FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4294754911> ?p ?o ?g. }

• W4294754911 endingPage "598" @default.
• W4294754911 startingPage "589" @default.
• W4294754911 abstract "Objective: The effectiveness of tissue engineering materials combining porcine small intestine submucosa (SIS) and umbilical cord mesenchymal stem cells (UC-MSCs) on uterine injury in female rat after full-thickness uterine resection was evaluated as a basis for clinical treatment of postoperative uterine injury. Methods: After complex culture with SIS and UC-MSCs, cell adhesion, growth, and proliferation were assessed. Before the implantation, a surgical procedure of bilateral full-thickness uterine resection (0.5-2.0 cm long and 0.3 cm wide) was performed to obtain the rat uterine injury model, while the sham-operated rats were used as controls. Hematoxylin-eosin (H&E) staining results and fertility of female rats in each group were assessed to determine the critical resection length of the full-thickness uterine resection. Then SIS or UC-MSCs-SIS were implanted into the female rats from the uterine injury group, followed by assessments of H&E staining, the expression of ki67, α-SMA, and leukemia inhibitory factor (LIF), and fertility to determine the effectiveness of SIS and UC-MSCs-SIS on uterine injury in female rat. Results: At 24, 48, and 72 h, the cells grew progressively on the SIS material. In the 1.5 cm and 2.0 cm groups, the pregnancy rate, proportion of the uterus supporting live embryo growth, number of live embryos, and proportion of live embryos were all significantly less than those in the 0.5 cm and sham-operated groups. In the 2.0 cm group, there was little tissue regeneration at the center of the injury and not conducive to subsequent assessment. The UC-MSCs-SIS and SIS groups were better on morphological development, cell proliferation, LIF expression, and fertility than the control group. Conclusions: UC-MSCs show good adhesion, growth, and proliferation on the SIS scaffold material. The optimal resection length in full-thickness uterine resection on female rat is 1.5 cm. UC-MSCs-SIS is the effective treatment for repairing a injury after the full-thickness resection of the uterus in this research. Impact Statement The acquired severe uterus injury is a serious condition, which prone to uterine adhesions. Postoperative endometrial repairment and prevention of intrauterine adhesion recurrence are two major clinical challenges. Fortunately, the development of tissue engineering technology makes repairing a uterine injury possible. There are two main contributions from this study. First, due to ethical requirements, it is difficult to assess the repairing effect on uterus by invasive experiments in a clinical practice. Therefore, we constructed a full-thickness uterine injury rat model, which allows us to assess the repairing effect of treatments after severe uterine injuries in vivo. Second, it explored the effect of using a combination of and umbilical cord mesenchymal stem cells and small intestine submucosa materials on improving uterine repairments, providing a potential possibility for a future clinical practice." @default.
• W4294754911 created "2022-09-06" @default.
• W4294754911 creator A5005806482 @default.
• W4294754911 creator A5008447895 @default.
• W4294754911 creator A5026403752 @default.
• W4294754911 creator A5062626548 @default.
• W4294754911 creator A5067673946 @default.
• W4294754911 creator A5088008274 @default.
• W4294754911 date "2022-11-01" @default.
• W4294754911 modified "2023-10-06" @default.
• W4294754911 title "Umbilical Cord Mesenchymal Stem Cells Seeded on Small Intestinal Submucosa to Repair the Uterine Wall Injuries" @default.
• W4294754911 cites W1520986136 @default.
• W4294754911 cites W1996016116 @default.
• W4294754911 cites W1999042962 @default.
• W4294754911 cites W2019637355 @default.
• W4294754911 cites W2036348189 @default.
• W4294754911 cites W2049252866 @default.
• W4294754911 cites W2061954405 @default.
• W4294754911 cites W2095335313 @default.
• W4294754911 cites W2099486691 @default.
• W4294754911 cites W2148842379 @default.
• W4294754911 cites W2563623080 @default.
• W4294754911 cites W2591692261 @default.
• W4294754911 cites W2605949967 @default.
• W4294754911 cites W2739160196 @default.
• W4294754911 cites W2765298464 @default.
• W4294754911 cites W2805438999 @default.
• W4294754911 cites W2840917343 @default.
• W4294754911 cites W2911567764 @default.
• W4294754911 cites W2943025875 @default.
• W4294754911 cites W2945622636 @default.
• W4294754911 cites W2965900422 @default.
• W4294754911 cites W3028099709 @default.
• W4294754911 cites W3028348313 @default.
• W4294754911 cites W3040846933 @default.
• W4294754911 cites W3131221168 @default.
• W4294754911 cites W3157110536 @default.
• W4294754911 doi "https://doi.org/10.1089/ten.tec.2022.0007" @default.
• W4294754911 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36066337" @default.
• W4294754911 hasPublicationYear "2022" @default.
• W4294754911 type Work @default.
• W4294754911 citedByCount "1" @default.
• W4294754911 countsByYear W42947549112023 @default.
• W4294754911 crossrefType "journal-article" @default.
• W4294754911 hasAuthorship W4294754911A5005806482 @default.
• W4294754911 hasAuthorship W4294754911A5008447895 @default.
• W4294754911 hasAuthorship W4294754911A5026403752 @default.
• W4294754911 hasAuthorship W4294754911A5062626548 @default.
• W4294754911 hasAuthorship W4294754911A5067673946 @default.
• W4294754911 hasAuthorship W4294754911A5088008274 @default.
• W4294754911 hasConcept C105702510 @default.
• W4294754911 hasConcept C11988809 @default.
• W4294754911 hasConcept C125473707 @default.
• W4294754911 hasConcept C126322002 @default.
• W4294754911 hasConcept C141071460 @default.
• W4294754911 hasConcept C142724271 @default.
• W4294754911 hasConcept C16685009 @default.
• W4294754911 hasConcept C198826908 @default.
• W4294754911 hasConcept C204232928 @default.
• W4294754911 hasConcept C27284151 @default.
• W4294754911 hasConcept C2776914184 @default.
• W4294754911 hasConcept C2776955114 @default.
• W4294754911 hasConcept C2778227567 @default.
• W4294754911 hasConcept C2779052585 @default.
• W4294754911 hasConcept C2779066055 @default.
• W4294754911 hasConcept C28328180 @default.
• W4294754911 hasConcept C3017725331 @default.
• W4294754911 hasConcept C54355233 @default.
• W4294754911 hasConcept C71924100 @default.
• W4294754911 hasConcept C86803240 @default.
• W4294754911 hasConceptScore W4294754911C105702510 @default.
• W4294754911 hasConceptScore W4294754911C11988809 @default.
• W4294754911 hasConceptScore W4294754911C125473707 @default.
• W4294754911 hasConceptScore W4294754911C126322002 @default.
• W4294754911 hasConceptScore W4294754911C141071460 @default.
• W4294754911 hasConceptScore W4294754911C142724271 @default.
• W4294754911 hasConceptScore W4294754911C16685009 @default.
• W4294754911 hasConceptScore W4294754911C198826908 @default.
• W4294754911 hasConceptScore W4294754911C204232928 @default.
• W4294754911 hasConceptScore W4294754911C27284151 @default.
• W4294754911 hasConceptScore W4294754911C2776914184 @default.
• W4294754911 hasConceptScore W4294754911C2776955114 @default.
• W4294754911 hasConceptScore W4294754911C2778227567 @default.
• W4294754911 hasConceptScore W4294754911C2779052585 @default.
• W4294754911 hasConceptScore W4294754911C2779066055 @default.
• W4294754911 hasConceptScore W4294754911C28328180 @default.
• W4294754911 hasConceptScore W4294754911C3017725331 @default.
• W4294754911 hasConceptScore W4294754911C54355233 @default.
• W4294754911 hasConceptScore W4294754911C71924100 @default.
• W4294754911 hasConceptScore W4294754911C86803240 @default.
• W4294754911 hasIssue "11" @default.
• W4294754911 hasLocation W42947549111 @default.
• W4294754911 hasLocation W42947549112 @default.
• W4294754911 hasOpenAccess W4294754911 @default.
• W4294754911 hasPrimaryLocation W42947549111 @default.
• W4294754911 hasRelatedWork W2054352305 @default.
• W4294754911 hasRelatedWork W2363549010 @default.
• W4294754911 hasRelatedWork W2366319831 @default.

• next