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- W4294671563 abstract "Humans have co-existed with parasites for virtually the entirety of our existence as a species. Today, nearly one third of the human population is infected with at least one helminthic species, most of which reside in the intestinal tract, where they have co-evolved alongside the human gut microbiota (GM). Appreciation for the interconnected relationship between helminths and GM has increased in recent years. Here, we review the evidence of how helminths and GM can influence various aspects of childhood development and the onset of paediatric diseases. We discuss the emerging evidence of how many of the changes that parasitic worms inflict on their host is enacted through gut microbes. In this light, we argue that helminth-induced microbiota modifications are of great importance in both facing the global challenge of overcoming parasitic infections, and in replicating helminthic protective effects against inflammatory diseases. We propose that deepening our knowledge of helminth-microbiota interactions will uncover novel, safer and more effective therapeutic strategies in combatting an array of childhood disorders." @default.
- W4294671563 created "2022-09-06" @default.
- W4294671563 creator A5018186381 @default.
- W4294671563 creator A5087292162 @default.
- W4294671563 date "2022-09-19" @default.
- W4294671563 modified "2023-10-14" @default.
- W4294671563 title "Impact of helminth–microbiome interactions on childhood health and development—A clinical perspective" @default.
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