FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4294243669> ?p ?o ?g. }

• W4294243669 abstract "Introduction: Critical-sized long bone defects represent a major therapeutic challenge and current treatment strategies are not without complication. Tissue engineering holds much promise for these debilitating injuries; however, these strategies often fail to successfully translate from rodent studies to the clinical setting. The dog represents a strong model for translational orthopedic studies, however such studies should be optimized in pursuit of the Principle of the 3R's of animal research (replace, reduce, refine). The objective of this study was to refine a canine critical-sized femoral defect model using an angle-stable interlocking nail (AS-ILN) and reduce total animal numbers by performing imaging, biomechanics, and histology on the same cohort of dogs. Methods: Six skeletally mature hounds underwent a 4 cm mid-diaphyseal femoral ostectomy followed by stabilization with an AS-ILN. Dogs were assigned to autograft (n = 3) or negative control (n = 3) treatment groups. At 6, 12, and 18 weeks, healing was quantified by ordinal radiographic scoring and quantified CT. After euthanasia, femurs from the autograft group were mechanically evaluated using an established torsional loading protocol. Femurs were subsequently assessed histologically. Results: Surgery was performed without complication and the AS-ILN provided appropriate fixation for the duration of the study. Dogs assigned to the autograft group achieved radiographic union by 12 weeks, whereas the negative control group experienced non-union. At 18 weeks, median bone and soft tissue callus volume were 9,001 mm3 (range: 4,939-10,061) for the autograft group and 3,469 mm3 (range: 3,085-3,854) for the negative control group. Median torsional stiffness for the operated, autograft treatment group was 0.19 Nm/° (range: 0.19-1.67) and torque at failure was 12.0 Nm (range: 1.7-14.0). Histologically, callus formation and associated endochondral ossification were identified in the autograft treatment group, whereas fibrovascular tissue occupied the critical-sized defect in negative controls. Conclusion: In a canine critical-sized defect model, the AS-ILN and described outcome measures allowed refinement and reduction consistent with the Principle of the 3R's of ethical animal research. This model is well-suited for future canine translational bone tissue engineering studies." @default.
• W4294243669 created "2022-09-02" @default.
• W4294243669 creator A5004333984 @default.
• W4294243669 creator A5011513598 @default.
• W4294243669 creator A5016658297 @default.
• W4294243669 creator A5018898872 @default.
• W4294243669 creator A5027832717 @default.
• W4294243669 creator A5030068339 @default.
• W4294243669 creator A5031188468 @default.
• W4294243669 creator A5049634551 @default.
• W4294243669 creator A5058709659 @default.
• W4294243669 date "2022-09-02" @default.
• W4294243669 modified "2023-10-18" @default.
• W4294243669 title "Angle-stable interlocking nailing in a canine critical-sized femoral defect model for bone regeneration studies: In pursuit of the principle of the 3R’s" @default.
• W4294243669 cites W1776031877 @default.
• W4294243669 cites W1904938007 @default.
• W4294243669 cites W1964517483 @default.
• W4294243669 cites W1971680905 @default.
• W4294243669 cites W1973276259 @default.
• W4294243669 cites W1973707842 @default.
• W4294243669 cites W1974869210 @default.
• W4294243669 cites W1983988008 @default.
• W4294243669 cites W1993887185 @default.
• W4294243669 cites W1994016706 @default.
• W4294243669 cites W2007310752 @default.
• W4294243669 cites W2024261809 @default.
• W4294243669 cites W2024451442 @default.
• W4294243669 cites W2030181985 @default.
• W4294243669 cites W2030509685 @default.
• W4294243669 cites W2033307150 @default.
• W4294243669 cites W2035354085 @default.
• W4294243669 cites W2035605658 @default.
• W4294243669 cites W2035749372 @default.
• W4294243669 cites W2042886692 @default.
• W4294243669 cites W2053848630 @default.
• W4294243669 cites W2054157485 @default.
• W4294243669 cites W2056455016 @default.
• W4294243669 cites W2072582207 @default.
• W4294243669 cites W2073711383 @default.
• W4294243669 cites W2073732562 @default.
• W4294243669 cites W2075425779 @default.
• W4294243669 cites W2075688250 @default.
• W4294243669 cites W2081950219 @default.
• W4294243669 cites W2082396456 @default.
• W4294243669 cites W2082600941 @default.
• W4294243669 cites W2084054732 @default.
• W4294243669 cites W2085778613 @default.
• W4294243669 cites W2092134177 @default.
• W4294243669 cites W2093898093 @default.
• W4294243669 cites W2113012685 @default.
• W4294243669 cites W2124347122 @default.
• W4294243669 cites W2132167841 @default.
• W4294243669 cites W2136789364 @default.
• W4294243669 cites W2144001840 @default.
• W4294243669 cites W2159341392 @default.
• W4294243669 cites W2187544091 @default.
• W4294243669 cites W2297360377 @default.
• W4294243669 cites W2321798163 @default.
• W4294243669 cites W2340306432 @default.
• W4294243669 cites W2746706198 @default.
• W4294243669 cites W2747770253 @default.
• W4294243669 cites W2759529239 @default.
• W4294243669 cites W2765174355 @default.
• W4294243669 cites W2789816271 @default.
• W4294243669 cites W2791630744 @default.
• W4294243669 cites W2806371650 @default.
• W4294243669 cites W2884177372 @default.
• W4294243669 cites W2891188011 @default.
• W4294243669 cites W2913608654 @default.
• W4294243669 cites W2995884607 @default.
• W4294243669 cites W2996579452 @default.
• W4294243669 cites W2999560304 @default.
• W4294243669 cites W3037795072 @default.
• W4294243669 cites W3049538137 @default.
• W4294243669 cites W3091266211 @default.
• W4294243669 cites W3123603246 @default.
• W4294243669 cites W3130092591 @default.
• W4294243669 cites W3138933334 @default.
• W4294243669 cites W3170966170 @default.
• W4294243669 cites W3193771356 @default.
• W4294243669 cites W3197290175 @default.
• W4294243669 cites W4226302578 @default.
• W4294243669 cites W4287532062 @default.
• W4294243669 doi "https://doi.org/10.3389/fbioe.2022.921486" @default.
• W4294243669 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36118571" @default.
• W4294243669 hasPublicationYear "2022" @default.
• W4294243669 type Work @default.
• W4294243669 citedByCount "1" @default.
• W4294243669 countsByYear W42942436692023 @default.
• W4294243669 crossrefType "journal-article" @default.
• W4294243669 hasAuthorship W4294243669A5004333984 @default.
• W4294243669 hasAuthorship W4294243669A5011513598 @default.
• W4294243669 hasAuthorship W4294243669A5016658297 @default.
• W4294243669 hasAuthorship W4294243669A5018898872 @default.
• W4294243669 hasAuthorship W4294243669A5027832717 @default.
• W4294243669 hasAuthorship W4294243669A5030068339 @default.
• W4294243669 hasAuthorship W4294243669A5031188468 @default.
• W4294243669 hasAuthorship W4294243669A5049634551 @default.
• W4294243669 hasAuthorship W4294243669A5058709659 @default.
• W4294243669 hasBestOaLocation W42942436691 @default.

• next