Matches in SemOpenAlex for { <https://semopenalex.org/work/W4294659899> ?p ?o ?g. }
- W4294659899 abstract "Abstract Chitooligosaccharides (COS) are found naturally in the ocean and present a variety of physiological activities, of which hypoglycemic action has attracted considerable research attention. This study aimed to assess the therapeutic effect of COS on mice suffering from type 2 diabetes mellitus (T2DM). COS effectively reduced blood glucose and blood lipid levels and improved glucose tolerance. Furthermore, COS revealed strong inhibitory activity against α-glucosidase, reducing postprandial blood glucose levels. Molecular docking data showed that COS might interact with surrounding amino acids to form a complex and decrease α-glucosidase activity. Additionally, COS enhanced insulin signal transduction and glycogen synthesis while restricting gluconeogenesis in the liver and muscles, reducing insulin resistance (IR) as a result. Moreover, COS effectively protected and restored islet cell function to increase insulin secretion. These results indicated that COS exhibited a significant hypoglycemic effect with multi-target participation. Therefore, COS may serve as a new preventive or therapeutic drug for diabetes to alleviate metabolic syndrome. Graphical Abstract" @default.
- W4294659899 created "2022-09-06" @default.
- W4294659899 creator A5008978009 @default.
- W4294659899 creator A5014735066 @default.
- W4294659899 creator A5018500008 @default.
- W4294659899 creator A5044410512 @default.
- W4294659899 creator A5053097708 @default.
- W4294659899 creator A5056203586 @default.
- W4294659899 creator A5087406612 @default.
- W4294659899 date "2022-09-05" @default.
- W4294659899 modified "2023-10-18" @default.
- W4294659899 title "Effect of chitooligosaccharides with a specific degree of polymerization on multiple targets in T2DM mice" @default.
- W4294659899 cites W1511417959 @default.
- W4294659899 cites W1826345807 @default.
- W4294659899 cites W1969058624 @default.
- W4294659899 cites W1974719515 @default.
- W4294659899 cites W1975875062 @default.
- W4294659899 cites W1976466305 @default.
- W4294659899 cites W2001581351 @default.
- W4294659899 cites W2005795050 @default.
- W4294659899 cites W2007372685 @default.
- W4294659899 cites W2018471769 @default.
- W4294659899 cites W2020179271 @default.
- W4294659899 cites W2031962983 @default.
- W4294659899 cites W2060347699 @default.
- W4294659899 cites W2060890398 @default.
- W4294659899 cites W2062968305 @default.
- W4294659899 cites W2067185241 @default.
- W4294659899 cites W2086102771 @default.
- W4294659899 cites W2097681320 @default.
- W4294659899 cites W2133222023 @default.
- W4294659899 cites W2147398227 @default.
- W4294659899 cites W2230222215 @default.
- W4294659899 cites W2324713830 @default.
- W4294659899 cites W2475315471 @default.
- W4294659899 cites W2538437447 @default.
- W4294659899 cites W2549132724 @default.
- W4294659899 cites W2588932223 @default.
- W4294659899 cites W2589290067 @default.
- W4294659899 cites W2600326615 @default.
- W4294659899 cites W2680346971 @default.
- W4294659899 cites W2774743973 @default.
- W4294659899 cites W2789850342 @default.
- W4294659899 cites W2794156928 @default.
- W4294659899 cites W2798144734 @default.
- W4294659899 cites W2803965763 @default.
- W4294659899 cites W2877766970 @default.
- W4294659899 cites W2884967083 @default.
- W4294659899 cites W2897277000 @default.
- W4294659899 cites W2901765115 @default.
- W4294659899 cites W2905965925 @default.
- W4294659899 cites W2912734702 @default.
- W4294659899 cites W2923297773 @default.
- W4294659899 cites W2956086379 @default.
- W4294659899 cites W2969203184 @default.
- W4294659899 cites W2979977826 @default.
- W4294659899 cites W2980033472 @default.
- W4294659899 cites W2980798104 @default.
- W4294659899 cites W3002655038 @default.
- W4294659899 cites W3036771678 @default.
- W4294659899 cites W3046880789 @default.
- W4294659899 cites W3092205097 @default.
- W4294659899 cites W4211058450 @default.
- W4294659899 doi "https://doi.org/10.1186/s40643-022-00579-3" @default.
- W4294659899 hasPublicationYear "2022" @default.
- W4294659899 type Work @default.
- W4294659899 citedByCount "0" @default.
- W4294659899 crossrefType "journal-article" @default.
- W4294659899 hasAuthorship W4294659899A5008978009 @default.
- W4294659899 hasAuthorship W4294659899A5014735066 @default.
- W4294659899 hasAuthorship W4294659899A5018500008 @default.
- W4294659899 hasAuthorship W4294659899A5044410512 @default.
- W4294659899 hasAuthorship W4294659899A5053097708 @default.
- W4294659899 hasAuthorship W4294659899A5056203586 @default.
- W4294659899 hasAuthorship W4294659899A5087406612 @default.
- W4294659899 hasBestOaLocation W42946598991 @default.
- W4294659899 hasConcept C126322002 @default.
- W4294659899 hasConcept C134018914 @default.
- W4294659899 hasConcept C185592680 @default.
- W4294659899 hasConcept C20904676 @default.
- W4294659899 hasConcept C2777391703 @default.
- W4294659899 hasConcept C2778199505 @default.
- W4294659899 hasConcept C2779306644 @default.
- W4294659899 hasConcept C55493867 @default.
- W4294659899 hasConcept C555293320 @default.
- W4294659899 hasConcept C62231903 @default.
- W4294659899 hasConcept C71924100 @default.
- W4294659899 hasConcept C86803240 @default.
- W4294659899 hasConcept C98274493 @default.
- W4294659899 hasConceptScore W4294659899C126322002 @default.
- W4294659899 hasConceptScore W4294659899C134018914 @default.
- W4294659899 hasConceptScore W4294659899C185592680 @default.
- W4294659899 hasConceptScore W4294659899C20904676 @default.
- W4294659899 hasConceptScore W4294659899C2777391703 @default.
- W4294659899 hasConceptScore W4294659899C2778199505 @default.
- W4294659899 hasConceptScore W4294659899C2779306644 @default.
- W4294659899 hasConceptScore W4294659899C55493867 @default.
- W4294659899 hasConceptScore W4294659899C555293320 @default.
- W4294659899 hasConceptScore W4294659899C62231903 @default.
- W4294659899 hasConceptScore W4294659899C71924100 @default.