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- W4294295997 abstract "Staphylococcus and Streptococcus , two groups of major human pathogens, are equipped with a fatty acid kinase (Fak) machinery to scavenge host fatty acids. The Fak complex is contains an ATP-binding subunit FakA, which interacts with varied FakB isoforms, and synthesizes acyl-phosphate from extracellular fatty acids. However, how FakA recognizes its FakB partners and then activates different fatty acids is poorly understood. Here, we systematically describe the Fak system from the zoonotic pathogen, Streptococcus suis . The crystal structure of SsFakA complexed with SsFakB2 was determined at 2.6 Å resolution. An in vitro system of Fak-PlsX (phosphate: acyl-ACP transacylase) was developed to track acyl-phosphate intermediate and its final product acyl-ACP. Structure-guided mutagenesis enabled us to characterize a mechanism for streptococcal FakA working with FakB partners engaged in host fatty acid scavenging. These findings offer a comprehensive description of the Fak kinase machinery, thus advancing the discovery of attractive targets against deadly infections with Streptococcus ." @default.
- W4294295997 created "2022-09-02" @default.
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- W4294295997 date "2022-09-02" @default.
- W4294295997 modified "2023-09-30" @default.
- W4294295997 title "Structure and mechanism for streptococcal fatty acid kinase (Fak) system dedicated to host fatty acid scavenging" @default.
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- W4294295997 doi "https://doi.org/10.1126/sciadv.abq3944" @default.
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