Matches in SemOpenAlex for { <https://semopenalex.org/work/W4294598982> ?p ?o ?g. }
- W4294598982 abstract "Human space travel and exploration are of interest to both the industrial and scientific community. However, there are many adverse effects of spaceflight on human physiology. In particular, there is a lack of understanding of the extent to which microgravity affects the immune system. T cells, key players of the adaptive immune system and long-term immunity, are present not only in blood circulation but also reside within the tissue. As of yet, studies investigating the effects of microgravity on T cells are limited to peripheral blood or traditional 2D cell culture that recapitulates circulating blood. To better mimic interstitial tissue, 3D cell culture has been well established for physiologically and pathologically relevant models. In this work, we utilize 2D cell culture and 3D collagen matrices to gain an understanding of how simulated microgravity, using a random positioning machine, affects both circulating and tissue-resident T cells. T cells were studied in both resting and activated stages. We found that 3D cell culture attenuates the effects of simulated microgravity on the T cells transcriptome and nuclear irregularities compared to 2D cell culture. Interestingly, simulated microgravity appears to have less effect on activated T cells compared to those in the resting stage. Overall, our work provides novel insights into the effects of simulated microgravity on circulating and tissue-resident T cells which could provide benefits for the health of space travellers." @default.
- W4294598982 created "2022-09-05" @default.
- W4294598982 creator A5017466301 @default.
- W4294598982 creator A5036724917 @default.
- W4294598982 creator A5040862288 @default.
- W4294598982 creator A5043286130 @default.
- W4294598982 creator A5050138790 @default.
- W4294598982 creator A5078752743 @default.
- W4294598982 date "2022-09-01" @default.
- W4294598982 modified "2023-10-06" @default.
- W4294598982 title "3D microenvironment attenuates simulated microgravity-mediated changes in T cell transcriptome" @default.
- W4294598982 cites W1968154874 @default.
- W4294598982 cites W1968870521 @default.
- W4294598982 cites W1969203090 @default.
- W4294598982 cites W1969982905 @default.
- W4294598982 cites W2000341255 @default.
- W4294598982 cites W2005425674 @default.
- W4294598982 cites W2009253992 @default.
- W4294598982 cites W2014660126 @default.
- W4294598982 cites W2015310734 @default.
- W4294598982 cites W2017712207 @default.
- W4294598982 cites W2019108476 @default.
- W4294598982 cites W2019706657 @default.
- W4294598982 cites W2021881561 @default.
- W4294598982 cites W2023564624 @default.
- W4294598982 cites W2054963254 @default.
- W4294598982 cites W2068099179 @default.
- W4294598982 cites W2068716056 @default.
- W4294598982 cites W2079048005 @default.
- W4294598982 cites W2086310075 @default.
- W4294598982 cites W2086708236 @default.
- W4294598982 cites W2090489196 @default.
- W4294598982 cites W2099092516 @default.
- W4294598982 cites W2102278945 @default.
- W4294598982 cites W2102490919 @default.
- W4294598982 cites W2108234281 @default.
- W4294598982 cites W2119088658 @default.
- W4294598982 cites W2120076861 @default.
- W4294598982 cites W2127675271 @default.
- W4294598982 cites W2131271579 @default.
- W4294598982 cites W2132725786 @default.
- W4294598982 cites W2134526812 @default.
- W4294598982 cites W2153191075 @default.
- W4294598982 cites W2159102156 @default.
- W4294598982 cites W2160191258 @default.
- W4294598982 cites W2162143298 @default.
- W4294598982 cites W2170912100 @default.
- W4294598982 cites W2179438025 @default.
- W4294598982 cites W2230606086 @default.
- W4294598982 cites W2335309161 @default.
- W4294598982 cites W2510875395 @default.
- W4294598982 cites W2513448306 @default.
- W4294598982 cites W2570082846 @default.
- W4294598982 cites W2574394173 @default.
- W4294598982 cites W2580597002 @default.
- W4294598982 cites W2589176351 @default.
- W4294598982 cites W2606668426 @default.
- W4294598982 cites W2610653692 @default.
- W4294598982 cites W2610932550 @default.
- W4294598982 cites W2618667882 @default.
- W4294598982 cites W2728164929 @default.
- W4294598982 cites W2749779298 @default.
- W4294598982 cites W2788672255 @default.
- W4294598982 cites W2805113998 @default.
- W4294598982 cites W2806404703 @default.
- W4294598982 cites W2807814711 @default.
- W4294598982 cites W2810114673 @default.
- W4294598982 cites W2886206256 @default.
- W4294598982 cites W2902453263 @default.
- W4294598982 cites W2902870864 @default.
- W4294598982 cites W2903808414 @default.
- W4294598982 cites W2905944509 @default.
- W4294598982 cites W2907787425 @default.
- W4294598982 cites W2921842588 @default.
- W4294598982 cites W2940223973 @default.
- W4294598982 cites W2951912016 @default.
- W4294598982 cites W2959814266 @default.
- W4294598982 cites W2972990570 @default.
- W4294598982 cites W3008258085 @default.
- W4294598982 cites W3022626511 @default.
- W4294598982 cites W3026896629 @default.
- W4294598982 cites W3031799184 @default.
- W4294598982 cites W3114753755 @default.
- W4294598982 cites W3138872986 @default.
- W4294598982 cites W3142571867 @default.
- W4294598982 cites W3162304792 @default.
- W4294598982 cites W3164330320 @default.
- W4294598982 cites W3168196490 @default.
- W4294598982 cites W3184687087 @default.
- W4294598982 cites W3190463157 @default.
- W4294598982 cites W3193604787 @default.
- W4294598982 cites W3197509114 @default.
- W4294598982 cites W3201096085 @default.
- W4294598982 cites W3201862854 @default.
- W4294598982 cites W3202207977 @default.
- W4294598982 cites W3211122020 @default.
- W4294598982 cites W3216086757 @default.
- W4294598982 cites W4206021934 @default.
- W4294598982 cites W4220844188 @default.
- W4294598982 cites W4226011872 @default.