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- W4294169523 abstract "The front cover features colorized SEM image of a bone marrow derived-DC cell (blue) interacting with a NK cell (yellow) from RAG−/− mice. NK cells can rapidly secrete IFN-γ during an infection. However, it is unclear how IFN-γ production is initiated. In this issue, Abdi et al. (pp. 1431–1440) investigated which comes first: IL-12 or IFN-γ? Using purified NK cells cocultured with DCs obtained from cytokine- and cytokine receptor-deficient mice, they measured IFN-γ produced at the single-cell level. The authors demonstrate that IFN-γ production by NK cells is independent of commonly known cytokines, thereby revealing a previously unsuspected pathway for an early source of IFN-γ. These data suggest that, similar to IL-4 production, a small amount of “priming” IFN-γ is needed early to stimulate a large amount later." @default.
- W4294169523 created "2022-09-02" @default.
- W4294169523 date "2022-09-01" @default.
- W4294169523 modified "2023-10-16" @default.
- W4294169523 doi "https://doi.org/10.1002/eji.v52.9" @default.
- W4294169523 hasPublicationYear "2022" @default.
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