FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4294335366> ?p ?o ?g. }

• W4294335366 endingPage "e2358" @default.
• W4294335366 startingPage "e2346" @default.
• W4294335366 abstract "Background and Objectives Recent studies have shown that global cognitive ability tends to decline faster over time in older adults (≥65 years) with epilepsy compared with older adults without epilepsy. Scarce data exist about the role of vascular risk factors (VRFs) on cognitive course in epilepsy. We assessed whether the associations of individual VRFs with cognitive trajectory differed depending on the presence of prevalent epilepsy. Methods The Cardiovascular Health Study is a population-based longitudinal cohort study of 5,888 US adults aged ≥65 years. Cognitive function was assessed annually with modified Mini-Mental State Examination (3MS; global cognitive ability) and Digit Symbol Substitution Test (DSST; information processing speed). We used linear mixed models to estimate the individual and joint associations of epilepsy and VRFs with cognitive decline by modeling epilepsy × VRF interactions one by one, each adjusted for all other VRFs considered, including demographics, health behaviors, clinical characteristics, and comorbid diagnoses. From these models, we estimated excess mean cognitive decline due to interaction of epilepsy with each VRF. Results We observed excess mean decline in global cognitive ability (3MS) due to interactions of epilepsy with hypertension (6.6 points greater mean 8-year decline than expected if no interaction; 95% CI 1.3–12.0) and with abstaining from alcohol (5.8 points greater than expected; 95% CI 0.3–11.3). We also observed excess mean decline in information processing speed (DSST) due to interactions of epilepsy with prior stroke (18.1 points greater mean 9-year decline than expected; 95% CI 7.6–28.5), with abstaining from alcohol (6.1 points greater than expected; 95% CI 2.5–9.8), and with higher triglyceride levels (2.4 points greater than expected per SD; 95% CI 0.4–4.3). Discussion Associations of some VRFs with cognitive decline in older adults are stronger in the presence of epilepsy, suggesting a need for greater attention to vascular protection for preserving brain health in older adults with epilepsy." @default.
• W4294335366 created "2022-09-02" @default.
• W4294335366 creator A5007306188 @default.
• W4294335366 creator A5021756508 @default.
• W4294335366 creator A5035161117 @default.
• W4294335366 creator A5040090833 @default.
• W4294335366 creator A5042258539 @default.
• W4294335366 creator A5056721281 @default.
• W4294335366 creator A5087762288 @default.
• W4294335366 date "2022-11-22" @default.
• W4294335366 modified "2023-10-01" @default.
• W4294335366 title "Epilepsy, Vascular Risk Factors, and Cognitive Decline in Older Adults" @default.
• W4294335366 cites W1562031459 @default.
• W4294335366 cites W1837550595 @default.
• W4294335366 cites W1965138593 @default.
• W4294335366 cites W1968204283 @default.
• W4294335366 cites W1968450664 @default.
• W4294335366 cites W1983985535 @default.
• W4294335366 cites W1985920977 @default.
• W4294335366 cites W1987482328 @default.
• W4294335366 cites W1991419466 @default.
• W4294335366 cites W1999664376 @default.
• W4294335366 cites W2006551824 @default.
• W4294335366 cites W2019334838 @default.
• W4294335366 cites W2029038720 @default.
• W4294335366 cites W2030108523 @default.
• W4294335366 cites W2033361083 @default.
• W4294335366 cites W2047487074 @default.
• W4294335366 cites W2082266356 @default.
• W4294335366 cites W2087625744 @default.
• W4294335366 cites W2090140552 @default.
• W4294335366 cites W2091163929 @default.
• W4294335366 cites W2097124992 @default.
• W4294335366 cites W2105541876 @default.
• W4294335366 cites W2115620754 @default.
• W4294335366 cites W2118931743 @default.
• W4294335366 cites W2129901270 @default.
• W4294335366 cites W2136239752 @default.
• W4294335366 cites W2140031808 @default.
• W4294335366 cites W2140286457 @default.
• W4294335366 cites W2148573574 @default.
• W4294335366 cites W2149840158 @default.
• W4294335366 cites W2150884892 @default.
• W4294335366 cites W2161197885 @default.
• W4294335366 cites W2162009057 @default.
• W4294335366 cites W2169322502 @default.
• W4294335366 cites W2323540614 @default.
• W4294335366 cites W2580008281 @default.
• W4294335366 cites W2736307756 @default.
• W4294335366 cites W2750784726 @default.
• W4294335366 cites W2775635068 @default.
• W4294335366 cites W2805887382 @default.
• W4294335366 cites W2914535606 @default.
• W4294335366 cites W2914871691 @default.
• W4294335366 cites W2966966909 @default.
• W4294335366 cites W3010483969 @default.
• W4294335366 cites W3032784914 @default.
• W4294335366 cites W3044720345 @default.
• W4294335366 cites W3107006831 @default.
• W4294335366 cites W3109815106 @default.
• W4294335366 doi "https://doi.org/10.1212/wnl.0000000000201187" @default.
• W4294335366 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36240101" @default.
• W4294335366 hasPublicationYear "2022" @default.
• W4294335366 type Work @default.
• W4294335366 citedByCount "2" @default.
• W4294335366 countsByYear W42943353662023 @default.
• W4294335366 crossrefType "journal-article" @default.
• W4294335366 hasAuthorship W4294335366A5007306188 @default.
• W4294335366 hasAuthorship W4294335366A5021756508 @default.
• W4294335366 hasAuthorship W4294335366A5035161117 @default.
• W4294335366 hasAuthorship W4294335366A5040090833 @default.
• W4294335366 hasAuthorship W4294335366A5042258539 @default.
• W4294335366 hasAuthorship W4294335366A5056721281 @default.
• W4294335366 hasAuthorship W4294335366A5087762288 @default.
• W4294335366 hasBestOaLocation W42943353662 @default.
• W4294335366 hasConcept C118552586 @default.
• W4294335366 hasConcept C126322002 @default.
• W4294335366 hasConcept C127413603 @default.
• W4294335366 hasConcept C142724271 @default.
• W4294335366 hasConcept C15744967 @default.
• W4294335366 hasConcept C169900460 @default.
• W4294335366 hasConcept C1862650 @default.
• W4294335366 hasConcept C204787440 @default.
• W4294335366 hasConcept C27081682 @default.
• W4294335366 hasConcept C2777965283 @default.
• W4294335366 hasConcept C2778186239 @default.
• W4294335366 hasConcept C2779134260 @default.
• W4294335366 hasConcept C2779483572 @default.
• W4294335366 hasConcept C2780645631 @default.
• W4294335366 hasConcept C2908647359 @default.
• W4294335366 hasConcept C2984863031 @default.
• W4294335366 hasConcept C6057870 @default.
• W4294335366 hasConcept C71924100 @default.
• W4294335366 hasConcept C72563966 @default.
• W4294335366 hasConcept C74909509 @default.
• W4294335366 hasConcept C78519656 @default.
• W4294335366 hasConcept C99454951 @default.
• W4294335366 hasConceptScore W4294335366C118552586 @default.

• next