FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4294607209> ?p ?o ?g. }

• W4294607209 abstract "It is well established that prenatal valproic acid exposure in rats leads to autism-like behaviours and social deficits. Long-term potentiation changes in the brain have been proposed as a potential mechanism in the development of autistic behaviour. However, there are controversies regarding the effect of in utero valproic acid exposure on long-term potentiation. This study examined the social interaction and long-term potentiation induction in perforant pathway-dentate gyrus synapses in male offspring of a rat model of autism induced by prenatal exposure to valproic acid. On Embryonic Day 12.5, the pregnant dams received an injection of 500 mg/kg valproic acid (intraperitoneal) to produce the autism model. The sociability test was performed between Postnatal Days 37 and 40. The offsprings were urethane-anaesthetized and placed into a stereotaxic apparatus for surgery, electrode implantation and field potential recording on Postnatal Days 45-55. In the dentate gyrus region, excitatory postsynaptic potential slope and population spike amplitude were measured. Valproic acid-exposed offspring showed significantly impaired social interaction. The birth weight in valproic acid-exposed rats was significantly lower than in control rats. The ability of dentate gyrus synapses to induce long-term potentiation was hampered by valproic acid exposure. The decreasing excitatory postsynaptic potential slope and population spike amplitude of long-term potentiation provide evidence in favour of this notion. It is widely supposed that the hippocampus plays a central role in the process of learning and memory as well as social interaction and social memory. Therefore, deficiencies in hippocampal synaptic plasticity may be responsible, at least in part, for the social interaction deficits in valproic acid-exposed rats." @default.
• W4294607209 created "2022-09-05" @default.
• W4294607209 creator A5005088811 @default.
• W4294607209 creator A5015121741 @default.
• W4294607209 creator A5038214764 @default.
• W4294607209 creator A5057123007 @default.
• W4294607209 creator A5067193944 @default.
• W4294607209 creator A5084771868 @default.
• W4294607209 date "2022-09-01" @default.
• W4294607209 modified "2023-09-30" @default.
• W4294607209 title "Impairment in social interaction and hippocampal long-term potentiation at perforant pathway-dentate gyrus synapses in a prenatal valproic acid-induced rat model of autism" @default.
• W4294607209 cites W1168911763 @default.
• W4294607209 cites W1489333352 @default.
• W4294607209 cites W1572640432 @default.
• W4294607209 cites W1590632482 @default.
• W4294607209 cites W1963978693 @default.
• W4294607209 cites W1967357002 @default.
• W4294607209 cites W1974159198 @default.
• W4294607209 cites W1974772111 @default.
• W4294607209 cites W1979305117 @default.
• W4294607209 cites W1984368478 @default.
• W4294607209 cites W1984520103 @default.
• W4294607209 cites W1985639768 @default.
• W4294607209 cites W1986644762 @default.
• W4294607209 cites W2002012536 @default.
• W4294607209 cites W2008833716 @default.
• W4294607209 cites W2009082639 @default.
• W4294607209 cites W2011382233 @default.
• W4294607209 cites W2011591403 @default.
• W4294607209 cites W2023054061 @default.
• W4294607209 cites W2024636649 @default.
• W4294607209 cites W2027667481 @default.
• W4294607209 cites W2029078015 @default.
• W4294607209 cites W2035132954 @default.
• W4294607209 cites W2037661883 @default.
• W4294607209 cites W2041864652 @default.
• W4294607209 cites W2043414030 @default.
• W4294607209 cites W2047132334 @default.
• W4294607209 cites W2051426370 @default.
• W4294607209 cites W2051519882 @default.
• W4294607209 cites W2051670544 @default.
• W4294607209 cites W2053666202 @default.
• W4294607209 cites W2059199413 @default.
• W4294607209 cites W2065857393 @default.
• W4294607209 cites W2073778279 @default.
• W4294607209 cites W2078222731 @default.
• W4294607209 cites W2080640632 @default.
• W4294607209 cites W2086052356 @default.
• W4294607209 cites W2088352638 @default.
• W4294607209 cites W2097145992 @default.
• W4294607209 cites W2104616895 @default.
• W4294607209 cites W2127317767 @default.
• W4294607209 cites W2128101163 @default.
• W4294607209 cites W2133565799 @default.
• W4294607209 cites W2137154110 @default.
• W4294607209 cites W2143742355 @default.
• W4294607209 cites W2147140183 @default.
• W4294607209 cites W2152652478 @default.
• W4294607209 cites W2155726168 @default.
• W4294607209 cites W2162908902 @default.
• W4294607209 cites W2620781914 @default.
• W4294607209 cites W2770408890 @default.
• W4294607209 cites W2782207560 @default.
• W4294607209 cites W2790470032 @default.
• W4294607209 cites W2797383514 @default.
• W4294607209 cites W2808426286 @default.
• W4294607209 cites W2964654346 @default.
• W4294607209 cites W2969372902 @default.
• W4294607209 cites W2975457683 @default.
• W4294607209 cites W2980918256 @default.
• W4294607209 cites W3093619513 @default.
• W4294607209 cites W3093898976 @default.
• W4294607209 cites W3158375421 @default.
• W4294607209 cites W4224608771 @default.
• W4294607209 doi "https://doi.org/10.1093/braincomms/fcac221" @default.
• W4294607209 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36092302" @default.
• W4294607209 hasPublicationYear "2022" @default.
• W4294607209 type Work @default.
• W4294607209 citedByCount "4" @default.
• W4294607209 countsByYear W42946072092022 @default.
• W4294607209 countsByYear W42946072092023 @default.
• W4294607209 crossrefType "journal-article" @default.
• W4294607209 hasAuthorship W4294607209A5005088811 @default.
• W4294607209 hasAuthorship W4294607209A5015121741 @default.
• W4294607209 hasAuthorship W4294607209A5038214764 @default.
• W4294607209 hasAuthorship W4294607209A5057123007 @default.
• W4294607209 hasAuthorship W4294607209A5067193944 @default.
• W4294607209 hasAuthorship W4294607209A5084771868 @default.
• W4294607209 hasBestOaLocation W42946072091 @default.
• W4294607209 hasConcept C112592302 @default.
• W4294607209 hasConcept C112672928 @default.
• W4294607209 hasConcept C126322002 @default.
• W4294607209 hasConcept C134018914 @default.
• W4294607209 hasConcept C148762608 @default.
• W4294607209 hasConcept C15744967 @default.
• W4294607209 hasConcept C169760540 @default.
• W4294607209 hasConcept C170493617 @default.
• W4294607209 hasConcept C17077164 @default.
• W4294607209 hasConcept C25274449 @default.
• W4294607209 hasConcept C2776168963 @default.

• next