Matches in SemOpenAlex for { <https://semopenalex.org/work/W4294607498> ?p ?o ?g. }
- W4294607498 endingPage "3079" @default.
- W4294607498 startingPage "3066" @default.
- W4294607498 abstract "DNA demethylation and inhibitory effects of aspirin on pituitary cell proliferation have been demonstrated.Our aim was to clarify the molecular mechanisms behind the aspirin-related effects in pituitary cells.DNA methylome and whole transcriptome profile were investigated in RC-4B/C and GH3 pituitary cell lines upon aspirin treatment. Effects of aspirin and a demethylation agent, decitabine, were further tested in vitro. PTTG1 expression in 41 human PitNET samples and whole genome gene and protein expression data of 76 PitNET and 34 control samples (available in Gene Expression Omnibus) were evaluated.Aspirin induced global DNA demethylation and consequential transcriptome changes. Overexpression of Tet enzymes and their cofactor Uhrf2 were identified behind the increase of 5-hydroxymethylcytosine (5hmC). Besides cell cycle, proliferation, and migration effects that were validated by functional experiments, aspirin increased Tp53 activity through p53 acetylation and decreased E2f1 activity. Among the p53 controlled genes, Pttg1 and its interacting partners were downregulated upon aspirin treatment by inhibiting Pttg1 promoter activity. 5hmC positively correlated with Tet1-3 and Tp53 expression, and negatively correlated with Pttg1 expression, which was reinforced by the effect of decitabine. Additionally, high overlap (20.15%) was found between aspirin-regulated genes and dysregulated genes in PitNET tissue samples.A novel regulatory network has been revealed, in which aspirin regulated global demethylation, Tp53 activity, and Pttg1 expression along with decreased cell proliferation and migration. 5hmC, a novel tissue biomarker in PitNET, indicated aspirin antitumoral effect in vitro as well. Our findings suggest the potential beneficial effect of aspirin in PitNET." @default.
- W4294607498 created "2022-09-05" @default.
- W4294607498 creator A5028890269 @default.
- W4294607498 creator A5038176889 @default.
- W4294607498 creator A5042046866 @default.
- W4294607498 creator A5047993836 @default.
- W4294607498 creator A5048063068 @default.
- W4294607498 creator A5066034218 @default.
- W4294607498 creator A5070319989 @default.
- W4294607498 creator A5075024061 @default.
- W4294607498 creator A5075193842 @default.
- W4294607498 creator A5079221711 @default.
- W4294607498 creator A5080017503 @default.
- W4294607498 creator A5081126625 @default.
- W4294607498 creator A5082339467 @default.
- W4294607498 date "2022-09-05" @default.
- W4294607498 modified "2023-10-16" @default.
- W4294607498 title "Aspirin Mediates Its Antitumoral Effect Through Inhibiting PTTG1 in Pituitary Adenoma" @default.
- W4294607498 cites W1583509802 @default.
- W4294607498 cites W1986190002 @default.
- W4294607498 cites W1988877971 @default.
- W4294607498 cites W1999889290 @default.
- W4294607498 cites W2008190138 @default.
- W4294607498 cites W2021512036 @default.
- W4294607498 cites W2027937630 @default.
- W4294607498 cites W2031825556 @default.
- W4294607498 cites W204089053 @default.
- W4294607498 cites W2043223138 @default.
- W4294607498 cites W2044254808 @default.
- W4294607498 cites W2045691764 @default.
- W4294607498 cites W2059084973 @default.
- W4294607498 cites W2063976772 @default.
- W4294607498 cites W2098072500 @default.
- W4294607498 cites W2106482555 @default.
- W4294607498 cites W2120957388 @default.
- W4294607498 cites W2121201545 @default.
- W4294607498 cites W2125253773 @default.
- W4294607498 cites W2130274619 @default.
- W4294607498 cites W2157201048 @default.
- W4294607498 cites W2203513963 @default.
- W4294607498 cites W2252755405 @default.
- W4294607498 cites W2279483485 @default.
- W4294607498 cites W2316560853 @default.
- W4294607498 cites W2567279443 @default.
- W4294607498 cites W2750806321 @default.
- W4294607498 cites W2753171732 @default.
- W4294607498 cites W2806478275 @default.
- W4294607498 cites W2811441922 @default.
- W4294607498 cites W2887672433 @default.
- W4294607498 cites W2889341953 @default.
- W4294607498 cites W2976224211 @default.
- W4294607498 cites W3013988943 @default.
- W4294607498 cites W3014541848 @default.
- W4294607498 cites W3082258006 @default.
- W4294607498 cites W3198942346 @default.
- W4294607498 doi "https://doi.org/10.1210/clinem/dgac496" @default.
- W4294607498 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36059148" @default.
- W4294607498 hasPublicationYear "2022" @default.
- W4294607498 type Work @default.
- W4294607498 citedByCount "2" @default.
- W4294607498 countsByYear W42946074982023 @default.
- W4294607498 crossrefType "journal-article" @default.
- W4294607498 hasAuthorship W4294607498A5028890269 @default.
- W4294607498 hasAuthorship W4294607498A5038176889 @default.
- W4294607498 hasAuthorship W4294607498A5042046866 @default.
- W4294607498 hasAuthorship W4294607498A5047993836 @default.
- W4294607498 hasAuthorship W4294607498A5048063068 @default.
- W4294607498 hasAuthorship W4294607498A5066034218 @default.
- W4294607498 hasAuthorship W4294607498A5070319989 @default.
- W4294607498 hasAuthorship W4294607498A5075024061 @default.
- W4294607498 hasAuthorship W4294607498A5075193842 @default.
- W4294607498 hasAuthorship W4294607498A5079221711 @default.
- W4294607498 hasAuthorship W4294607498A5080017503 @default.
- W4294607498 hasAuthorship W4294607498A5081126625 @default.
- W4294607498 hasAuthorship W4294607498A5082339467 @default.
- W4294607498 hasBestOaLocation W42946074981 @default.
- W4294607498 hasConcept C104317684 @default.
- W4294607498 hasConcept C150194340 @default.
- W4294607498 hasConcept C162317418 @default.
- W4294607498 hasConcept C16824249 @default.
- W4294607498 hasConcept C185592680 @default.
- W4294607498 hasConcept C190727270 @default.
- W4294607498 hasConcept C2777628954 @default.
- W4294607498 hasConcept C2780235182 @default.
- W4294607498 hasConcept C502942594 @default.
- W4294607498 hasConcept C55493867 @default.
- W4294607498 hasConcept C62112901 @default.
- W4294607498 hasConcept C86803240 @default.
- W4294607498 hasConcept C98274493 @default.
- W4294607498 hasConceptScore W4294607498C104317684 @default.
- W4294607498 hasConceptScore W4294607498C150194340 @default.
- W4294607498 hasConceptScore W4294607498C162317418 @default.
- W4294607498 hasConceptScore W4294607498C16824249 @default.
- W4294607498 hasConceptScore W4294607498C185592680 @default.
- W4294607498 hasConceptScore W4294607498C190727270 @default.
- W4294607498 hasConceptScore W4294607498C2777628954 @default.
- W4294607498 hasConceptScore W4294607498C2780235182 @default.
- W4294607498 hasConceptScore W4294607498C502942594 @default.