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• W4294723979 abstract "Objectives Since the first description of the Median Arcuate Ligament Syndrome (MALS), the existence of the syndrome and the efficacy of treatment have been questioned. Methods We have performed a systematic review conform the PRISMA Statement with a broader view on treatment for MALS including any kind of CA release, coeliac plexus resection and coeliac plexus blockage irrespective of age. Online databases were used to identify papers published between 1963 and July 2021. Inclusion criteria were: abdominal symptoms, prove of MALS on imaging, articles reporting on at least three patients. Primary outcomes were symptom relief and Quality of Life (QoL). Results Thirty-eight studies describing 880 adult patients and 6 studies describing 195 paediatric patients were included. The majority of the adult studies reported a symptom relief >70% from 3 to 228 months after treatment. Two adult studies showed an improved QoL after treatment. Half of the paediatric studies reported a symptom relief >70% from 6 to 62 months after laparoscopic CA release and four studies reported an improved QoL. Thirty-five (92%) adult studies and five (83%) paediatric studies scored a high or unclear risk of bias for the majority of the QUADAS-2 items. The meaning of coeliac plexus resection or blockage couldn’t be substantiated. Conclusions This systematic review suggests a sustainable symptom relief above 70% after treatment for MALS in the majority of the adult and paediatric studies but due to the heterogenicity of the inclusion criteria and outcome parameters the risk of bias is high and a formal meta-analysis cannot be performed. To improve care for patients with MALS the next steps would be to deal with reporting standards, outcome definitions and consensus descriptions of the intervention(s) after which an appropriate randomized controlled trial can be performed." @default.
• W4294723979 created "2022-09-06" @default.
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• W4294723979 date "2022-12-01" @default.
• W4294723979 modified "2023-09-25" @default.
• W4294723979 title "Systematic Review of the Efficacy of Treatment for Median Arcuate Ligament Syndrome" @default.
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• W4294723979 doi "https://doi.org/10.1016/j.ejvs.2022.08.033" @default.
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