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• W4294733691 startingPage "10096" @default.
• W4294733691 abstract "Neuroinflammation, where inflammatory cytokines are produced in excess, contributes to the pathogenesis of delirium. Microglial cells play a central role in neuroinflammation by producing and releasing inflammatory cytokines in response to infection, tissue damage and neurodegeneration. Dexmedetomidine (DEX) is a sedative, which reduces the incidence of delirium. Thus, we hypothesized that DEX may alleviate delirium by exhibiting anti-inflammatory action on microglia. In the present study, we investigated the anti-inflammatory action of DEX on human microglial HMC3 cells. The results indicated that DEX partially suppressed the IL-6 and IL-8 production by lipopolysaccharide (LPS)-stimulated HMC3 cells as well as the phosphorylation of p38 MAPK and IκB and the translocation of NF-κB. Furthermore, DEX substantially suppressed IL-6 and IL-8 production by unstimulated HMC3 cells as wells as the phosphorylation of p38 MAPK and IκB and the translocation of NF-κB. These observations suggest that DEX exhibits anti-inflammatory action on not only LPS-stimulated but also unstimulated microglial cells via the suppression of inflammatory signaling and cytokine production." @default.
• W4294733691 created "2022-09-06" @default.
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• W4294733691 date "2022-09-03" @default.
• W4294733691 modified "2023-09-25" @default.
• W4294733691 title "Anti-Inflammatory Action of Dexmedetomidine on Human Microglial Cells" @default.
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• W4294733691 doi "https://doi.org/10.3390/ijms231710096" @default.
• W4294733691 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36077505" @default.
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