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• W4294666809 abstract "Abstract Background Although splicing is an integral part of the expression of many genes in our body, genetic syndromes with spliceosomal defects affect only specific tissues. To help understand the mechanism, we investigated the expression pattern of a core protein of the major spliceosome, SmB/B′ (Small Nuclear Ribonucleoprotein Polypeptides B/B′), which is encoded by SNRPB . Loss‐of‐function mutations of SNRPB in humans cause cerebro‐costo‐mandibular syndrome (CCMS) characterized by rib gaps, micrognathia, cleft palate, and scoliosis. Our expression analysis focused on the affected structures as well as non‐affected tissues, using chick and mouse embryos as model animals. Results Embryos at young stages (gastrula) showed ubiquitous expression of SmB/B′. However, the level and pattern of expression became tissue‐specific as differentiation proceeded. The regions relating to CCMS phenotypes such as cartilages of ribs and vertebrae and palatal mesenchyme express SmB/B′ in the nucleus sporadically. However, cartilages that are not affected in CCMS also showed similar expressions. Another spliceosomal gene, SNRNP200 , which mutations cause retinitis pigmentosa, was also prominently expressed in cartilages in addition to the retina. Conclusion The expression of SmB/B′ is spatiotemporally regulated during embryogenesis despite the ubiquitous requirement of the spliceosome, however, the expression pattern is not strictly correlated with the phenotype presentation." @default.
• W4294666809 created "2022-09-06" @default.
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• W4294666809 date "2022-09-20" @default.
• W4294666809 modified "2023-10-17" @default.
• W4294666809 title "Non‐ubiquitous expression of core spliceosomal protein SmB/B′ in chick and mouse embryos" @default.
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• W4294666809 doi "https://doi.org/10.1002/dvdy.537" @default.
• W4294666809 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36058892" @default.
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