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• W4294770726 endingPage "105224" @default.
• W4294770726 startingPage "105224" @default.
• W4294770726 abstract "The study investigated the effects of quercetin and putative mechanisms involved against endosulfan-testicular impairments in rats. Rats were allotted into five treatment groups (n = 5). Groups 1-2 had normal saline and maize oil (vehicle) (10 mL/kg), group 3 received quercetin (20 mg/kg), 4-5 had endosulfan (5 mg/kg, p.o) orally for 28 days. However, from days 14-28, group 4 received an additional dose of vehicle (10 mL/kg, p.o./day), while group 5 received quercetin (20 mg/kg, p.o./day). Thereafter, blood samples and testes were harvested for markers of cholinergic, hormonal and testicular oxido-nitrergic, inflammatory, apoptosis and proton pump ATPase activities. Also, testicular histopathological changes were also evaluated alongside with germ cell count, testicular injury and spermatogenesis score. Quercetin increased testicular/body weights and spermatogenesis, androgenic hormones (follicle stimulating hormones, FSH; luteinizing hormone, LH; testosterone), acetylcholinesterase levels and attenuated altered membrane integrity, DNA fragmentation, increased caspases-3 levels in rats exposed to endosulfan. Moreover, quercetin increased testicular B-cell lymphoma-2 (Bcl-2), Bcl-2 associated x-protein (Bax) and proton pump adenosine trisphosphate (ATPase) and sialic acid levels. Of note, quercetin reversed endosulfan-mediated increased malondialdehyde, nitrite, peroxynitrite formation, 8-hydroxy-2'-deoxyguanosine and lowered antioxidant enzymes in the testes. The increased levels of testicular myeloperoxidase (MPO), tumor necrosis factor-alpha (TNF-α) and interleukin-1beta (IL-1β) by endosulfan were also reduced by quercetin administration. Additionally, quercetin attenuate endosulfan-induced testicular histopathological changes of rats. Our findings showed that quercetin significantly inhibited endosulfan-induced testicular damage and altered spermatogenesis through inhibition of oxido-nitrergic pathway, inflammatory mediators, apoptosis, acetylcholinesterase activity and enhancement of testicular hormones and improvement in testicular ATPase activity." @default.
• W4294770726 created "2022-09-06" @default.
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• W4294770726 date "2022-11-01" @default.
• W4294770726 modified "2023-09-26" @default.
• W4294770726 title "Possible mechanisms involved in the testicular-protective property of quercetin in rats exposed to endosulfan toxicity" @default.
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• W4294770726 cites W1750690213 @default.
• W4294770726 cites W1775749144 @default.
• W4294770726 cites W1826724865 @default.
• W4294770726 cites W1965007708 @default.
• W4294770726 cites W1967569950 @default.
• W4294770726 cites W1971048984 @default.
• W4294770726 cites W1977258127 @default.
• W4294770726 cites W1977597523 @default.
• W4294770726 cites W1986494891 @default.
• W4294770726 cites W1993489262 @default.
• W4294770726 cites W2013840030 @default.
• W4294770726 cites W2022345186 @default.
• W4294770726 cites W2022818203 @default.
• W4294770726 cites W2025853996 @default.
• W4294770726 cites W2029549580 @default.
• W4294770726 cites W2033288357 @default.
• W4294770726 cites W2034596741 @default.
• W4294770726 cites W2042114947 @default.
• W4294770726 cites W2045052972 @default.
• W4294770726 cites W2050090966 @default.
• W4294770726 cites W2050306350 @default.
• W4294770726 cites W2052566349 @default.
• W4294770726 cites W2052948427 @default.
• W4294770726 cites W2058699904 @default.
• W4294770726 cites W2063576996 @default.
• W4294770726 cites W2064783007 @default.
• W4294770726 cites W2067622426 @default.
• W4294770726 cites W2071998961 @default.
• W4294770726 cites W2079300009 @default.
• W4294770726 cites W2080446780 @default.
• W4294770726 cites W2097918205 @default.
• W4294770726 cites W2115118119 @default.
• W4294770726 cites W2137062669 @default.
• W4294770726 cites W2155840484 @default.
• W4294770726 cites W2168084392 @default.
• W4294770726 cites W2309009498 @default.
• W4294770726 cites W2322719278 @default.
• W4294770726 cites W2565494467 @default.
• W4294770726 cites W2569799760 @default.
• W4294770726 cites W2759536256 @default.
• W4294770726 cites W2794198598 @default.
• W4294770726 cites W2795513227 @default.
• W4294770726 cites W2803709482 @default.
• W4294770726 cites W2809086266 @default.
• W4294770726 cites W2911439844 @default.
• W4294770726 cites W2921029053 @default.
• W4294770726 cites W2946099490 @default.
• W4294770726 cites W2956268538 @default.
• W4294770726 cites W2969107098 @default.
• W4294770726 cites W2974231197 @default.
• W4294770726 cites W2975394805 @default.
• W4294770726 cites W2979498530 @default.
• W4294770726 cites W2990319247 @default.
• W4294770726 cites W2997032704 @default.
• W4294770726 cites W2997162941 @default.
• W4294770726 cites W3011251699 @default.
• W4294770726 cites W3012049280 @default.
• W4294770726 cites W3012608664 @default.
• W4294770726 cites W3016294380 @default.
• W4294770726 cites W3024119345 @default.
• W4294770726 cites W3087185369 @default.
• W4294770726 cites W3121037873 @default.
• W4294770726 cites W3127433418 @default.
• W4294770726 cites W3147601650 @default.
• W4294770726 cites W3199726259 @default.
• W4294770726 cites W3201170651 @default.
• W4294770726 cites W4200455255 @default.
• W4294770726 cites W4205522604 @default.
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• W4294770726 doi "https://doi.org/10.1016/j.pestbp.2022.105224" @default.
• W4294770726 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36464344" @default.
• W4294770726 hasPublicationYear "2022" @default.
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