FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4294225529> ?p ?o ?g. }

• W4294225529 abstract "Atropine is an essential part of the treatment protocol for equine uveitis. Topical atropine administration has been associated with decreased intestinal motility and abdominal pain in horses. Experimental studies have indicated that frequent dosing is associated with a higher risk than dosing every 6 h. Unfortunately, no quantitative pharmacodynamic data for inhibition of the equine gut are published.Eight standardbred horses were assigned to receive either atropine or saline (control) to be infused over 30 min in a two-treatment cross-over design. Atropine concentrations in plasma were measured using ultra-high-performance liquid chromatography-tandem mass spectrometry. Intestinal motility was measured using borborygmi frequency and electrointestinography (EIG). Experimental data were analyzed using a non-linear mixed effects model. The model was then used to simulate different dosing regimens.Atropine significantly decreased borborygmi response and EIG response. Six horses developed clinical signs of abdominal pain. The pharmacokinetic typical values were 0.31, 1.38, 0.69, and 1.95 L/kg·h for the volumes of the central, the highly perfused, the scarcely perfused compartments, and the total body clearance, respectively. The pharmacodynamic typical values were 0.31 μg/L and 0.6 and 207 nV27 cpm for the plasma concentration at 50% of the maximum response and the maximum response and the baseline of cecal EIG response, respectively. Six different dosing regimens of topical atropine sulfate to the eye (0.4 and 1 mg every hour, every 3 h, and every 6 h) were simulated.The IV PK/PD data coupled with simulations predict that administration of 1 mg of topical atropine sulfate administered to the eye every hour or every 3 h will lead to atropine accumulation in plasma and decreased intestinal myoelectric activity. Administration every 6 h predicted a safe dosing regimen in full-sized horses. Clinical studies would be valuable to confirm the conclusions. For smaller equids and horses put at risk for colic due to othercauses, droplet bottles that deliver 40 μl of 1% atropine sulfate per drop or less may be used to lower the risk further." @default.
• W4294225529 created "2022-09-02" @default.
• W4294225529 creator A5000955066 @default.
• W4294225529 creator A5028004248 @default.
• W4294225529 creator A5032000892 @default.
• W4294225529 creator A5034328234 @default.
• W4294225529 creator A5053869533 @default.
• W4294225529 creator A5061637703 @default.
• W4294225529 creator A5068793995 @default.
• W4294225529 date "2022-09-02" @default.
• W4294225529 modified "2023-10-14" @default.
• W4294225529 title "Plasma atropine concentrations associated with decreased intestinal motility in horses" @default.
• W4294225529 cites W106024502 @default.
• W4294225529 cites W1457315837 @default.
• W4294225529 cites W1507824714 @default.
• W4294225529 cites W165325101 @default.
• W4294225529 cites W1962828954 @default.
• W4294225529 cites W1989465025 @default.
• W4294225529 cites W1997035092 @default.
• W4294225529 cites W2004243189 @default.
• W4294225529 cites W2016986142 @default.
• W4294225529 cites W2017523315 @default.
• W4294225529 cites W2027928922 @default.
• W4294225529 cites W2066261353 @default.
• W4294225529 cites W2070015120 @default.
• W4294225529 cites W2077841704 @default.
• W4294225529 cites W2080254892 @default.
• W4294225529 cites W2083959401 @default.
• W4294225529 cites W2114568594 @default.
• W4294225529 cites W2155965588 @default.
• W4294225529 cites W21619495 @default.
• W4294225529 cites W2164836202 @default.
• W4294225529 cites W2405154413 @default.
• W4294225529 cites W2410398798 @default.
• W4294225529 cites W2735348615 @default.
• W4294225529 cites W2761221630 @default.
• W4294225529 cites W2768349222 @default.
• W4294225529 cites W2794619468 @default.
• W4294225529 cites W2848093881 @default.
• W4294225529 cites W2962360208 @default.
• W4294225529 cites W3022961933 @default.
• W4294225529 cites W3140943668 @default.
• W4294225529 doi "https://doi.org/10.3389/fvets.2022.951300" @default.
• W4294225529 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36118347" @default.
• W4294225529 hasPublicationYear "2022" @default.
• W4294225529 type Work @default.
• W4294225529 citedByCount "1" @default.
• W4294225529 countsByYear W42942255292022 @default.
• W4294225529 crossrefType "journal-article" @default.
• W4294225529 hasAuthorship W4294225529A5000955066 @default.
• W4294225529 hasAuthorship W4294225529A5028004248 @default.
• W4294225529 hasAuthorship W4294225529A5032000892 @default.
• W4294225529 hasAuthorship W4294225529A5034328234 @default.
• W4294225529 hasAuthorship W4294225529A5053869533 @default.
• W4294225529 hasAuthorship W4294225529A5061637703 @default.
• W4294225529 hasAuthorship W4294225529A5068793995 @default.
• W4294225529 hasBestOaLocation W42942255291 @default.
• W4294225529 hasConcept C111113717 @default.
• W4294225529 hasConcept C112705442 @default.
• W4294225529 hasConcept C151730666 @default.
• W4294225529 hasConcept C185592680 @default.
• W4294225529 hasConcept C2775859210 @default.
• W4294225529 hasConcept C2777288759 @default.
• W4294225529 hasConcept C2777397205 @default.
• W4294225529 hasConcept C2780762169 @default.
• W4294225529 hasConcept C3017650105 @default.
• W4294225529 hasConcept C42219234 @default.
• W4294225529 hasConcept C54355233 @default.
• W4294225529 hasConcept C58207958 @default.
• W4294225529 hasConcept C71924100 @default.
• W4294225529 hasConcept C86803240 @default.
• W4294225529 hasConcept C98274493 @default.
• W4294225529 hasConceptScore W4294225529C111113717 @default.
• W4294225529 hasConceptScore W4294225529C112705442 @default.
• W4294225529 hasConceptScore W4294225529C151730666 @default.
• W4294225529 hasConceptScore W4294225529C185592680 @default.
• W4294225529 hasConceptScore W4294225529C2775859210 @default.
• W4294225529 hasConceptScore W4294225529C2777288759 @default.
• W4294225529 hasConceptScore W4294225529C2777397205 @default.
• W4294225529 hasConceptScore W4294225529C2780762169 @default.
• W4294225529 hasConceptScore W4294225529C3017650105 @default.
• W4294225529 hasConceptScore W4294225529C42219234 @default.
• W4294225529 hasConceptScore W4294225529C54355233 @default.
• W4294225529 hasConceptScore W4294225529C58207958 @default.
• W4294225529 hasConceptScore W4294225529C71924100 @default.
• W4294225529 hasConceptScore W4294225529C86803240 @default.
• W4294225529 hasConceptScore W4294225529C98274493 @default.
• W4294225529 hasLocation W42942255291 @default.
• W4294225529 hasLocation W42942255292 @default.
• W4294225529 hasLocation W42942255293 @default.
• W4294225529 hasLocation W42942255294 @default.
• W4294225529 hasLocation W42942255295 @default.
• W4294225529 hasLocation W42942255296 @default.
• W4294225529 hasOpenAccess W4294225529 @default.
• W4294225529 hasPrimaryLocation W42942255291 @default.
• W4294225529 hasRelatedWork W2004325424 @default.
• W4294225529 hasRelatedWork W2021319218 @default.
• W4294225529 hasRelatedWork W2227061539 @default.
• W4294225529 hasRelatedWork W2245370565 @default.
• W4294225529 hasRelatedWork W2594910449 @default.

• next