FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4294384562> ?p ?o ?g. }

• W4294384562 abstract "Abstract Previous studies showed that pro-inflammatory chemokines CX3CL1 and CXCL12 bound to the allosteric binding site (site 2) of integrins and allosterically activated integrins, in addition to the classical ligand-binding site (site 1). We showed that CCL5 also bound to site 2, in addition to site 1, and activated soluble integrin αvβ3. Platelet integrin αIIbβ3, a fibrinogen receptor, is critical for hemostasis and thrombus formation and activation of αIIbβ3 is a key event for thrombus formation. Activation of αIIbβ3 is known to be mediated exclusively by inside-out signaling. We studied if αIIbβ3 can be allosterically activated. We discovered that CCL5, CXCL12, and CX3CL1 are new ligands for αIIbβ3. Notably they enhanced the binding of monovalent ligand to soluble αIIbβ3 in 1 mM Ca 2+ by binding to site 2. They activated cell-surface αIIbβ3 on CHO cells quickly (half maximal response <1 min) and at low concentrations (1-10 ng/ml) compared to soluble αIIbβ3, probably because chemokines bind to cell surface proteoglycans. Notably, activation of αIIbβ3 by the chemokines was several times more potent than 1 mM Mn 2+ . Since CCL5 and CXCL12 are stored in platelet granules and rapidly transported to the surface upon platelet activation, we hypothesized that they are released from the granules and allosterically activate αIIbβ3 by binding to site 2. Transmembrane CX3CL1 on activated endothelial cells likely mediates platelet-endothelial interaction by binding to and activating αIIbβ3. Also, over-produced chemokines during inflammation may trigger αIIbβ3 activation, which is a possible missing link between inflammation and thrombosis." @default.
• W4294384562 created "2022-09-03" @default.
• W4294384562 creator A5040149575 @default.
• W4294384562 creator A5063789922 @default.
• W4294384562 date "2022-09-02" @default.
• W4294384562 modified "2023-09-28" @default.
• W4294384562 title "Pro-inflammatory chemokines CCL5, CXCL12, and CX3CL1 bind to and activate platelet integrin αIIbβ3 in an allosteric manner" @default.
• W4294384562 cites W1482962573 @default.
• W4294384562 cites W1494810979 @default.
• W4294384562 cites W1519162499 @default.
• W4294384562 cites W1560566673 @default.
• W4294384562 cites W1564633285 @default.
• W4294384562 cites W1576773659 @default.
• W4294384562 cites W1604526865 @default.
• W4294384562 cites W1663019954 @default.
• W4294384562 cites W1804074798 @default.
• W4294384562 cites W1863469710 @default.
• W4294384562 cites W1963984954 @default.
• W4294384562 cites W1969802279 @default.
• W4294384562 cites W1973943625 @default.
• W4294384562 cites W1974342547 @default.
• W4294384562 cites W1981149366 @default.
• W4294384562 cites W1984115097 @default.
• W4294384562 cites W1995553619 @default.
• W4294384562 cites W1998310721 @default.
• W4294384562 cites W1999684167 @default.
• W4294384562 cites W2004657919 @default.
• W4294384562 cites W2008669330 @default.
• W4294384562 cites W2012691080 @default.
• W4294384562 cites W2016916867 @default.
• W4294384562 cites W2020114629 @default.
• W4294384562 cites W2021165859 @default.
• W4294384562 cites W2029196614 @default.
• W4294384562 cites W2046356130 @default.
• W4294384562 cites W2050717189 @default.
• W4294384562 cites W2053603627 @default.
• W4294384562 cites W2059084316 @default.
• W4294384562 cites W2064873657 @default.
• W4294384562 cites W2066682264 @default.
• W4294384562 cites W2071660679 @default.
• W4294384562 cites W2082539776 @default.
• W4294384562 cites W2085299722 @default.
• W4294384562 cites W2090659127 @default.
• W4294384562 cites W2096330567 @default.
• W4294384562 cites W2109425462 @default.
• W4294384562 cites W2124618760 @default.
• W4294384562 cites W2126972955 @default.
• W4294384562 cites W2127909173 @default.
• W4294384562 cites W2128042751 @default.
• W4294384562 cites W2134782115 @default.
• W4294384562 cites W2136384184 @default.
• W4294384562 cites W2145738273 @default.
• W4294384562 cites W2147303583 @default.
• W4294384562 cites W2154229564 @default.
• W4294384562 cites W2167861740 @default.
• W4294384562 cites W2171248814 @default.
• W4294384562 cites W2171581347 @default.
• W4294384562 cites W2774990976 @default.
• W4294384562 cites W2781479864 @default.
• W4294384562 cites W3174920566 @default.
• W4294384562 cites W3198637955 @default.
• W4294384562 cites W4230407225 @default.
• W4294384562 cites W4251025034 @default.
• W4294384562 cites W49012675 @default.
• W4294384562 doi "https://doi.org/10.1101/2022.09.01.506262" @default.
• W4294384562 hasPublicationYear "2022" @default.
• W4294384562 type Work @default.
• W4294384562 citedByCount "1" @default.
• W4294384562 countsByYear W42943845622023 @default.
• W4294384562 crossrefType "posted-content" @default.
• W4294384562 hasAuthorship W4294384562A5040149575 @default.
• W4294384562 hasAuthorship W4294384562A5063789922 @default.
• W4294384562 hasBestOaLocation W42943845621 @default.
• W4294384562 hasConcept C107824862 @default.
• W4294384562 hasConcept C13373296 @default.
• W4294384562 hasConcept C166342909 @default.
• W4294384562 hasConcept C170493617 @default.
• W4294384562 hasConcept C185592680 @default.
• W4294384562 hasConcept C195687474 @default.
• W4294384562 hasConcept C203014093 @default.
• W4294384562 hasConcept C2910542480 @default.
• W4294384562 hasConcept C3018697912 @default.
• W4294384562 hasConcept C55493867 @default.
• W4294384562 hasConcept C86803240 @default.
• W4294384562 hasConcept C89560881 @default.
• W4294384562 hasConcept C95444343 @default.
• W4294384562 hasConceptScore W4294384562C107824862 @default.
• W4294384562 hasConceptScore W4294384562C13373296 @default.
• W4294384562 hasConceptScore W4294384562C166342909 @default.
• W4294384562 hasConceptScore W4294384562C170493617 @default.
• W4294384562 hasConceptScore W4294384562C185592680 @default.
• W4294384562 hasConceptScore W4294384562C195687474 @default.
• W4294384562 hasConceptScore W4294384562C203014093 @default.
• W4294384562 hasConceptScore W4294384562C2910542480 @default.
• W4294384562 hasConceptScore W4294384562C3018697912 @default.
• W4294384562 hasConceptScore W4294384562C55493867 @default.
• W4294384562 hasConceptScore W4294384562C86803240 @default.
• W4294384562 hasConceptScore W4294384562C89560881 @default.
• W4294384562 hasConceptScore W4294384562C95444343 @default.
• W4294384562 hasLocation W42943845621 @default.

• next