) 1+ or 2+/fluorescence in situ hybridization (FISH)-negative. We aimed to evaluate whether HER2 mRNA levels tested by quantitative reverse transcriptase-polymerase chain reaction (qRT-PCR) could better define HER2-low tumors. Patients and methods: Consecutive breast cancer patients with hormonal receptor-positive, HER2-negative diseases, and HER2 mRNA results were included. Clinicopathologic features, HER2 mRNA expression level, and prognosis were compared among HER2 0, 1+ and 2+/FISH− groups. Concordance of the HER2 category between qRT-PCR and IHC/FISH was analyzed for each group. Results: 2296 patients were included: 368 (16.0%) HER2 0, 911 (39.7%) 1+, and 1017 (44.3%) 2+/FISH− tumors. HER2 1+ cases shared similarities with HER2 0 tumors in terms of clinicopathologic features (all p > 0.05), whereas IHC 2+/FISH− cases were less often non-IDC (p = 0.045), node-negative (p = 0.044), and Ki-67 < 14% (p <0.001). The mRNA expression was similar between HER2 0 and 1+ cases (p = 0.063), and both were lower than 2+/FISH− cases (p < 0.001). A poor concordance rate was found between IHC/FISH and qRT-PCR for HER2 0 and HER2-low cases (Cohen’s kappa 0.126, p < 0.001). No survival difference was observed among these groups, whether stratified by HER2 IHC/FISH status or mRNA level (all p > 0.05). Conclusions: HER2 1+ cases had similar clinicopathological features to HER2 0 breast cancers, and both were different from HER2 2+/FISH− cases. HER2 mRNA levels were comparable between HER2 0 and 1+ tumors, and both were significantly lower than IHC 2+/FISH− tumors. Neither IHC nor qRT-PCR may be optimal to quantify HER2-low expression, especially for HER2 1+ patients." @default.
• W4294142602 created "2022-09-02" @default.
• W4294142602 creator A5025255741 @default.
• W4294142602 creator A5037460817 @default.
• W4294142602 creator A5058932226 @default.
• W4294142602 creator A5072445958 @default.
• W4294142602 creator A5073706757 @default.
• W4294142602 date "2022-08-31" @default.
• W4294142602 modified "2023-10-18" @default.
• W4294142602 title "Can HER2 1+ Breast Cancer Be Considered as HER2-Low Tumor? A Comparison of Clinicopathological Features, Quantitative HER2 mRNA Levels, and Prognosis among HER2-Negative Breast Cancer" @default.
• W4294142602 cites W1996778928 @default.
• W4294142602 cites W2017553956 @default.
• W4294142602 cites W2037013151 @default.
• W4294142602 cites W2117242541 @default.
• W4294142602 cites W2117775530 @default.
• W4294142602 cites W2118343282 @default.
• W4294142602 cites W2126816162 @default.
• W4294142602 cites W2152494192 @default.
• W4294142602 cites W2157214529 @default.
• W4294142602 cites W2532399819 @default.
• W4294142602 cites W2560406314 @default.
• W4294142602 cites W2596790323 @default.
• W4294142602 cites W2754042392 @default.
• W4294142602 cites W2771728402 @default.
• W4294142602 cites W2777699715 @default.
• W4294142602 cites W2806209829 @default.
• W4294142602 cites W2913744681 @default.
• W4294142602 cites W2947181781 @default.
• W4294142602 cites W2953684910 @default.
• W4294142602 cites W2999744434 @default.
• W4294142602 cites W3005585857 @default.
• W4294142602 cites W3006813318 @default.
• W4294142602 cites W3008591390 @default.
• W4294142602 cites W3018222852 @default.
• W4294142602 cites W3116741170 @default.
• W4294142602 cites W3119128530 @default.
• W4294142602 cites W3130200855 @default.
• W4294142602 cites W3134129955 @default.
• W4294142602 cites W3135957253 @default.
• W4294142602 cites W3162334759 @default.
• W4294142602 cites W3179156059 @default.
• W4294142602 cites W4210684267 @default.
• W4294142602 cites W4211032970 @default.
• W4294142602 cites W4212953123 @default.
• W4294142602 cites W4220923708 @default.
• W4294142602 cites W4225141827 @default.
• W4294142602 cites W4229028760 @default.
• W4294142602 doi "https://doi.org/10.3390/cancers14174250" @default.
• W4294142602 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36077795" @default.
• W4294142602 hasPublicationYear "2022" @default.
• W4294142602 type Work @default.
• W4294142602 citedByCount "9" @default.
• W4294142602 countsByYear W42941426022022 @default.
• W4294142602 countsByYear W42941426022023 @default.
• W4294142602 crossrefType "journal-article" @default.
• W4294142602 hasAuthorship W4294142602A5025255741 @default.
• W4294142602 hasAuthorship W4294142602A5037460817 @default.
• W4294142602 hasAuthorship W4294142602A5058932226 @default.
• W4294142602 hasAuthorship W4294142602A5072445958 @default.
• W4294142602 hasAuthorship W4294142602A5073706757 @default.
• W4294142602 hasBestOaLocation W42941426021 @default.
• W4294142602 hasConcept C104317684 @default.
• W4294142602 hasConcept C121608353 @default.
• W4294142602 hasConcept C126322002 @default.
• W4294142602 hasConcept C142724271 @default.
• W4294142602 hasConcept C143998085 @default.
• W4294142602 hasConcept C160798450 @default.
• W4294142602 hasConcept C204232928 @default.
• W4294142602 hasConcept C2777542201 @default.
• W4294142602 hasConcept C2779786085 @default.
• W4294142602 hasConcept C2909208804 @default.
• W4294142602 hasConcept C30481170 @default.
• W4294142602 hasConcept C48023723 @default.
• W4294142602 hasConcept C505870484 @default.
• W4294142602 hasConcept C530470458 @default.
• W4294142602 hasConcept C55493867 @default.
• W4294142602 hasConcept C71924100 @default.
• W4294142602 hasConcept C86803240 @default.
• W4294142602 hasConceptScore W4294142602C104317684 @default.
• W4294142602 hasConceptScore W4294142602C121608353 @default.
• W4294142602 hasConceptScore W4294142602C126322002 @default.
• W4294142602 hasConceptScore W4294142602C142724271 @default.
• W4294142602 hasConceptScore W4294142602C143998085 @default.
• W4294142602 hasConceptScore W4294142602C160798450 @default.
• W4294142602 hasConceptScore W4294142602C204232928 @default.
• W4294142602 hasConceptScore W4294142602C2777542201 @default.
• W4294142602 hasConceptScore W4294142602C2779786085 @default.
• W4294142602 hasConceptScore W4294142602C2909208804 @default.
• W4294142602 hasConceptScore W4294142602C30481170 @default.
• W4294142602 hasConceptScore W4294142602C48023723 @default.
• W4294142602 hasConceptScore W4294142602C505870484 @default.
• W4294142602 hasConceptScore W4294142602C530470458 @default.
• W4294142602 hasConceptScore W4294142602C55493867 @default.
• W4294142602 hasConceptScore W4294142602C71924100 @default.
• W4294142602 hasConceptScore W4294142602C86803240 @default.
• W4294142602 hasFunder F4320321001 @default.
• W4294142602 hasFunder F4320321881 @default.
• W4294142602 hasFunder F4320321885 @default.

• next