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• W4294151218 abstract "Herein, we report a new click-activated prodrug, CA4V, and a bioorthogonal nanoreactor, CA4V/ZIF-90@TzCOF@Apt, which consists of a ZIF-90 core, tetrazine-based covalent organic framework (COF) shells and an aptamer polymer coating. When targeting a tumor, the acid-causing collapse of ZIF-90 initiates a nanoconfined bioorthogonal reaction in defined COF cages, which boosts the click efficiency of CA4V activation and therapeutic effects in vivo." @default.
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• W4294151218 date "2022-01-01" @default.
• W4294151218 modified "2023-10-09" @default.
• W4294151218 title "COF-based nanoreactors for click-activated prodrug delivery and precise anti-vascular therapy" @default.
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• W4294151218 doi "https://doi.org/10.1039/d2cc03931a" @default.
• W4294151218 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36102676" @default.
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