Matches in SemOpenAlex for { <https://semopenalex.org/work/W4294439994> ?p ?o ?g. }
- W4294439994 endingPage "1947" @default.
- W4294439994 startingPage "1931" @default.
- W4294439994 abstract "Alzheimer’s disease (AD) is a neurodegenerative age-related brain disease which diminishes learning and memory. Two main cholinesterases (ChEs), first acetylcholinesterase (AChE) and second one butyrylcholinesterase (BChE) are the major targets to treat this disease. In the current study, six novel pyrazolo-benzothiazole analogues were systematically planned, synthesized, and biological tested for their ChEs activities, antioxidant, enzyme kinetic, self-induced Aβ modulation, PAMPA-BBB, and docking and molecular simulation study. Among all derivatives, compound 4a bearing 3,4-dimethoxypyrazolo-benzothiazole was the potential inhibitor of AChE (IC50 = 8.69 ± 0.42 µM), Aβ modulator and good antioxidant property. Docking studies also clearly revealed that compound 4a fit fully into the active sites of hAChE." @default.
- W4294439994 created "2022-09-03" @default.
- W4294439994 creator A5004150122 @default.
- W4294439994 creator A5004420571 @default.
- W4294439994 creator A5016806799 @default.
- W4294439994 creator A5087278268 @default.
- W4294439994 date "2022-09-03" @default.
- W4294439994 modified "2023-09-27" @default.
- W4294439994 title "Design, Synthesis, and biological evaluation of pyrazolo-benzothiazole derivatives as a potential therapeutic agent for the treatment of Alzheimer’s disease" @default.
- W4294439994 cites W1215562505 @default.
- W4294439994 cites W1987327282 @default.
- W4294439994 cites W1991794210 @default.
- W4294439994 cites W1994264985 @default.
- W4294439994 cites W1999494613 @default.
- W4294439994 cites W2017196167 @default.
- W4294439994 cites W2021832765 @default.
- W4294439994 cites W2026976753 @default.
- W4294439994 cites W2032817710 @default.
- W4294439994 cites W2036537800 @default.
- W4294439994 cites W2060079863 @default.
- W4294439994 cites W2073417483 @default.
- W4294439994 cites W2076598575 @default.
- W4294439994 cites W2095719702 @default.
- W4294439994 cites W2102377211 @default.
- W4294439994 cites W2112006614 @default.
- W4294439994 cites W2130479394 @default.
- W4294439994 cites W2153228625 @default.
- W4294439994 cites W2329455500 @default.
- W4294439994 cites W2346785712 @default.
- W4294439994 cites W2414131286 @default.
- W4294439994 cites W2417883866 @default.
- W4294439994 cites W2568450381 @default.
- W4294439994 cites W2793164549 @default.
- W4294439994 cites W2895004036 @default.
- W4294439994 cites W2911657223 @default.
- W4294439994 cites W2944155053 @default.
- W4294439994 cites W2960123188 @default.
- W4294439994 cites W2963055131 @default.
- W4294439994 cites W2965717703 @default.
- W4294439994 cites W2995524402 @default.
- W4294439994 cites W2999319101 @default.
- W4294439994 cites W3015770227 @default.
- W4294439994 cites W3099128996 @default.
- W4294439994 cites W3121516100 @default.
- W4294439994 cites W3129333271 @default.
- W4294439994 cites W3129723783 @default.
- W4294439994 cites W3129992505 @default.
- W4294439994 cites W3182694033 @default.
- W4294439994 cites W3197748178 @default.
- W4294439994 cites W3198352952 @default.
- W4294439994 cites W4200426683 @default.
- W4294439994 doi "https://doi.org/10.1007/s00044-022-02953-4" @default.
- W4294439994 hasPublicationYear "2022" @default.
- W4294439994 type Work @default.
- W4294439994 citedByCount "0" @default.
- W4294439994 crossrefType "journal-article" @default.
- W4294439994 hasAuthorship W4294439994A5004150122 @default.
- W4294439994 hasAuthorship W4294439994A5004420571 @default.
- W4294439994 hasAuthorship W4294439994A5016806799 @default.
- W4294439994 hasAuthorship W4294439994A5087278268 @default.
- W4294439994 hasBestOaLocation W42944399942 @default.
- W4294439994 hasConcept C126322002 @default.
- W4294439994 hasConcept C159110408 @default.
- W4294439994 hasConcept C181199279 @default.
- W4294439994 hasConcept C185592680 @default.
- W4294439994 hasConcept C202751555 @default.
- W4294439994 hasConcept C21951064 @default.
- W4294439994 hasConcept C2777456753 @default.
- W4294439994 hasConcept C2777752497 @default.
- W4294439994 hasConcept C2778004101 @default.
- W4294439994 hasConcept C2778816929 @default.
- W4294439994 hasConcept C2779046751 @default.
- W4294439994 hasConcept C2779059548 @default.
- W4294439994 hasConcept C2779101902 @default.
- W4294439994 hasConcept C2779134260 @default.
- W4294439994 hasConcept C31896038 @default.
- W4294439994 hasConcept C41685203 @default.
- W4294439994 hasConcept C55493867 @default.
- W4294439994 hasConcept C71924100 @default.
- W4294439994 hasConcept C98274493 @default.
- W4294439994 hasConceptScore W4294439994C126322002 @default.
- W4294439994 hasConceptScore W4294439994C159110408 @default.
- W4294439994 hasConceptScore W4294439994C181199279 @default.
- W4294439994 hasConceptScore W4294439994C185592680 @default.
- W4294439994 hasConceptScore W4294439994C202751555 @default.
- W4294439994 hasConceptScore W4294439994C21951064 @default.
- W4294439994 hasConceptScore W4294439994C2777456753 @default.
- W4294439994 hasConceptScore W4294439994C2777752497 @default.
- W4294439994 hasConceptScore W4294439994C2778004101 @default.
- W4294439994 hasConceptScore W4294439994C2778816929 @default.
- W4294439994 hasConceptScore W4294439994C2779046751 @default.
- W4294439994 hasConceptScore W4294439994C2779059548 @default.
- W4294439994 hasConceptScore W4294439994C2779101902 @default.
- W4294439994 hasConceptScore W4294439994C2779134260 @default.
- W4294439994 hasConceptScore W4294439994C31896038 @default.
- W4294439994 hasConceptScore W4294439994C41685203 @default.
- W4294439994 hasConceptScore W4294439994C55493867 @default.
- W4294439994 hasConceptScore W4294439994C71924100 @default.