FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4294666870> ?p ?o ?g. }

• W4294666870 abstract "Introduction Oculopalatal tremor (OPT) is a late manifestation of a Guillain-Mollaret triangle lesion. Memantine has been shown to improve nystagmus in OPT, but its long-term efficacy and putative distinct effects on each plane of nystagmus and on associated phenomena (e.g., gravity perception) are largely unknown. Methods We conducted a 6-month open-label study to evaluate the effect of memantine in OPT patients. Baseline (visit 1), 2 (visit 2), and 6 months (visit 3) assessments included video-oculography, best corrected visual acuity (BCVA), visual function questionnaire (VFQ25), palatal tremor frequency, and subjective visual vertical (SVV). Memantine was titrated to 20 mg per day and stopped after 6 months. Results We included six patients (5 females; mean age 68.5+/-9.7). At visit 2, nystagmus improved &gt;50% only along the horizontal plane in two patients, while worsening &gt;50% along the vertical and horizontal planes in 4 and 1 patients, respectively. At visit 3, previous improvement of nystagmus along the horizontal plane in two patients was not sustained, and it further worsened &gt;50% along the vertical plane in 4. The mean vertical velocity and amplitude of nystagmus in the left eye significantly worsened from visit 2 to visit 3 ( p = 0.028). Throughout the study, nystagmus frequency remained unchanged ( p = 0.074), BCVA improved in both eyes ( p = 0.047, p = 0.017), SVV progression was unpredictable ( p = 0.513), and the mean VFQ-25 score ( p = 0.223) and mean palatal frequency remained unchanged. Conclusion The long-term use of memantine 20 mg per day in OPT produced a modest and only transient improvement in nystagmus, predominantly along the horizontal plane. Visual acuity improved, albeit without relevant changes in vision-related quality of life." @default.
• W4294666870 created "2022-09-06" @default.
• W4294666870 creator A5001418503 @default.
• W4294666870 creator A5014051875 @default.
• W4294666870 creator A5019977600 @default.
• W4294666870 creator A5024693290 @default.
• W4294666870 creator A5025487045 @default.
• W4294666870 creator A5025923015 @default.
• W4294666870 creator A5031100369 @default.
• W4294666870 creator A5042322159 @default.
• W4294666870 creator A5083914721 @default.
• W4294666870 creator A5089808520 @default.
• W4294666870 date "2022-08-17" @default.
• W4294666870 modified "2023-10-03" @default.
• W4294666870 title "A 6-month trial of memantine for nystagmus and associated phenomena in oculopalatal tremor" @default.
• W4294666870 cites W1772545513 @default.
• W4294666870 cites W1994988724 @default.
• W4294666870 cites W2039031029 @default.
• W4294666870 cites W2085161683 @default.
• W4294666870 cites W2105173064 @default.
• W4294666870 cites W2115435861 @default.
• W4294666870 cites W2167278269 @default.
• W4294666870 cites W2169925926 @default.
• W4294666870 cites W2727477007 @default.
• W4294666870 cites W2779159855 @default.
• W4294666870 cites W2897446479 @default.
• W4294666870 cites W2951613608 @default.
• W4294666870 cites W3039757230 @default.
• W4294666870 cites W3046666862 @default.
• W4294666870 doi "https://doi.org/10.3389/fneur.2022.921341" @default.
• W4294666870 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36061989" @default.
• W4294666870 hasPublicationYear "2022" @default.
• W4294666870 type Work @default.
• W4294666870 citedByCount "0" @default.
• W4294666870 crossrefType "journal-article" @default.
• W4294666870 hasAuthorship W4294666870A5001418503 @default.
• W4294666870 hasAuthorship W4294666870A5014051875 @default.
• W4294666870 hasAuthorship W4294666870A5019977600 @default.
• W4294666870 hasAuthorship W4294666870A5024693290 @default.
• W4294666870 hasAuthorship W4294666870A5025487045 @default.
• W4294666870 hasAuthorship W4294666870A5025923015 @default.
• W4294666870 hasAuthorship W4294666870A5031100369 @default.
• W4294666870 hasAuthorship W4294666870A5042322159 @default.
• W4294666870 hasAuthorship W4294666870A5083914721 @default.
• W4294666870 hasAuthorship W4294666870A5089808520 @default.
• W4294666870 hasBestOaLocation W42946668701 @default.
• W4294666870 hasConcept C118487528 @default.
• W4294666870 hasConcept C126322002 @default.
• W4294666870 hasConcept C170493617 @default.
• W4294666870 hasConcept C2778257484 @default.
• W4294666870 hasConcept C2779484449 @default.
• W4294666870 hasConcept C2779736392 @default.
• W4294666870 hasConcept C548259974 @default.
• W4294666870 hasConcept C67018056 @default.
• W4294666870 hasConcept C71924100 @default.
• W4294666870 hasConceptScore W4294666870C118487528 @default.
• W4294666870 hasConceptScore W4294666870C126322002 @default.
• W4294666870 hasConceptScore W4294666870C170493617 @default.
• W4294666870 hasConceptScore W4294666870C2778257484 @default.
• W4294666870 hasConceptScore W4294666870C2779484449 @default.
• W4294666870 hasConceptScore W4294666870C2779736392 @default.
• W4294666870 hasConceptScore W4294666870C548259974 @default.
• W4294666870 hasConceptScore W4294666870C67018056 @default.
• W4294666870 hasConceptScore W4294666870C71924100 @default.
• W4294666870 hasLocation W42946668701 @default.
• W4294666870 hasLocation W42946668702 @default.
• W4294666870 hasOpenAccess W4294666870 @default.
• W4294666870 hasPrimaryLocation W42946668701 @default.
• W4294666870 hasRelatedWork W2008444812 @default.
• W4294666870 hasRelatedWork W2054045640 @default.
• W4294666870 hasRelatedWork W2100804585 @default.
• W4294666870 hasRelatedWork W2121102661 @default.
• W4294666870 hasRelatedWork W2349999257 @default.
• W4294666870 hasRelatedWork W2354275354 @default.
• W4294666870 hasRelatedWork W2378097720 @default.
• W4294666870 hasRelatedWork W2378578596 @default.
• W4294666870 hasRelatedWork W2706556910 @default.
• W4294666870 hasRelatedWork W1990315214 @default.
• W4294666870 hasVolume "13" @default.
• W4294666870 isParatext "false" @default.
• W4294666870 isRetracted "false" @default.
• W4294666870 workType "article" @default.