FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4294731460> ?p ?o ?g. }

• W4294731460 abstract "Abstract The golden hamster ( Mesocricetus auratus ) is commonly used as a promising model for Leishmania braziliensis infection developing skin‐ulcerated lesions. However, different protocols using high concentration of parasites inoculated in the footpad result in severe clinical disease. Here, we further investigate the outcome of the site of infection and concentration of L. braziliensis parasites inoculated on the immunopathogenesis and clinical evolution. Initially, hamsters were infected in the ear dermis or hind footpad with a concentration of 1 × 10 5 parasites. Animals infected in the ear dermis developed a disease, with an increased parasite load that more closely resembled human cutaneous leishmaniasis lesions comparing to the group infected in the footpad. Next, we evaluated if different parasite concentrations (10 4 , 10 5 and 10 6 ) inoculated in the ear dermis would impact the course and clinical aspects of infection. Hamsters infected with 10 4 and 10 5 parasites developed mild lesions compared to the group infected with 10 6 that presented severe and persistent lesions. The parasite load varied between the different parasite concentrations. The inflammatory response was more intense when infection was initiated with 10 6 parasites accompanied by an increased initial expression of IL‐4, IL‐10 and arginase in the lymph node followed by expression of both pro‐and anti‐inflammatory cytokines comparing to groups infected with 10 4 and 10 5 parasites. In conclusion, the number of parasites inoculated, and the initial site of infection could influence the inflammatory response, and clinical presentation. Our results suggest that the ear dermis infection model induces a chronic disease that relates to immunopathological aspects of CL natural infection." @default.
• W4294731460 created "2022-09-06" @default.
• W4294731460 creator A5002798958 @default.
• W4294731460 creator A5009400545 @default.
• W4294731460 creator A5010630798 @default.
• W4294731460 creator A5011876786 @default.
• W4294731460 creator A5026694433 @default.
• W4294731460 creator A5047004244 @default.
• W4294731460 creator A5055409177 @default.
• W4294731460 creator A5080194479 @default.
• W4294731460 creator A5087739498 @default.
• W4294731460 creator A5088837499 @default.
• W4294731460 date "2022-09-23" @default.
• W4294731460 modified "2023-09-26" @default.
• W4294731460 title "Different inoculum of<i>Leishmania braziliensis</i>concentrations influence immunopathogenesis and clinical evolution in the ear dermis hamster model of cutaneous leishmaniasis" @default.
• W4294731460 cites W1515941168 @default.
• W4294731460 cites W1868085246 @default.
• W4294731460 cites W1962521045 @default.
• W4294731460 cites W1964264884 @default.
• W4294731460 cites W1982436950 @default.
• W4294731460 cites W1984776625 @default.
• W4294731460 cites W1994345083 @default.
• W4294731460 cites W2011237115 @default.
• W4294731460 cites W2011445312 @default.
• W4294731460 cites W2018623169 @default.
• W4294731460 cites W2019296702 @default.
• W4294731460 cites W2039316360 @default.
• W4294731460 cites W2040404169 @default.
• W4294731460 cites W2040879781 @default.
• W4294731460 cites W2059032518 @default.
• W4294731460 cites W2061961359 @default.
• W4294731460 cites W2064273736 @default.
• W4294731460 cites W2076835818 @default.
• W4294731460 cites W2082067617 @default.
• W4294731460 cites W2085969762 @default.
• W4294731460 cites W2124411826 @default.
• W4294731460 cites W2133936370 @default.
• W4294731460 cites W2139045037 @default.
• W4294731460 cites W2139616386 @default.
• W4294731460 cites W2140736098 @default.
• W4294731460 cites W2148221436 @default.
• W4294731460 cites W2150531122 @default.
• W4294731460 cites W2153254832 @default.
• W4294731460 cites W2162623444 @default.
• W4294731460 cites W2162680854 @default.
• W4294731460 cites W2168416755 @default.
• W4294731460 cites W2170316996 @default.
• W4294731460 cites W2186123618 @default.
• W4294731460 cites W2327222213 @default.
• W4294731460 cites W2408175870 @default.
• W4294731460 cites W2413702251 @default.
• W4294731460 cites W2474120059 @default.
• W4294731460 cites W2475849143 @default.
• W4294731460 cites W2626102211 @default.
• W4294731460 doi "https://doi.org/10.1111/pim.12947" @default.
• W4294731460 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36057920" @default.
• W4294731460 hasPublicationYear "2022" @default.
• W4294731460 type Work @default.
• W4294731460 citedByCount "0" @default.
• W4294731460 crossrefType "journal-article" @default.
• W4294731460 hasAuthorship W4294731460A5002798958 @default.
• W4294731460 hasAuthorship W4294731460A5009400545 @default.
• W4294731460 hasAuthorship W4294731460A5010630798 @default.
• W4294731460 hasAuthorship W4294731460A5011876786 @default.
• W4294731460 hasAuthorship W4294731460A5026694433 @default.
• W4294731460 hasAuthorship W4294731460A5047004244 @default.
• W4294731460 hasAuthorship W4294731460A5055409177 @default.
• W4294731460 hasAuthorship W4294731460A5080194479 @default.
• W4294731460 hasAuthorship W4294731460A5087739498 @default.
• W4294731460 hasAuthorship W4294731460A5088837499 @default.
• W4294731460 hasConcept C105702510 @default.
• W4294731460 hasConcept C136764020 @default.
• W4294731460 hasConcept C142724271 @default.
• W4294731460 hasConcept C153911025 @default.
• W4294731460 hasConcept C203014093 @default.
• W4294731460 hasConcept C2775993617 @default.
• W4294731460 hasConcept C2776555147 @default.
• W4294731460 hasConcept C2777624698 @default.
• W4294731460 hasConcept C2777735729 @default.
• W4294731460 hasConcept C2778575167 @default.
• W4294731460 hasConcept C2778702967 @default.
• W4294731460 hasConcept C2779525107 @default.
• W4294731460 hasConcept C2780599195 @default.
• W4294731460 hasConcept C2781092759 @default.
• W4294731460 hasConcept C41008148 @default.
• W4294731460 hasConcept C71924100 @default.
• W4294731460 hasConcept C71928629 @default.
• W4294731460 hasConcept C86803240 @default.
• W4294731460 hasConcept C8891405 @default.
• W4294731460 hasConceptScore W4294731460C105702510 @default.
• W4294731460 hasConceptScore W4294731460C136764020 @default.
• W4294731460 hasConceptScore W4294731460C142724271 @default.
• W4294731460 hasConceptScore W4294731460C153911025 @default.
• W4294731460 hasConceptScore W4294731460C203014093 @default.
• W4294731460 hasConceptScore W4294731460C2775993617 @default.
• W4294731460 hasConceptScore W4294731460C2776555147 @default.
• W4294731460 hasConceptScore W4294731460C2777624698 @default.
• W4294731460 hasConceptScore W4294731460C2777735729 @default.
• W4294731460 hasConceptScore W4294731460C2778575167 @default.
• W4294731460 hasConceptScore W4294731460C2778702967 @default.

• next