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- W4294190706 abstract "The mammalian respiratory system or lung is a tree-like branching structure, and the main site of gas exchange with the external environment. Structurally, the lung is broadly classified into the proximal (or conducting) airways and the distal alveolar region, where the gas exchange occurs. In parallel with the respiratory tree, the pulmonary vasculature starts with large pulmonary arteries that subdivide rapidly ending in capillaries adjacent to alveolar structures to enable gas exchange. The NOTCH signalling pathway plays an important role in lung development, differentiation and regeneration post-injury. Signalling via the NOTCH pathway is mediated through activation of four NOTCH receptors (NOTCH1-4), with each receptor capable of regulating unique biological processes. Dysregulation of the NOTCH pathway has been associated with development and pathophysiology of multiple adult acute and chronic lung diseases. This includes accumulating evidence that alteration of NOTCH3 signalling plays an important role in the development and pathogenesis of chronic obstructive pulmonary disease, lung cancer, asthma, idiopathic pulmonary fibrosis and pulmonary arterial hypertension. Herein, we provide a comprehensive summary of the role of NOTCH3 signalling in regulating repair/regeneration of the adult lung, its association with development of lung disease and potential therapeutic strategies to target its signalling activity." @default.
- W4294190706 created "2022-09-02" @default.
- W4294190706 creator A5045111286 @default.
- W4294190706 creator A5045838760 @default.
- W4294190706 creator A5058022497 @default.
- W4294190706 creator A5060681892 @default.
- W4294190706 creator A5071115670 @default.
- W4294190706 date "2022-01-01" @default.
- W4294190706 modified "2023-09-26" @default.
- W4294190706 title "The emerging role of NOTCH3 receptor signalling in human lung diseases" @default.
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