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- W4294217100 abstract "Bioactivity-guided isolation of Uvaria rufa leaves and Nephelium hypoleucum bark resulted in the successful isolation of nine compounds (1–9) bearing a new polyoxygenated cyclohexene scaffold: zeylenol-6-shikimate (1), (−)-zeylenol (2), microcarpin A (3), uvarigranol F (4), quercetin (5), kaempferol (6), and p-coumaric acid (7) from U. rufa, and epicatechin (8) and cinnamtannin B1 (9) from N. hypoleucum. The structures of the isolated compounds were elucidated using various spectroscopic techniques. All compounds, except for 7, exhibited weak-to-strong TRAIL-resistance-overcoming activity and an increased gastric cancer cell line (AGS) inhibition by 17–32% as compared to the treatment with the compounds alone. Compounds 3 and 9 were studied for their ability to overcome TRAIL resistance using western blot analysis, which indicated that they sensitised AGS cells to apoptosis via both extrinsic and intrinsic pathways by increasing the expression of several proapoptotic proteins (cleaved caspase-3, −8, and −9) and by decreasing the expression of anti-apoptotic protein Bcl-2." @default.
- W4294217100 created "2022-09-02" @default.
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- W4294217100 date "2022-12-01" @default.
- W4294217100 modified "2023-09-23" @default.
- W4294217100 title "New polyoxygenated cyclohexenes isolated from Uvaria rufa and cinnamtannin B1 isolated from Nephelium hypoleucum with TRAIL-resistance-overcoming activity" @default.
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- W4294217100 doi "https://doi.org/10.1016/j.phytol.2022.08.010" @default.
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