Matches in SemOpenAlex for { <https://semopenalex.org/work/W4294276875> ?p ?o ?g. }
- W4294276875 endingPage "53" @default.
- W4294276875 startingPage "41" @default.
- W4294276875 abstract "Exposure to silica is a cause of pulmonary fibrosis disease termed silicosis, which leads to respiratory failure and ultimately death. However, what drives fibrosis is not fully elucidated and therapeutic options remain limited. Our previous RNA-sequencing analysis showed that the expression of caveolin-1 (CAV1) was downregulated in silica-inhaled mouse lung tissues. Here, we not only verified that CAV1 was decreased in silica-induced fibrotic mouse lung tissues in both messenger RNA and protein levels, but also found that CSP7, a functional peptide of CAV1, could attenuate pulmonary fibrosis in vivo. Further in vitro experiments revealed that CAV1 reduced the expression of Yes-associated protein 1(YAP1) and affected its nuclear translocation in fibroblasts. In addition, Glutaminase 1 (GLS1), a key regulator of glutaminolysis, was identified to be a downstream effector of YAP1. CAV1 could suppress the activity of YAP1 to decrease the transcription of GLS1, thereby inhibiting fibroblast activation. Taken together, our results demonstrated that CAV1 and its functional peptide CSP7 may be potential molecules or drugs for the prevention and intervention of silicosis." @default.
- W4294276875 created "2022-09-02" @default.
- W4294276875 creator A5008659449 @default.
- W4294276875 creator A5017109691 @default.
- W4294276875 creator A5033632697 @default.
- W4294276875 creator A5054297168 @default.
- W4294276875 creator A5066188252 @default.
- W4294276875 creator A5067291135 @default.
- W4294276875 creator A5069991775 @default.
- W4294276875 creator A5071753253 @default.
- W4294276875 creator A5085752561 @default.
- W4294276875 date "2022-09-02" @default.
- W4294276875 modified "2023-10-18" @default.
- W4294276875 title "Caveolin-1 and Its Functional Peptide CSP7 Affect Silica-Induced Pulmonary Fibrosis by Regulating Fibroblast Glutaminolysis" @default.
- W4294276875 cites W1993803695 @default.
- W4294276875 cites W2011028349 @default.
- W4294276875 cites W2050886235 @default.
- W4294276875 cites W2139345025 @default.
- W4294276875 cites W2149360212 @default.
- W4294276875 cites W2301389244 @default.
- W4294276875 cites W2763979543 @default.
- W4294276875 cites W2771792762 @default.
- W4294276875 cites W2774778980 @default.
- W4294276875 cites W2795425364 @default.
- W4294276875 cites W2811098386 @default.
- W4294276875 cites W2886968113 @default.
- W4294276875 cites W2891330967 @default.
- W4294276875 cites W2891730522 @default.
- W4294276875 cites W2897375104 @default.
- W4294276875 cites W2901031536 @default.
- W4294276875 cites W2908013762 @default.
- W4294276875 cites W2928749667 @default.
- W4294276875 cites W2938184291 @default.
- W4294276875 cites W2970726552 @default.
- W4294276875 cites W2979711656 @default.
- W4294276875 cites W2980249524 @default.
- W4294276875 cites W2980626003 @default.
- W4294276875 cites W2994920268 @default.
- W4294276875 cites W2998590236 @default.
- W4294276875 cites W3015599110 @default.
- W4294276875 cites W3019227983 @default.
- W4294276875 cites W3022685083 @default.
- W4294276875 cites W3029224395 @default.
- W4294276875 cites W3033555274 @default.
- W4294276875 cites W3045145592 @default.
- W4294276875 cites W3047435091 @default.
- W4294276875 cites W3065741572 @default.
- W4294276875 cites W3080720981 @default.
- W4294276875 cites W3084662555 @default.
- W4294276875 cites W3107757751 @default.
- W4294276875 cites W3108791279 @default.
- W4294276875 cites W3116084499 @default.
- W4294276875 cites W3133765206 @default.
- W4294276875 cites W3136827855 @default.
- W4294276875 cites W3137229802 @default.
- W4294276875 cites W3139147934 @default.
- W4294276875 cites W3149128404 @default.
- W4294276875 cites W3155928989 @default.
- W4294276875 cites W3165551261 @default.
- W4294276875 cites W3168637581 @default.
- W4294276875 cites W3176701427 @default.
- W4294276875 cites W3177486724 @default.
- W4294276875 cites W3177636237 @default.
- W4294276875 cites W3191800267 @default.
- W4294276875 cites W4200467354 @default.
- W4294276875 cites W4221122792 @default.
- W4294276875 cites W4229716113 @default.
- W4294276875 cites W832922239 @default.
- W4294276875 doi "https://doi.org/10.1093/toxsci/kfac089" @default.
- W4294276875 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36053221" @default.
- W4294276875 hasPublicationYear "2022" @default.
- W4294276875 type Work @default.
- W4294276875 citedByCount "0" @default.
- W4294276875 crossrefType "journal-article" @default.
- W4294276875 hasAuthorship W4294276875A5008659449 @default.
- W4294276875 hasAuthorship W4294276875A5017109691 @default.
- W4294276875 hasAuthorship W4294276875A5033632697 @default.
- W4294276875 hasAuthorship W4294276875A5054297168 @default.
- W4294276875 hasAuthorship W4294276875A5066188252 @default.
- W4294276875 hasAuthorship W4294276875A5067291135 @default.
- W4294276875 hasAuthorship W4294276875A5069991775 @default.
- W4294276875 hasAuthorship W4294276875A5071753253 @default.
- W4294276875 hasAuthorship W4294276875A5085752561 @default.
- W4294276875 hasConcept C104317684 @default.
- W4294276875 hasConcept C121608353 @default.
- W4294276875 hasConcept C126322002 @default.
- W4294276875 hasConcept C142724271 @default.
- W4294276875 hasConcept C185592680 @default.
- W4294276875 hasConcept C2777714996 @default.
- W4294276875 hasConcept C2777811718 @default.
- W4294276875 hasConcept C2778160063 @default.
- W4294276875 hasConcept C2778341716 @default.
- W4294276875 hasConcept C2780219982 @default.
- W4294276875 hasConcept C2780559512 @default.
- W4294276875 hasConcept C2780870201 @default.
- W4294276875 hasConcept C2781244666 @default.
- W4294276875 hasConcept C502942594 @default.
- W4294276875 hasConcept C54355233 @default.