Matches in SemOpenAlex for { <https://semopenalex.org/work/W4294664236> ?p ?o ?g. }
- W4294664236 endingPage "139027" @default.
- W4294664236 startingPage "139027" @default.
- W4294664236 abstract "Amyloid fibrosis of protein is one of protein-related essential issues, which provides the critical information for the diagnosis and therapy of degenerative diseases. Insulin possesses the determined structure and relatively low molecular weight, which is often used as the main model protein to study amyloid fibrosis. Here, we have designed and synthesized three hydrophilic cationic aggregation-induced emission (AIE) probes with different aromatic ketone structures through geminal cross-coupling (GCC) reaction. Cationic AIE molecular probes can bind to insulin fibrils with negative charge at pH = 9.0 through electrostatic interaction, which constrains the intramolecular motion of probes and enhances the fluorescence. The detection limit of probes for insulin fibrils is as low as 0.64 nM. The random and sparse lighting of cationic molecular probes can be realized to enable the super-resolution imaging through the reversible electrostatic association-dissociation interaction between the negative insulin fibrils and positive molecular probes. The fine structure of the fibrils is observed, and full-width at half maximum (FWHM) for assessing the resolution can reach 35 nm, which is of great significance for the development of high-performance super-resolution imaging probes based on aggregation-induced emission and their optical nanoscale visualization applications in the exploration of amyloid fibrillation and related diseases." @default.
- W4294664236 created "2022-09-06" @default.
- W4294664236 creator A5020097730 @default.
- W4294664236 creator A5066432875 @default.
- W4294664236 creator A5071274204 @default.
- W4294664236 creator A5073429660 @default.
- W4294664236 creator A5081331992 @default.
- W4294664236 creator A5088590389 @default.
- W4294664236 creator A5089355761 @default.
- W4294664236 date "2023-01-01" @default.
- W4294664236 modified "2023-10-18" @default.
- W4294664236 title "Cationic molecular probes based on aggregation-induced emission for fluorescent sensing and super-resolution imaging of insulin fibrosis" @default.
- W4294664236 cites W1971094393 @default.
- W4294664236 cites W1987904524 @default.
- W4294664236 cites W1990149084 @default.
- W4294664236 cites W1991169150 @default.
- W4294664236 cites W1992858116 @default.
- W4294664236 cites W1994442356 @default.
- W4294664236 cites W1994724903 @default.
- W4294664236 cites W2001974127 @default.
- W4294664236 cites W2032185182 @default.
- W4294664236 cites W2054455698 @default.
- W4294664236 cites W2077765533 @default.
- W4294664236 cites W2082867654 @default.
- W4294664236 cites W2083624463 @default.
- W4294664236 cites W2089491263 @default.
- W4294664236 cites W2092469837 @default.
- W4294664236 cites W2106395637 @default.
- W4294664236 cites W2115017507 @default.
- W4294664236 cites W2132681327 @default.
- W4294664236 cites W2149241780 @default.
- W4294664236 cites W2167267248 @default.
- W4294664236 cites W2167930632 @default.
- W4294664236 cites W2173062981 @default.
- W4294664236 cites W2177603935 @default.
- W4294664236 cites W2318512529 @default.
- W4294664236 cites W2320931815 @default.
- W4294664236 cites W2422561693 @default.
- W4294664236 cites W2585473308 @default.
- W4294664236 cites W2614053601 @default.
- W4294664236 cites W2790596788 @default.
- W4294664236 cites W2791111928 @default.
- W4294664236 cites W2794224952 @default.
- W4294664236 cites W2797103865 @default.
- W4294664236 cites W2798054687 @default.
- W4294664236 cites W2808508510 @default.
- W4294664236 cites W2888586602 @default.
- W4294664236 cites W2896540448 @default.
- W4294664236 cites W2899516255 @default.
- W4294664236 cites W2904874452 @default.
- W4294664236 cites W2973902849 @default.
- W4294664236 cites W3014697530 @default.
- W4294664236 cites W3044405923 @default.
- W4294664236 cites W3090697926 @default.
- W4294664236 cites W3111824166 @default.
- W4294664236 cites W3152992156 @default.
- W4294664236 doi "https://doi.org/10.1016/j.cej.2022.139027" @default.
- W4294664236 hasPublicationYear "2023" @default.
- W4294664236 type Work @default.
- W4294664236 citedByCount "4" @default.
- W4294664236 countsByYear W42946642362023 @default.
- W4294664236 crossrefType "journal-article" @default.
- W4294664236 hasAuthorship W4294664236A5020097730 @default.
- W4294664236 hasAuthorship W4294664236A5066432875 @default.
- W4294664236 hasAuthorship W4294664236A5071274204 @default.
- W4294664236 hasAuthorship W4294664236A5073429660 @default.
- W4294664236 hasAuthorship W4294664236A5081331992 @default.
- W4294664236 hasAuthorship W4294664236A5088590389 @default.
- W4294664236 hasAuthorship W4294664236A5089355761 @default.
- W4294664236 hasConcept C120665830 @default.
- W4294664236 hasConcept C121332964 @default.
- W4294664236 hasConcept C12554922 @default.
- W4294664236 hasConcept C136238340 @default.
- W4294664236 hasConcept C145169222 @default.
- W4294664236 hasConcept C178790620 @default.
- W4294664236 hasConcept C179104552 @default.
- W4294664236 hasConcept C183882617 @default.
- W4294664236 hasConcept C185592680 @default.
- W4294664236 hasConcept C27523624 @default.
- W4294664236 hasConcept C2777633098 @default.
- W4294664236 hasConcept C552990157 @default.
- W4294664236 hasConcept C55493867 @default.
- W4294664236 hasConcept C86803240 @default.
- W4294664236 hasConcept C91881484 @default.
- W4294664236 hasConceptScore W4294664236C120665830 @default.
- W4294664236 hasConceptScore W4294664236C121332964 @default.
- W4294664236 hasConceptScore W4294664236C12554922 @default.
- W4294664236 hasConceptScore W4294664236C136238340 @default.
- W4294664236 hasConceptScore W4294664236C145169222 @default.
- W4294664236 hasConceptScore W4294664236C178790620 @default.
- W4294664236 hasConceptScore W4294664236C179104552 @default.
- W4294664236 hasConceptScore W4294664236C183882617 @default.
- W4294664236 hasConceptScore W4294664236C185592680 @default.
- W4294664236 hasConceptScore W4294664236C27523624 @default.
- W4294664236 hasConceptScore W4294664236C2777633098 @default.
- W4294664236 hasConceptScore W4294664236C552990157 @default.
- W4294664236 hasConceptScore W4294664236C55493867 @default.
- W4294664236 hasConceptScore W4294664236C86803240 @default.