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• W4294489054 abstract "<h3>Background</h3> Fecal microbiota transplantation (FMT) has been used as a core therapy for treating dysbiosis-related diseases by remodeling gut microbiota. The methodology and technology for improving FMT are stepping forward. In order to improve the understanding on the clinical applications of FMT, we performed a systematic literature review on FMT published from 2011 to 2021. Here, we provided an overview of the reported clinical benefits from FMT, the methodology of processing FMT and the strategy of using FMT, and the regulations on FMT in global. <h3>Methods</h3> Our search terms were applied to medical publications and databases from EMBASE, MEDLINE, CNKI, and Wanfang Data from 1 January 2011 to 31 December 2021. The inclusion criteria included: (i) Studies referencing FMT for human subjects showing benefits; (ii) Article type: original full-text article, meeting abstracts and letters to the editor on the clinical studies; (iii) Reports in English or Chinese. Exclusion criteria include: (i) Duplicated reports; (ii) Non-original reports such as commentary, consensus, reviews, and meta-analysis; (iii) Publications in Chinese reporting on the same patients in an English article. <h3>Results</h3> A total of 14539 records were identified in the search. After the exclusion, removal of duplication and reviewing of full-text articles, we selected 782 searched studies for analysis in this review (IDDF2022-ABS-0211 Figure 1). We divided all studies into eight main categories: infections, gut diseases, microbiota-gut-liver axis, microbiota-gut-brain axis, metabolic diseases, oncology, hematological diseases, and other diseases. Each category was further subdivided into specific diseases. A total of 85 diseases are shown in IDDF2022-ABS-0211 Figure 2. The global trend in the benefits from FMT is shown in IDDF2022-ABS-0211 Figure 3. The methodology and the regulations on FMT in global are shown in IDDF2022-ABS-0211 Figure 4. <h3>Conclusions</h3> Since FMT was formally named in 2011, a total of emerging 85 diseases treated by FMT have been reported. The number of studies on FMT/WMT has increased dramatically within the past decade. Although many further controlled trials will be needed, the dramatic increase in reports has shown the promising future of FMT for dysbiosis-related diseases in the gut or beyond the gut." @default.
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• W4294489054 date "2022-09-01" @default.
• W4294489054 modified "2023-09-26" @default.
• W4294489054 title "IDDF2022-ABS-0211 Encyclopedia of fecal microbiota transplantation: a review of effectiveness in the treatment of 85 diseases" @default.
• W4294489054 doi "https://doi.org/10.1136/gutjnl-2022-iddf.225" @default.
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