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- W4294572725 abstract "An experimental method is described for the production of acute and chronic aortic valvular stenosis in dogs. The resulting lesion is similar physiologically and pathologically to that seen in human subjects with aortic valvular stenosis. Fusion of two commissures of the aortic valve by stainless steel clips led to gradual (about 3 weeks) development of mild-to-moderate aortic valvular stenosis. This degree of valvular obstruction was maintained for up to 24 weeks postoperatively. Valve leaflets were fibrotic and thickened, and the commissures were fused. Left ventricular hypertrophy was documented by the finding of increased left ventricular weights (average increase 44 per cent) and increased transverse diameters of the muscle cells. Fusion of all three aortic valve commissures by clips produced severe aortic stenosis immediately. In some animals, however, the valvular obstruction diminished progressively over the first 4 postoperative weeks; the leaflets tore, with resultant increase in valve area and development of aortic regurgitation. Possible applications of these models for hemodynamic and morphologic studies are discussed." @default.
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- W4294572725 date "1974-03-01" @default.
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- W4294572725 title "Experimental production of aortic valvular stenosis" @default.
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- W4294572725 doi "https://doi.org/10.1016/s0022-5223(19)40509-6" @default.
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