Matches in SemOpenAlex for { <https://semopenalex.org/work/W4294152364> ?p ?o ?g. }
Showing items 1 to 100 of
100
with 100 items per page.
- W4294152364 abstract "2-Halogenatedphenyl benzoxazole-5-carboxylic acids with mono-halogen (chloro, bromo and fluoro) substituted at ortho-, meta- and para-positions on the phenyl ring were designed and synthesized based on significance of presence of halogen in increasing number of marketed halogenated drugs and importance of benzoxazoles. These 2-alogenatedphenylbenzoxazole-5-carboxylic acids and their methyl esters were screened for anti-inflammatory activity, and cytotoxicity. 2-(3-Chlorophenyl)benzoxaole-5-carboxylic acid (6b) exhibited significant anti-inflammatory activity with IC50 values of 0.103 mM almost equivalent to the standard drug ibuprofen (0.101 mM). 2-(4-Chlorophenyl)benzoxaole-5-carboxylic acid (6c) showed excellent cytotoxic activity against 22Rv1 cells (human prostate carcinoma epithelial cell lines) with IC50 value of 1.54 μM better than that of standard drug doxorubicin having IC50 value of 2.32 μM. More importantly, the selectivity index of this potential molecule was found to be 57.74. Molecular docking analysis resulted in good binding interactions of these compounds with their respective biochemical targets viz. Cyclooxygenase-2 and aldo-keto reductase IC3." @default.
- W4294152364 created "2022-09-02" @default.
- W4294152364 creator A5046646817 @default.
- W4294152364 creator A5055440487 @default.
- W4294152364 creator A5066086779 @default.
- W4294152364 creator A5067884164 @default.
- W4294152364 creator A5071302238 @default.
- W4294152364 creator A5073771747 @default.
- W4294152364 creator A5086817785 @default.
- W4294152364 date "2022-09-26" @default.
- W4294152364 modified "2023-09-26" @default.
- W4294152364 title "Synthesis and Biological Evaluation of 2‐(Halophenyl)benzoxazole‐5‐Carboxylic Acids as Potential Anti‐Inflammatory and Cytotoxic Agent with Molecular Docking Studies" @default.
- W4294152364 cites W1982024247 @default.
- W4294152364 cites W2007900773 @default.
- W4294152364 cites W2021667633 @default.
- W4294152364 cites W2060347008 @default.
- W4294152364 cites W2062541099 @default.
- W4294152364 cites W2063443576 @default.
- W4294152364 cites W2066255009 @default.
- W4294152364 cites W2084199566 @default.
- W4294152364 cites W2094156804 @default.
- W4294152364 cites W2126748103 @default.
- W4294152364 cites W2334358734 @default.
- W4294152364 cites W2549976854 @default.
- W4294152364 cites W2598400865 @default.
- W4294152364 cites W2790107769 @default.
- W4294152364 cites W2893375819 @default.
- W4294152364 cites W2902241204 @default.
- W4294152364 cites W2939572266 @default.
- W4294152364 cites W2998499172 @default.
- W4294152364 cites W3015770209 @default.
- W4294152364 cites W3031093253 @default.
- W4294152364 cites W3126742347 @default.
- W4294152364 cites W3128688564 @default.
- W4294152364 cites W3211693933 @default.
- W4294152364 cites W3216505667 @default.
- W4294152364 doi "https://doi.org/10.1002/cbdv.202200489" @default.
- W4294152364 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36050285" @default.
- W4294152364 hasPublicationYear "2022" @default.
- W4294152364 type Work @default.
- W4294152364 citedByCount "0" @default.
- W4294152364 crossrefType "journal-article" @default.
- W4294152364 hasAuthorship W4294152364A5046646817 @default.
- W4294152364 hasAuthorship W4294152364A5055440487 @default.
- W4294152364 hasAuthorship W4294152364A5066086779 @default.
- W4294152364 hasAuthorship W4294152364A5067884164 @default.
- W4294152364 hasAuthorship W4294152364A5071302238 @default.
- W4294152364 hasAuthorship W4294152364A5073771747 @default.
- W4294152364 hasAuthorship W4294152364A5086817785 @default.
- W4294152364 hasConcept C109316439 @default.
- W4294152364 hasConcept C159110408 @default.
- W4294152364 hasConcept C178790620 @default.
- W4294152364 hasConcept C185592680 @default.
- W4294152364 hasConcept C202751555 @default.
- W4294152364 hasConcept C2777752497 @default.
- W4294152364 hasConcept C2778047396 @default.
- W4294152364 hasConcept C2779074116 @default.
- W4294152364 hasConcept C2779944601 @default.
- W4294152364 hasConcept C2780263894 @default.
- W4294152364 hasConcept C41685203 @default.
- W4294152364 hasConcept C46062151 @default.
- W4294152364 hasConcept C55493867 @default.
- W4294152364 hasConcept C71240020 @default.
- W4294152364 hasConcept C71924100 @default.
- W4294152364 hasConcept C98274493 @default.
- W4294152364 hasConceptScore W4294152364C109316439 @default.
- W4294152364 hasConceptScore W4294152364C159110408 @default.
- W4294152364 hasConceptScore W4294152364C178790620 @default.
- W4294152364 hasConceptScore W4294152364C185592680 @default.
- W4294152364 hasConceptScore W4294152364C202751555 @default.
- W4294152364 hasConceptScore W4294152364C2777752497 @default.
- W4294152364 hasConceptScore W4294152364C2778047396 @default.
- W4294152364 hasConceptScore W4294152364C2779074116 @default.
- W4294152364 hasConceptScore W4294152364C2779944601 @default.
- W4294152364 hasConceptScore W4294152364C2780263894 @default.
- W4294152364 hasConceptScore W4294152364C41685203 @default.
- W4294152364 hasConceptScore W4294152364C46062151 @default.
- W4294152364 hasConceptScore W4294152364C55493867 @default.
- W4294152364 hasConceptScore W4294152364C71240020 @default.
- W4294152364 hasConceptScore W4294152364C71924100 @default.
- W4294152364 hasConceptScore W4294152364C98274493 @default.
- W4294152364 hasIssue "10" @default.
- W4294152364 hasLocation W42941523641 @default.
- W4294152364 hasLocation W42941523642 @default.
- W4294152364 hasOpenAccess W4294152364 @default.
- W4294152364 hasPrimaryLocation W42941523641 @default.
- W4294152364 hasRelatedWork W1977213462 @default.
- W4294152364 hasRelatedWork W2010735377 @default.
- W4294152364 hasRelatedWork W2038008830 @default.
- W4294152364 hasRelatedWork W2264709198 @default.
- W4294152364 hasRelatedWork W2486576046 @default.
- W4294152364 hasRelatedWork W2727445327 @default.
- W4294152364 hasRelatedWork W3015036417 @default.
- W4294152364 hasRelatedWork W4221130573 @default.
- W4294152364 hasRelatedWork W4294152364 @default.
- W4294152364 hasRelatedWork W4320494718 @default.
- W4294152364 hasVolume "19" @default.
- W4294152364 isParatext "false" @default.
- W4294152364 isRetracted "false" @default.
- W4294152364 workType "article" @default.