Matches in SemOpenAlex for { <https://semopenalex.org/work/W4294769910> ?p ?o ?g. }
- W4294769910 endingPage "373" @default.
- W4294769910 startingPage "353" @default.
- W4294769910 abstract "AbstractIn this chapter, we review electrical and morphological properties of lumbar motoneurons during postnatal development in wild-type (WT) and transgenic superoxide dismutase 1 (SOD1) mice, models of amyotrophic lateral sclerosis. First we showed that sensorimotor reflexes do not develop normally in transgenic SOD1G85R pups. Fictive locomotor activity recorded in in vitro whole brainstem/spinal cord preparations was not induced in these transgenic SOD1G85R mice using NMDA and 5HT in contrast to WT mice. Further, abnormal electrical properties were detected as early as the second postnatal week in lumbar motoneurons of SOD1 mice while they develop clinical symptoms several months after birth. We compared two different strains of mice (G85R and G93A) at the same postnatal period using intracellular recordings and patch clamp recordings of WT and SOD1 motoneurons. We defined three types of motoneurons according to their discharge firing pattern (transient, sustained and delayed onset firing) when motor units are not yet mature. The delayed-onset firing motoneurons had the higher rheobase compared to the transient and sustained firing groups in the WT mice. We demonstrated hypoexcitability in the delayed onset-firing motoneurons of SOD1 mice. Intracellular staining of motoneurons revealed dendritic overbranching in SOD1 lumbar motoneurons that was more pronounced in the sustained firing motoneurons. We suggested that motoneuronal hypoexcitability is an early pathological sign affecting a subset of lumbar motoneurons in the spinal cord of SOD1 mice.KeywordsSpinal cordALSSOD1 transgenic miceHypoexcitabilityMotor neuron" @default.
- W4294769910 created "2022-09-06" @default.
- W4294769910 creator A5044442206 @default.
- W4294769910 creator A5045670728 @default.
- W4294769910 date "2022-01-01" @default.
- W4294769910 modified "2023-10-01" @default.
- W4294769910 title "Electrical and Morphological Properties of Developing Motoneurons in Postnatal Mice and Early Abnormalities in SOD1 Transgenic Mice" @default.
- W4294769910 cites W1494206301 @default.
- W4294769910 cites W1561893572 @default.
- W4294769910 cites W1607372012 @default.
- W4294769910 cites W164763019 @default.
- W4294769910 cites W1757661894 @default.
- W4294769910 cites W1852853462 @default.
- W4294769910 cites W1936093460 @default.
- W4294769910 cites W1967085353 @default.
- W4294769910 cites W1969556684 @default.
- W4294769910 cites W1970534588 @default.
- W4294769910 cites W1971086844 @default.
- W4294769910 cites W1974795616 @default.
- W4294769910 cites W1978639846 @default.
- W4294769910 cites W1981215594 @default.
- W4294769910 cites W1983387285 @default.
- W4294769910 cites W1988713735 @default.
- W4294769910 cites W1990349957 @default.
- W4294769910 cites W2000353630 @default.
- W4294769910 cites W2002731409 @default.
- W4294769910 cites W2006462017 @default.
- W4294769910 cites W2012851706 @default.
- W4294769910 cites W2013135033 @default.
- W4294769910 cites W2018110972 @default.
- W4294769910 cites W2023113196 @default.
- W4294769910 cites W2024297410 @default.
- W4294769910 cites W2024313201 @default.
- W4294769910 cites W2026372988 @default.
- W4294769910 cites W2031639005 @default.
- W4294769910 cites W2036386442 @default.
- W4294769910 cites W2036483462 @default.
- W4294769910 cites W2042052064 @default.
- W4294769910 cites W2045132169 @default.
- W4294769910 cites W2047066220 @default.
- W4294769910 cites W2047239277 @default.
- W4294769910 cites W2047867249 @default.
- W4294769910 cites W2049890992 @default.
- W4294769910 cites W2051260283 @default.
- W4294769910 cites W2051982487 @default.
- W4294769910 cites W2052068870 @default.
- W4294769910 cites W2057139034 @default.
- W4294769910 cites W2057759463 @default.
- W4294769910 cites W2058183189 @default.
- W4294769910 cites W2059178369 @default.
- W4294769910 cites W2064966625 @default.
- W4294769910 cites W2067015275 @default.
- W4294769910 cites W2070720564 @default.
- W4294769910 cites W2071417504 @default.
- W4294769910 cites W2077244931 @default.
- W4294769910 cites W2085204538 @default.
- W4294769910 cites W2085938738 @default.
- W4294769910 cites W2088329659 @default.
- W4294769910 cites W2093990877 @default.
- W4294769910 cites W2094608970 @default.
- W4294769910 cites W2096386031 @default.
- W4294769910 cites W2097334085 @default.
- W4294769910 cites W2099720070 @default.
- W4294769910 cites W2101970831 @default.
- W4294769910 cites W2104493972 @default.
- W4294769910 cites W2106526071 @default.
- W4294769910 cites W2107065376 @default.
- W4294769910 cites W2107315373 @default.
- W4294769910 cites W2107768418 @default.
- W4294769910 cites W2108048080 @default.
- W4294769910 cites W2119667852 @default.
- W4294769910 cites W2123003659 @default.
- W4294769910 cites W2123779560 @default.
- W4294769910 cites W2126370635 @default.
- W4294769910 cites W2129829859 @default.
- W4294769910 cites W2131105283 @default.
- W4294769910 cites W2132498101 @default.
- W4294769910 cites W2133232170 @default.
- W4294769910 cites W2134440736 @default.
- W4294769910 cites W2137980029 @default.
- W4294769910 cites W2140183904 @default.
- W4294769910 cites W2141587041 @default.
- W4294769910 cites W2142521845 @default.
- W4294769910 cites W2144475886 @default.
- W4294769910 cites W2145172575 @default.
- W4294769910 cites W2151525547 @default.
- W4294769910 cites W2153120212 @default.
- W4294769910 cites W2158621084 @default.
- W4294769910 cites W2160414529 @default.
- W4294769910 cites W2162843814 @default.
- W4294769910 cites W2168049429 @default.
- W4294769910 cites W2169604722 @default.
- W4294769910 cites W2170076941 @default.
- W4294769910 cites W2178120923 @default.
- W4294769910 cites W2188606760 @default.
- W4294769910 cites W2189151548 @default.
- W4294769910 cites W2317226401 @default.
- W4294769910 cites W2396446279 @default.