Matches in SemOpenAlex for { <https://semopenalex.org/work/W4294671567> ?p ?o ?g. }
- W4294671567 endingPage "26" @default.
- W4294671567 startingPage "22" @default.
- W4294671567 abstract "Psoriasis vulgaris is a chronic, relapsing, inflammatory disorder marked by an intensified immune response. The role of immunogenetics in psoriasis is still poorly understood; however, experts agree that its expression depends on proinflammatory cytokines.Forkhead box class O3A (FOXO3a), a transcription factor, plays a crucial role in intercellular regulation, oxidative stress, deoxyribonucleic acid (DNA) repair, and cell death.The objective of this study was to investigate the role of FOXO3a genetic polymorphism as a risk factor for psoriasis vulgaris and assess its possible relationship with disease severity.A comparative case-control study included 53 patients with psoriasis and 41 matched healthy controls. We measured serum FOXO3a levels and used the PCR-RFLEP technique to detect FOXO3a genetic polymorphism (rs13217795) in both groups.Our results revealed significantly higher serum FOXO3a levels in the psoriasis group compared to the control group (p≤0.001). Serum FOXO3a levels were significantly higher in patients with severe psoriasis than in those with mild-to-moderate disease. FOXO3a genotypes found homozygous mutant genotype (TT) was substantially more frequent in the psoriasis group than in the control group. Furthermore, the T allele was more frequent in the psoriasis group than in the control group.The study indicates that rs13217795 polymorphism of the FOXO3a gene is strongly associated with susceptibility to psoriasis. Also, the serum level of FOXO3a is significantly higher in patients with severe psoriasis, compared to patients with mild-to-moderate psoriasis. This finding could be an area of future targeted therapy." @default.
- W4294671567 created "2022-09-06" @default.
- W4294671567 creator A5010292951 @default.
- W4294671567 creator A5029753713 @default.
- W4294671567 creator A5060646691 @default.
- W4294671567 creator A5068123215 @default.
- W4294671567 creator A5069391857 @default.
- W4294671567 date "2022-08-01" @default.
- W4294671567 modified "2023-09-28" @default.
- W4294671567 title "The Association Between Forkhead Box Class O3A Gene Polymorphism and Psoriasis and Its Relationship with Psoriasis Severity." @default.
- W4294671567 cites W1820314031 @default.
- W4294671567 cites W1905701786 @default.
- W4294671567 cites W1964995490 @default.
- W4294671567 cites W1968405676 @default.
- W4294671567 cites W1969658448 @default.
- W4294671567 cites W1972186163 @default.
- W4294671567 cites W1973358400 @default.
- W4294671567 cites W1974740739 @default.
- W4294671567 cites W1991577519 @default.
- W4294671567 cites W1993836723 @default.
- W4294671567 cites W1997273242 @default.
- W4294671567 cites W2020877539 @default.
- W4294671567 cites W2021018799 @default.
- W4294671567 cites W2024953482 @default.
- W4294671567 cites W2026270670 @default.
- W4294671567 cites W2043035301 @default.
- W4294671567 cites W2043957215 @default.
- W4294671567 cites W2050172669 @default.
- W4294671567 cites W2057030367 @default.
- W4294671567 cites W2064091851 @default.
- W4294671567 cites W2075427507 @default.
- W4294671567 cites W2076174368 @default.
- W4294671567 cites W2087589809 @default.
- W4294671567 cites W2087616494 @default.
- W4294671567 cites W2095441854 @default.
- W4294671567 cites W2101348176 @default.
- W4294671567 cites W2103120331 @default.
- W4294671567 cites W2106686862 @default.
- W4294671567 cites W2108958930 @default.
- W4294671567 cites W2126569401 @default.
- W4294671567 cites W2134606556 @default.
- W4294671567 cites W2137035181 @default.
- W4294671567 cites W2137563421 @default.
- W4294671567 cites W2149095946 @default.
- W4294671567 cites W2160047041 @default.
- W4294671567 cites W2556845933 @default.
- W4294671567 cites W2561759163 @default.
- W4294671567 cites W2606625725 @default.
- W4294671567 cites W2807983683 @default.
- W4294671567 cites W3099663356 @default.
- W4294671567 cites W3173226927 @default.
- W4294671567 cites W4211202219 @default.
- W4294671567 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36061485" @default.
- W4294671567 hasPublicationYear "2022" @default.
- W4294671567 type Work @default.
- W4294671567 citedByCount "1" @default.
- W4294671567 countsByYear W42946715672023 @default.
- W4294671567 crossrefType "journal-article" @default.
- W4294671567 hasAuthorship W4294671567A5010292951 @default.
- W4294671567 hasAuthorship W4294671567A5029753713 @default.
- W4294671567 hasAuthorship W4294671567A5060646691 @default.
- W4294671567 hasAuthorship W4294671567A5068123215 @default.
- W4294671567 hasAuthorship W4294671567A5069391857 @default.
- W4294671567 hasConcept C104317684 @default.
- W4294671567 hasConcept C126322002 @default.
- W4294671567 hasConcept C135763542 @default.
- W4294671567 hasConcept C146304588 @default.
- W4294671567 hasConcept C164027704 @default.
- W4294671567 hasConcept C180754005 @default.
- W4294671567 hasConcept C203014093 @default.
- W4294671567 hasConcept C2776914184 @default.
- W4294671567 hasConcept C2780564577 @default.
- W4294671567 hasConcept C54355233 @default.
- W4294671567 hasConcept C71924100 @default.
- W4294671567 hasConcept C76252995 @default.
- W4294671567 hasConcept C86803240 @default.
- W4294671567 hasConceptScore W4294671567C104317684 @default.
- W4294671567 hasConceptScore W4294671567C126322002 @default.
- W4294671567 hasConceptScore W4294671567C135763542 @default.
- W4294671567 hasConceptScore W4294671567C146304588 @default.
- W4294671567 hasConceptScore W4294671567C164027704 @default.
- W4294671567 hasConceptScore W4294671567C180754005 @default.
- W4294671567 hasConceptScore W4294671567C203014093 @default.
- W4294671567 hasConceptScore W4294671567C2776914184 @default.
- W4294671567 hasConceptScore W4294671567C2780564577 @default.
- W4294671567 hasConceptScore W4294671567C54355233 @default.
- W4294671567 hasConceptScore W4294671567C71924100 @default.
- W4294671567 hasConceptScore W4294671567C76252995 @default.
- W4294671567 hasConceptScore W4294671567C86803240 @default.
- W4294671567 hasIssue "8" @default.
- W4294671567 hasLocation W42946715671 @default.
- W4294671567 hasOpenAccess W4294671567 @default.
- W4294671567 hasPrimaryLocation W42946715671 @default.
- W4294671567 hasRelatedWork W2020364677 @default.
- W4294671567 hasRelatedWork W2053948114 @default.
- W4294671567 hasRelatedWork W2065901679 @default.
- W4294671567 hasRelatedWork W2077397494 @default.
- W4294671567 hasRelatedWork W2119264823 @default.