Matches in SemOpenAlex for { <https://semopenalex.org/work/W4294387621> ?p ?o ?g. }
- W4294387621 endingPage "94" @default.
- W4294387621 startingPage "94" @default.
- W4294387621 abstract "<ns4:p>The formation and viscoelastic properties of condensates of intrinsically disordered proteins (IDPs) is dictated by amino acid sequence and solution conditions. Because of the involvement of biomolecular condensates in cell physiology and disease, advancing our understanding of the relationship between protein sequence and phase separation (PS) may have important implications in the formulation of new therapeutic hypotheses. Here, we present CALVADOS 2, a coarse-grained model of IDPs that accurately predicts conformational properties and propensities to undergo PS for diverse sequences and solution conditions. In particular, we systematically study the effect of varying the range of the nonionic interactions and use our findings to improve the temperature scale of the model. We further optimize the residue-specific model parameters against experimental data on the conformational properties of 55 proteins, while also leveraging 70 hydrophobicity scales from the literature to avoid overfitting the training data. Extensive testing shows that the model accurately predicts chain compaction and PS propensity for sequences of diverse length and charge patterning, as well as at different temperatures and salt concentrations.</ns4:p>" @default.
- W4294387621 created "2022-09-03" @default.
- W4294387621 creator A5019872729 @default.
- W4294387621 creator A5068721769 @default.
- W4294387621 date "2022-08-05" @default.
- W4294387621 modified "2023-10-14" @default.
- W4294387621 title "Improved predictions of phase behaviour of intrinsically disordered proteins by tuning the interaction range" @default.
- W4294387621 cites W1903442907 @default.
- W4294387621 cites W1952608303 @default.
- W4294387621 cites W1976638865 @default.
- W4294387621 cites W2017983619 @default.
- W4294387621 cites W2018783142 @default.
- W4294387621 cites W2029223082 @default.
- W4294387621 cites W2031964168 @default.
- W4294387621 cites W2052660967 @default.
- W4294387621 cites W2092837180 @default.
- W4294387621 cites W2155276776 @default.
- W4294387621 cites W2155685362 @default.
- W4294387621 cites W2168958678 @default.
- W4294387621 cites W2328886310 @default.
- W4294387621 cites W2345490732 @default.
- W4294387621 cites W2463717668 @default.
- W4294387621 cites W2547162692 @default.
- W4294387621 cites W2612542354 @default.
- W4294387621 cites W2742396220 @default.
- W4294387621 cites W2749742076 @default.
- W4294387621 cites W2755105920 @default.
- W4294387621 cites W2761503010 @default.
- W4294387621 cites W2766770111 @default.
- W4294387621 cites W2783363964 @default.
- W4294387621 cites W2784384705 @default.
- W4294387621 cites W2788827529 @default.
- W4294387621 cites W2801412154 @default.
- W4294387621 cites W2810866092 @default.
- W4294387621 cites W2921383891 @default.
- W4294387621 cites W2949223833 @default.
- W4294387621 cites W2949701230 @default.
- W4294387621 cites W2953933961 @default.
- W4294387621 cites W2969788883 @default.
- W4294387621 cites W2975170167 @default.
- W4294387621 cites W2982006073 @default.
- W4294387621 cites W2982135975 @default.
- W4294387621 cites W2985557135 @default.
- W4294387621 cites W3005177895 @default.
- W4294387621 cites W3017082821 @default.
- W4294387621 cites W3022557047 @default.
- W4294387621 cites W3025909849 @default.
- W4294387621 cites W3033847448 @default.
- W4294387621 cites W3034018673 @default.
- W4294387621 cites W3080233562 @default.
- W4294387621 cites W3080337324 @default.
- W4294387621 cites W3083454345 @default.
- W4294387621 cites W3102696908 @default.
- W4294387621 cites W3113629859 @default.
- W4294387621 cites W3113647834 @default.
- W4294387621 cites W3118073689 @default.
- W4294387621 cites W3120901452 @default.
- W4294387621 cites W3126550244 @default.
- W4294387621 cites W3126870155 @default.
- W4294387621 cites W3131648453 @default.
- W4294387621 cites W3144362239 @default.
- W4294387621 cites W3156859670 @default.
- W4294387621 cites W3157366826 @default.
- W4294387621 cites W3157400614 @default.
- W4294387621 cites W3157810520 @default.
- W4294387621 cites W3171889804 @default.
- W4294387621 cites W3173394729 @default.
- W4294387621 cites W3176932752 @default.
- W4294387621 cites W3186028397 @default.
- W4294387621 cites W3191096373 @default.
- W4294387621 cites W3191624148 @default.
- W4294387621 cites W3201816247 @default.
- W4294387621 cites W3208161977 @default.
- W4294387621 cites W3209712990 @default.
- W4294387621 cites W3210302262 @default.
- W4294387621 cites W3210449208 @default.
- W4294387621 cites W3211673143 @default.
- W4294387621 cites W3212759171 @default.
- W4294387621 cites W3215858345 @default.
- W4294387621 cites W4200346882 @default.
- W4294387621 cites W4213205382 @default.
- W4294387621 cites W4281390332 @default.
- W4294387621 cites W4281688348 @default.
- W4294387621 cites W4282821510 @default.
- W4294387621 cites W4283014865 @default.
- W4294387621 cites W4284976364 @default.
- W4294387621 doi "https://doi.org/10.12688/openreseurope.14967.1" @default.
- W4294387621 hasPublicationYear "2022" @default.
- W4294387621 type Work @default.
- W4294387621 citedByCount "6" @default.
- W4294387621 countsByYear W42943876212022 @default.
- W4294387621 countsByYear W42943876212023 @default.
- W4294387621 crossrefType "journal-article" @default.
- W4294387621 hasAuthorship W4294387621A5019872729 @default.
- W4294387621 hasAuthorship W4294387621A5068721769 @default.
- W4294387621 hasBestOaLocation W42943876211 @default.
- W4294387621 hasConcept C12554922 @default.
- W4294387621 hasConcept C154945302 @default.