Matches in SemOpenAlex for { <https://semopenalex.org/work/W4294667246> ?p ?o ?g. }
- W4294667246 endingPage "252" @default.
- W4294667246 startingPage "241" @default.
- W4294667246 abstract "Background: Ewing sarcoma (ES) can be confirmed by identifying the EWSR1-FLI1 fusion transcript. This study is to investigate whether immunostaining (IHC) of PRKCB—a protein directly regulated by EWSR1-FLI1 is a surrogate maker for diagnosing ES in routine practice. Methods: Microarray gene expression analyses were conducted. RKCB IHC was applied to 69 ES confirmed by morphology and molecular methods, and 41 non-Ewing small round cell tumors. EWSR1 rearrangement, EWSR1-FLI1 fusion or t(11;22)(q24;q12) were identified by fluorescence in situ hybridization, reverse transcriptase polymerase chain reaction, or cytogenetic analysis, respectively. Results: Gene array analyses showed significant overexpression of the PRKCB in ES. PRKCB IHC was positive in 19 cases of ES with EWSR1-FLI1 fusion, 3 cases with cytogenetic 11:22 translocation and 59 cases with EWSR1 rearrangement while negative in only one EWSR1 rearranged case. PRKCB IHC is sensitive (98%) and specific (96%) in detecting EWSR1 rearranged ES. Conclusions: PRKCB is a reliable antibody for diagnosing ES in routine practice." @default.
- W4294667246 created "2022-09-06" @default.
- W4294667246 creator A5013676019 @default.
- W4294667246 creator A5017208495 @default.
- W4294667246 creator A5022728544 @default.
- W4294667246 creator A5027642211 @default.
- W4294667246 creator A5033559851 @default.
- W4294667246 creator A5035616597 @default.
- W4294667246 creator A5043205942 @default.
- W4294667246 creator A5045834689 @default.
- W4294667246 creator A5061602647 @default.
- W4294667246 creator A5078927422 @default.
- W4294667246 creator A5080487628 @default.
- W4294667246 date "2022-09-05" @default.
- W4294667246 modified "2023-09-24" @default.
- W4294667246 title "Validation of PRKCB Immunohistochemistry as a Biomarker for the Diagnosis of Ewing Sarcoma" @default.
- W4294667246 cites W115673842 @default.
- W4294667246 cites W1640846578 @default.
- W4294667246 cites W1955222620 @default.
- W4294667246 cites W1973195150 @default.
- W4294667246 cites W1975760666 @default.
- W4294667246 cites W1988968354 @default.
- W4294667246 cites W2015025893 @default.
- W4294667246 cites W2019806781 @default.
- W4294667246 cites W2022352188 @default.
- W4294667246 cites W2027739413 @default.
- W4294667246 cites W2030466057 @default.
- W4294667246 cites W2033392236 @default.
- W4294667246 cites W2043516602 @default.
- W4294667246 cites W2051833743 @default.
- W4294667246 cites W2068402552 @default.
- W4294667246 cites W2069351898 @default.
- W4294667246 cites W2087286808 @default.
- W4294667246 cites W2087630768 @default.
- W4294667246 cites W2090915824 @default.
- W4294667246 cites W2096113686 @default.
- W4294667246 cites W2101127767 @default.
- W4294667246 cites W2101854267 @default.
- W4294667246 cites W2112156135 @default.
- W4294667246 cites W2134738900 @default.
- W4294667246 cites W2134945705 @default.
- W4294667246 cites W2140334256 @default.
- W4294667246 cites W2142878985 @default.
- W4294667246 cites W2151444534 @default.
- W4294667246 cites W2167516123 @default.
- W4294667246 cites W2170407716 @default.
- W4294667246 cites W2512464445 @default.
- W4294667246 cites W2793084223 @default.
- W4294667246 cites W2960614029 @default.
- W4294667246 cites W3042086219 @default.
- W4294667246 doi "https://doi.org/10.1080/15513815.2022.2117579" @default.
- W4294667246 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36062956" @default.
- W4294667246 hasPublicationYear "2022" @default.
- W4294667246 type Work @default.
- W4294667246 citedByCount "0" @default.
- W4294667246 crossrefType "journal-article" @default.
- W4294667246 hasAuthorship W4294667246A5013676019 @default.
- W4294667246 hasAuthorship W4294667246A5017208495 @default.
- W4294667246 hasAuthorship W4294667246A5022728544 @default.
- W4294667246 hasAuthorship W4294667246A5027642211 @default.
- W4294667246 hasAuthorship W4294667246A5033559851 @default.
- W4294667246 hasAuthorship W4294667246A5035616597 @default.
- W4294667246 hasAuthorship W4294667246A5043205942 @default.
- W4294667246 hasAuthorship W4294667246A5045834689 @default.
- W4294667246 hasAuthorship W4294667246A5061602647 @default.
- W4294667246 hasAuthorship W4294667246A5078927422 @default.
- W4294667246 hasAuthorship W4294667246A5080487628 @default.
- W4294667246 hasConcept C104317684 @default.
- W4294667246 hasConcept C111829193 @default.
- W4294667246 hasConcept C138626823 @default.
- W4294667246 hasConcept C142724271 @default.
- W4294667246 hasConcept C153911025 @default.
- W4294667246 hasConcept C204232928 @default.
- W4294667246 hasConcept C2776295783 @default.
- W4294667246 hasConcept C2777542201 @default.
- W4294667246 hasConcept C2777586341 @default.
- W4294667246 hasConcept C2777937962 @default.
- W4294667246 hasConcept C2778256501 @default.
- W4294667246 hasConcept C2778274637 @default.
- W4294667246 hasConcept C30481170 @default.
- W4294667246 hasConcept C4224716 @default.
- W4294667246 hasConcept C49105822 @default.
- W4294667246 hasConcept C54355233 @default.
- W4294667246 hasConcept C71924100 @default.
- W4294667246 hasConcept C86803240 @default.
- W4294667246 hasConceptScore W4294667246C104317684 @default.
- W4294667246 hasConceptScore W4294667246C111829193 @default.
- W4294667246 hasConceptScore W4294667246C138626823 @default.
- W4294667246 hasConceptScore W4294667246C142724271 @default.
- W4294667246 hasConceptScore W4294667246C153911025 @default.
- W4294667246 hasConceptScore W4294667246C204232928 @default.
- W4294667246 hasConceptScore W4294667246C2776295783 @default.
- W4294667246 hasConceptScore W4294667246C2777542201 @default.
- W4294667246 hasConceptScore W4294667246C2777586341 @default.
- W4294667246 hasConceptScore W4294667246C2777937962 @default.
- W4294667246 hasConceptScore W4294667246C2778256501 @default.
- W4294667246 hasConceptScore W4294667246C2778274637 @default.
- W4294667246 hasConceptScore W4294667246C30481170 @default.