Matches in SemOpenAlex for { <https://semopenalex.org/work/W4294200512> ?p ?o ?g. }
Showing items 1 to 88 of
88
with 100 items per page.
- W4294200512 endingPage "S244" @default.
- W4294200512 startingPage "S244" @default.
- W4294200512 abstract "Introduction Central glucocorticoid receptor (GR) has been found to play an important role in the interpretation of cognitive abnormalities of posttraumatic stress disorder (PTSD), particularly focused on the extinction failure of fear memory. Potential of using GR antagonist as a pharmacological agent to prevent PTSD-related fear memory disruption is worth investigating. Objectives We aimed to examine whether GR antagonist Mifepristone (RU486) administered before single prolonged stress (SPS) can prevent rats from fear memory extinction impairment. Methods In the present study, SPS was employed in rats to induce a rodent model of PTSD. 60 minutes before SPS, RU486 (20 mg/kg) was administered by intraperitoneal injection. Seven days after SPS, rats received a protocol of behavioral testing to measure their abilities of specific fear memory (by a cue-dependent fear conditioning paradigm) and nonspecific spatial memory (by T-maze). Neurochemically, we measured plasma corticosterone with or without dexamethasone suppression, activation ratio of GR and levels of norepinephrine, dopamine, and serotonin in amygdala, paraventricular nucleus, dorsal and ventral hippocampus. Results Our results found that RU486 exerted protective effects on SPS-induced fear extinction impairment. Corticosterone of SPS-RU486 rats was less suppressed by dexamethasone. GR became less activated in dorsal hippocampus of SPS-RU486 rats. Conclusions The findings supported the utility of GR antagonism in preventing the development of PTSD. Disclosure No significant relationships." @default.
- W4294200512 created "2022-09-02" @default.
- W4294200512 creator A5072541723 @default.
- W4294200512 creator A5073242476 @default.
- W4294200512 date "2022-06-01" @default.
- W4294200512 modified "2023-09-26" @default.
- W4294200512 title "Protective effects of glucocorticoid receptor antagonist Mifepristone on fear memory extinction impairment in a rat model of PTSD" @default.
- W4294200512 doi "https://doi.org/10.1192/j.eurpsy.2022.630" @default.
- W4294200512 hasPublicationYear "2022" @default.
- W4294200512 type Work @default.
- W4294200512 citedByCount "0" @default.
- W4294200512 crossrefType "journal-article" @default.
- W4294200512 hasAuthorship W4294200512A5072541723 @default.
- W4294200512 hasAuthorship W4294200512A5073242476 @default.
- W4294200512 hasBestOaLocation W42942005121 @default.
- W4294200512 hasConcept C101991246 @default.
- W4294200512 hasConcept C126322002 @default.
- W4294200512 hasConcept C134018914 @default.
- W4294200512 hasConcept C15744967 @default.
- W4294200512 hasConcept C16837860 @default.
- W4294200512 hasConcept C169760540 @default.
- W4294200512 hasConcept C169900460 @default.
- W4294200512 hasConcept C170493617 @default.
- W4294200512 hasConcept C185592680 @default.
- W4294200512 hasConcept C199289684 @default.
- W4294200512 hasConcept C2776885963 @default.
- W4294200512 hasConcept C2778122271 @default.
- W4294200512 hasConcept C2778826759 @default.
- W4294200512 hasConcept C2779144063 @default.
- W4294200512 hasConcept C2779234561 @default.
- W4294200512 hasConcept C2780004078 @default.
- W4294200512 hasConcept C2780352252 @default.
- W4294200512 hasConcept C2780401358 @default.
- W4294200512 hasConcept C2780841215 @default.
- W4294200512 hasConcept C2781161787 @default.
- W4294200512 hasConcept C3018842126 @default.
- W4294200512 hasConcept C54355233 @default.
- W4294200512 hasConcept C59493245 @default.
- W4294200512 hasConcept C71315377 @default.
- W4294200512 hasConcept C71924100 @default.
- W4294200512 hasConcept C86803240 @default.
- W4294200512 hasConceptScore W4294200512C101991246 @default.
- W4294200512 hasConceptScore W4294200512C126322002 @default.
- W4294200512 hasConceptScore W4294200512C134018914 @default.
- W4294200512 hasConceptScore W4294200512C15744967 @default.
- W4294200512 hasConceptScore W4294200512C16837860 @default.
- W4294200512 hasConceptScore W4294200512C169760540 @default.
- W4294200512 hasConceptScore W4294200512C169900460 @default.
- W4294200512 hasConceptScore W4294200512C170493617 @default.
- W4294200512 hasConceptScore W4294200512C185592680 @default.
- W4294200512 hasConceptScore W4294200512C199289684 @default.
- W4294200512 hasConceptScore W4294200512C2776885963 @default.
- W4294200512 hasConceptScore W4294200512C2778122271 @default.
- W4294200512 hasConceptScore W4294200512C2778826759 @default.
- W4294200512 hasConceptScore W4294200512C2779144063 @default.
- W4294200512 hasConceptScore W4294200512C2779234561 @default.
- W4294200512 hasConceptScore W4294200512C2780004078 @default.
- W4294200512 hasConceptScore W4294200512C2780352252 @default.
- W4294200512 hasConceptScore W4294200512C2780401358 @default.
- W4294200512 hasConceptScore W4294200512C2780841215 @default.
- W4294200512 hasConceptScore W4294200512C2781161787 @default.
- W4294200512 hasConceptScore W4294200512C3018842126 @default.
- W4294200512 hasConceptScore W4294200512C54355233 @default.
- W4294200512 hasConceptScore W4294200512C59493245 @default.
- W4294200512 hasConceptScore W4294200512C71315377 @default.
- W4294200512 hasConceptScore W4294200512C71924100 @default.
- W4294200512 hasConceptScore W4294200512C86803240 @default.
- W4294200512 hasIssue "S1" @default.
- W4294200512 hasLocation W42942005121 @default.
- W4294200512 hasLocation W42942005122 @default.
- W4294200512 hasOpenAccess W4294200512 @default.
- W4294200512 hasPrimaryLocation W42942005121 @default.
- W4294200512 hasRelatedWork W1969105855 @default.
- W4294200512 hasRelatedWork W1970091690 @default.
- W4294200512 hasRelatedWork W1992533206 @default.
- W4294200512 hasRelatedWork W2010587042 @default.
- W4294200512 hasRelatedWork W2034583712 @default.
- W4294200512 hasRelatedWork W2053795671 @default.
- W4294200512 hasRelatedWork W2078471485 @default.
- W4294200512 hasRelatedWork W2110552899 @default.
- W4294200512 hasRelatedWork W4378346933 @default.
- W4294200512 hasRelatedWork W2103261141 @default.
- W4294200512 hasVolume "65" @default.
- W4294200512 isParatext "false" @default.
- W4294200512 isRetracted "false" @default.
- W4294200512 workType "article" @default.