Matches in SemOpenAlex for { <https://semopenalex.org/work/W4294364093> ?p ?o ?g. }
Showing items 1 to 100 of
100
with 100 items per page.
- W4294364093 endingPage "166" @default.
- W4294364093 startingPage "155" @default.
- W4294364093 abstract "Dynactin (DCTN) can activate cytoplasmic dynein and drive intracellular organelle transport containing six family members (DCTN1 to DCTN6). The DCTN family has been studied as cancer-related genes or biomarkers in various cancers. Nevertheless, in hepatocellular carcinoma (HCC), the functions and prognostic roles of the DCTN family have been unexplored. We evaluated the diagnostic and survival effects of DCTN subunits in HCC through bioinformatics analysis and validated the results of bioinformatics by our data to address this problem. The results of bioinformatics analysis found that DCTN2 was a significant prognostic factor in HCC, and high-level DCTN2 can predict poor patient survival in HCC. Cox regression analysis also suggested that DCTN2 (hazard ratio = 1.748, 95% confidence interval 1.190–2.568, P = 0.004) is an independent prognostic factor for patient survival. Western blot and quantitative reverse transcription-polymerase chain reaction assays confirmed that the protein and mRNA expression levels of DCTN2 were upregulated in HCC cell lines. The proliferation, invasion, and migration were decreased and cell apoptosis was enhanced after DCTN2 was knocked down in Huh7 and Hep3B cells. DCTN2 promoted the cell cycle progression through regulating the expression of cell cycle regulatory proteins cyclin-dependent kinase 4, Cyclin D1, and p21. We propose that DCTN2 can serve as a prognostic marker for HCC. DCTN2 acts as an oncogene and promotes the cell cycle progression through the G1/S phase-related signaling pathway." @default.
- W4294364093 created "2022-09-03" @default.
- W4294364093 creator A5020852276 @default.
- W4294364093 creator A5027090919 @default.
- W4294364093 creator A5039737834 @default.
- W4294364093 creator A5059296721 @default.
- W4294364093 creator A5059723070 @default.
- W4294364093 creator A5062768886 @default.
- W4294364093 creator A5065278413 @default.
- W4294364093 creator A5076988030 @default.
- W4294364093 creator A5090815103 @default.
- W4294364093 date "2022-09-01" @default.
- W4294364093 modified "2023-10-16" @default.
- W4294364093 title "Dynactin 2 acts as an oncogene in hepatocellular carcinoma through promoting cell cycle progression" @default.
- W4294364093 cites W1517941364 @default.
- W4294364093 cites W1565164066 @default.
- W4294364093 cites W1572461519 @default.
- W4294364093 cites W1686747255 @default.
- W4294364093 cites W1977918192 @default.
- W4294364093 cites W1984979116 @default.
- W4294364093 cites W2015058678 @default.
- W4294364093 cites W2058768471 @default.
- W4294364093 cites W2072770566 @default.
- W4294364093 cites W2076552007 @default.
- W4294364093 cites W2083034193 @default.
- W4294364093 cites W2085934079 @default.
- W4294364093 cites W2111979660 @default.
- W4294364093 cites W2126496132 @default.
- W4294364093 cites W2140911476 @default.
- W4294364093 cites W2143017330 @default.
- W4294364093 cites W2148937096 @default.
- W4294364093 cites W2151305493 @default.
- W4294364093 cites W2159686257 @default.
- W4294364093 cites W2165556828 @default.
- W4294364093 cites W2193673085 @default.
- W4294364093 cites W2229298963 @default.
- W4294364093 cites W2272596767 @default.
- W4294364093 cites W2463600666 @default.
- W4294364093 cites W2589420311 @default.
- W4294364093 cites W2614935042 @default.
- W4294364093 cites W2736730167 @default.
- W4294364093 cites W2752663558 @default.
- W4294364093 cites W2806609003 @default.
- W4294364093 cites W2895926103 @default.
- W4294364093 cites W2901096079 @default.
- W4294364093 cites W2953106150 @default.
- W4294364093 cites W2973026428 @default.
- W4294364093 cites W3128646645 @default.
- W4294364093 cites W4210793050 @default.
- W4294364093 cites W4211105405 @default.
- W4294364093 doi "https://doi.org/10.1016/j.livres.2022.07.002" @default.
- W4294364093 hasPublicationYear "2022" @default.
- W4294364093 type Work @default.
- W4294364093 citedByCount "2" @default.
- W4294364093 countsByYear W42943640932023 @default.
- W4294364093 crossrefType "journal-article" @default.
- W4294364093 hasAuthorship W4294364093A5020852276 @default.
- W4294364093 hasAuthorship W4294364093A5027090919 @default.
- W4294364093 hasAuthorship W4294364093A5039737834 @default.
- W4294364093 hasAuthorship W4294364093A5059296721 @default.
- W4294364093 hasAuthorship W4294364093A5059723070 @default.
- W4294364093 hasAuthorship W4294364093A5062768886 @default.
- W4294364093 hasAuthorship W4294364093A5065278413 @default.
- W4294364093 hasAuthorship W4294364093A5076988030 @default.
- W4294364093 hasAuthorship W4294364093A5090815103 @default.
- W4294364093 hasBestOaLocation W42943640931 @default.
- W4294364093 hasConcept C1491633281 @default.
- W4294364093 hasConcept C199835354 @default.
- W4294364093 hasConcept C2781018059 @default.
- W4294364093 hasConcept C29537977 @default.
- W4294364093 hasConcept C502942594 @default.
- W4294364093 hasConcept C54355233 @default.
- W4294364093 hasConcept C86803240 @default.
- W4294364093 hasConceptScore W4294364093C1491633281 @default.
- W4294364093 hasConceptScore W4294364093C199835354 @default.
- W4294364093 hasConceptScore W4294364093C2781018059 @default.
- W4294364093 hasConceptScore W4294364093C29537977 @default.
- W4294364093 hasConceptScore W4294364093C502942594 @default.
- W4294364093 hasConceptScore W4294364093C54355233 @default.
- W4294364093 hasConceptScore W4294364093C86803240 @default.
- W4294364093 hasIssue "3" @default.
- W4294364093 hasLocation W42943640931 @default.
- W4294364093 hasOpenAccess W4294364093 @default.
- W4294364093 hasPrimaryLocation W42943640931 @default.
- W4294364093 hasRelatedWork W1948889165 @default.
- W4294364093 hasRelatedWork W2013115645 @default.
- W4294364093 hasRelatedWork W2161139902 @default.
- W4294364093 hasRelatedWork W2511084206 @default.
- W4294364093 hasRelatedWork W2530512275 @default.
- W4294364093 hasRelatedWork W2777311301 @default.
- W4294364093 hasRelatedWork W2884184577 @default.
- W4294364093 hasRelatedWork W2896912519 @default.
- W4294364093 hasRelatedWork W2955113018 @default.
- W4294364093 hasRelatedWork W3209843007 @default.
- W4294364093 hasVolume "6" @default.
- W4294364093 isParatext "false" @default.
- W4294364093 isRetracted "false" @default.
- W4294364093 workType "article" @default.