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- W4294552006 abstract "SUMMARY Anosmia was identified as a hallmark of COVID-19 early in the pandemic, however, with the emergence of variants of concern, the clinical profile induced by SARS-CoV-2 infection has changed, with anosmia being less frequent. Here, we assessed the clinical, olfactory and neuroinflammatory conditions of golden hamsters infected with the original Wuhan SARS-CoV-2 strain, its isogenic ORF7-deletion mutant and three variants: Gamma, Delta, and Omicron/BA.1. We show that infected animals developed a variant-dependent clinical disease including anosmia, and that the ORF7 of SARS-CoV-2 contributes to the induction of olfactory dysfunction. Conversely, all SARS- CoV-2 variants were found to be neuroinvasive, regardless of the clinical presentation they induce. Taken together, this confirms that neuroinvasion and anosmia are independent phenomena upon SARS-CoV-2 infection. Using newly generated nanoluciferase-expressing SARS-CoV-2, we validated the olfactory pathway as a major entry point into the brain in vivo and demonstrated in vitro that SARS-CoV-2 travels retrogradely and anterogradely along axons in microfluidic neuron-epithelial networks. Graphical abstract" @default.
- W4294552006 created "2022-09-04" @default.
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- W4294552006 date "2022-08-31" @default.
- W4294552006 modified "2023-10-16" @default.
- W4294552006 title "Neuroinvasion and anosmia are independent phenomena upon infection with SARS-CoV-2 and its variants" @default.
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- W4294552006 doi "https://doi.org/10.1101/2022.08.31.505985" @default.
- W4294552006 hasPublicationYear "2022" @default.