Matches in SemOpenAlex for { <https://semopenalex.org/work/W4294667242> ?p ?o ?g. }
- W4294667242 endingPage "629" @default.
- W4294667242 startingPage "613" @default.
- W4294667242 abstract "In this study, an adipic acid dihydrazide (ADH)/ tannic acid (TA)-grafted hyaluronic acid (HA)-based multifunctional hydrogel was synthesized through a spontaneous amino-yne click reaction and used to promote the improved healing of infected diabetic wounds. This hydrogel exhibited a range of beneficial properties such as tunable gelation time, adjustable mechanical properties, pH-sensitive response characteristics, excellent injectability, the ability to readily adhere to tissue, and ultra-intimate contact capabilities. Following the encapsulation of ultrasmall Ag nanoclusters (AgNCs) and deferoxamine loaded polydopamine/ hollow mesoporous manganese dioxide (PHMD, PDA/H-mMnO2@DFO) nanoparticles, the prepared hydrogel presented with robust antibacterial, anti-inflammatory, and pro-angiogenic properties and a desirable smart drug release profile. In this fabricated platform, PHMD was able to effectively alleviate localized oxidative stress and prolonged oxygen deprivation via the decomposition of endogenous H2O2 to produce O2. Further in vivo assays revealed that this hydrogel was capable of facilitating the healing of infected wounds through the sequential engagement of antibacterial, anti-inflammatory, and pro-angiogenic activities. Together, this synthesized clickable environmentally-responsive hydrogel offers great promise as a tool that can be applied to aid in the healing of chronically infected diabetic wounds and other inflammatory conditions." @default.
- W4294667242 created "2022-09-06" @default.
- W4294667242 creator A5027209324 @default.
- W4294667242 creator A5037310600 @default.
- W4294667242 creator A5050117569 @default.
- W4294667242 creator A5052085461 @default.
- W4294667242 creator A5059148084 @default.
- W4294667242 creator A5064142583 @default.
- W4294667242 creator A5074131487 @default.
- W4294667242 creator A5075880057 @default.
- W4294667242 creator A5079594267 @default.
- W4294667242 creator A5083441730 @default.
- W4294667242 date "2022-10-01" @default.
- W4294667242 modified "2023-10-18" @default.
- W4294667242 title "Clickable and smart drug delivery vehicles accelerate the healing of infected diabetic wounds" @default.
- W4294667242 cites W1773615136 @default.
- W4294667242 cites W1926350625 @default.
- W4294667242 cites W1935012038 @default.
- W4294667242 cites W1968477302 @default.
- W4294667242 cites W1972831716 @default.
- W4294667242 cites W2007435978 @default.
- W4294667242 cites W2049882917 @default.
- W4294667242 cites W2056692572 @default.
- W4294667242 cites W2061073363 @default.
- W4294667242 cites W2099039284 @default.
- W4294667242 cites W2119778962 @default.
- W4294667242 cites W2144623505 @default.
- W4294667242 cites W2229796655 @default.
- W4294667242 cites W2237248201 @default.
- W4294667242 cites W2376936448 @default.
- W4294667242 cites W2395249393 @default.
- W4294667242 cites W2401893904 @default.
- W4294667242 cites W2413193118 @default.
- W4294667242 cites W2489906103 @default.
- W4294667242 cites W2527719646 @default.
- W4294667242 cites W2529013366 @default.
- W4294667242 cites W2563183592 @default.
- W4294667242 cites W2599366142 @default.
- W4294667242 cites W2734377645 @default.
- W4294667242 cites W2764028271 @default.
- W4294667242 cites W2771974389 @default.
- W4294667242 cites W2776403397 @default.
- W4294667242 cites W2785382519 @default.
- W4294667242 cites W2790653789 @default.
- W4294667242 cites W2793801139 @default.
- W4294667242 cites W2801035947 @default.
- W4294667242 cites W2804376496 @default.
- W4294667242 cites W2883477868 @default.
- W4294667242 cites W2887985416 @default.
- W4294667242 cites W2890899782 @default.
- W4294667242 cites W2899967263 @default.
- W4294667242 cites W2900935986 @default.
- W4294667242 cites W2909505539 @default.
- W4294667242 cites W2926912834 @default.
- W4294667242 cites W2997036886 @default.
- W4294667242 cites W3008175617 @default.
- W4294667242 cites W3015385912 @default.
- W4294667242 cites W3037181905 @default.
- W4294667242 cites W3037692118 @default.
- W4294667242 cites W3040499085 @default.
- W4294667242 cites W3042414108 @default.
- W4294667242 cites W3114256717 @default.
- W4294667242 cites W3122301016 @default.
- W4294667242 cites W3133005132 @default.
- W4294667242 cites W3139358517 @default.
- W4294667242 cites W3151408156 @default.
- W4294667242 cites W3164079031 @default.
- W4294667242 cites W3165916650 @default.
- W4294667242 cites W3182336228 @default.
- W4294667242 cites W3186164548 @default.
- W4294667242 cites W3191658494 @default.
- W4294667242 cites W3195672774 @default.
- W4294667242 cites W3215886254 @default.
- W4294667242 cites W3216337629 @default.
- W4294667242 cites W3217028211 @default.
- W4294667242 cites W4200026682 @default.
- W4294667242 cites W4205277607 @default.
- W4294667242 cites W4213059900 @default.
- W4294667242 cites W4213075605 @default.
- W4294667242 cites W4223975395 @default.
- W4294667242 cites W4224435961 @default.
- W4294667242 cites W4224884088 @default.
- W4294667242 cites W4239923255 @default.
- W4294667242 doi "https://doi.org/10.1016/j.jconrel.2022.08.053" @default.
- W4294667242 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36058354" @default.
- W4294667242 hasPublicationYear "2022" @default.
- W4294667242 type Work @default.
- W4294667242 citedByCount "15" @default.
- W4294667242 countsByYear W42946672422023 @default.
- W4294667242 crossrefType "journal-article" @default.
- W4294667242 hasAuthorship W4294667242A5027209324 @default.
- W4294667242 hasAuthorship W4294667242A5037310600 @default.
- W4294667242 hasAuthorship W4294667242A5050117569 @default.
- W4294667242 hasAuthorship W4294667242A5052085461 @default.
- W4294667242 hasAuthorship W4294667242A5059148084 @default.
- W4294667242 hasAuthorship W4294667242A5064142583 @default.
- W4294667242 hasAuthorship W4294667242A5074131487 @default.
- W4294667242 hasAuthorship W4294667242A5075880057 @default.