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- W4294573090 abstract "We have isolated and characterized the zebrafish ortholog of c-ret, a gene essential for renal organogenesis and enteric nervous system development in mammals. During zebrafish embryogenesis c-ret transcripts are expressed in a number of tissues including spinal motoneurons, pronephric ducts, cranial ganglia, pharyngeal arches, and the enteric nervous system. We have examined in detail the expression of c-ret during the development of identified spinal primary motoneurons. c-ret expression is regulated in a cell type-specific manner among the three primary motoneurons. c-ret is expressed at its highest levels in caudal primary (CaP) motoneurons and transcripts can be detected shortly before the expression of the CaP-specific gene, islet2. We suggest that c-ret may play a role in specifying CaP cell identity. c-ret is expressed at low levels in the other primary motoneurons and also in a subset of secondary motoneurons, suggesting that it may also play a broader role in motoneuronal survival or maintenance. © 1997 John Wiley & Sons, Inc. J Neurobiol 33: 749–768, 1997" @default.
- W4294573090 created "2022-09-05" @default.
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- W4294573090 date "1997-11-20" @default.
- W4294573090 modified "2023-10-18" @default.
- W4294573090 title "Expression ofc-ret in the zebrafish embryo: Potential roles in motoneuronal development" @default.
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- W4294573090 doi "https://doi.org/10.1002/(sici)1097-4695(19971120)33:6<749::aid-neu4>3.0.co;2-9" @default.
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