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- W4294233631 endingPage "1940" @default.
- W4294233631 startingPage "1940" @default.
- W4294233631 abstract "Generating a prion with exogenously produced recombinant prion protein is widely accepted as the ultimate proof of the prion hypothesis. Over the years, a plethora of misfolded recPrP conformers have been generated, but despite their seeding capability, many of them have failed to elicit a fatal neurodegenerative disorder in wild-type animals like a naturally occurring prion. The application of the protein misfolding cyclic amplification technique and the inclusion of non-protein cofactors in the reaction mixture have led to the generation of authentic recombinant prions that fully recapitulate the characteristics of native prions. Together, these studies reveal that recPrP can stably exist in a variety of misfolded conformations and when inoculated into wild-type animals, misfolded recPrP conformers cause a wide range of outcomes, from being completely innocuous to lethal. Since all these recPrP conformers possess seeding capabilities, these results clearly suggest that seeding activity alone is not equivalent to prion activity. Instead, authentic prions are those PrP conformers that are not only heritable (the ability to seed the conversion of normal PrP) but also pathogenic (the ability to cause fatal neurodegeneration). The knowledge gained from the studies of the recombinant prion is important for us to understand the pathogenesis of prion disease and the roles of misfolded proteins in other neurodegenerative disorders." @default.
- W4294233631 created "2022-09-02" @default.
- W4294233631 creator A5032122445 @default.
- W4294233631 creator A5038011017 @default.
- W4294233631 creator A5038699958 @default.
- W4294233631 date "2022-08-31" @default.
- W4294233631 modified "2023-09-26" @default.
- W4294233631 title "Recombinant Mammalian Prions: The “Correctly” Misfolded Prion Protein Conformers" @default.
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