Matches in SemOpenAlex for { <https://semopenalex.org/work/W4294771625> ?p ?o ?g. }
- W4294771625 endingPage "111309" @default.
- W4294771625 startingPage "111309" @default.
- W4294771625 abstract "Dysfunctional dopamine signaling is implicated in various neuropsychological disorders. Previously, we reported that dopamine increases D1 receptor (D1R)-expressing medium spiny neuron (MSN) excitability and firing rates in the nucleus accumbens (NAc) via the PKA/Rap1/ERK pathway to promote reward behavior. Here, the results show that the D1R agonist, SKF81297, inhibits KCNQ-mediated currents and increases D1R-MSN firing rates in murine NAc slices, which is abolished by ERK inhibition. In vitro ERK phosphorylates KCNQ2 at Ser414 and Ser476; in vivo, KCNQ2 is phosphorylated downstream of dopamine signaling in NAc slices. Conditional deletion of Kcnq2 in D1R-MSNs reduces the inhibitory effect of SKF81297 on KCNQ channel activity, while enhancing neuronal excitability and cocaine-induced reward behavior. These effects are restored by wild-type, but not phospho-deficient KCNQ2. Hence, D1R-ERK signaling controls MSN excitability via KCNQ2 phosphorylation to regulate reward behavior, making KCNQ2 a potential therapeutical target for psychiatric diseases with a dysfunctional reward circuit." @default.
- W4294771625 created "2022-09-06" @default.
- W4294771625 creator A5004827664 @default.
- W4294771625 creator A5012487815 @default.
- W4294771625 creator A5016597293 @default.
- W4294771625 creator A5016609147 @default.
- W4294771625 creator A5020306754 @default.
- W4294771625 creator A5030309677 @default.
- W4294771625 creator A5031889786 @default.
- W4294771625 creator A5044977732 @default.
- W4294771625 creator A5050390075 @default.
- W4294771625 creator A5054775721 @default.
- W4294771625 creator A5070814001 @default.
- W4294771625 creator A5074635182 @default.
- W4294771625 creator A5080973494 @default.
- W4294771625 creator A5081097443 @default.
- W4294771625 creator A5081667624 @default.
- W4294771625 creator A5086048520 @default.
- W4294771625 creator A5086222815 @default.
- W4294771625 creator A5088049227 @default.
- W4294771625 date "2022-09-01" @default.
- W4294771625 modified "2023-10-18" @default.
- W4294771625 title "Dopamine drives neuronal excitability via KCNQ channel phosphorylation for reward behavior" @default.
- W4294771625 cites W1488533758 @default.
- W4294771625 cites W1519847602 @default.
- W4294771625 cites W1600323537 @default.
- W4294771625 cites W1736719008 @default.
- W4294771625 cites W1945424073 @default.
- W4294771625 cites W1973788414 @default.
- W4294771625 cites W1977917700 @default.
- W4294771625 cites W1997537641 @default.
- W4294771625 cites W2002668453 @default.
- W4294771625 cites W2006036568 @default.
- W4294771625 cites W2018239076 @default.
- W4294771625 cites W2019734375 @default.
- W4294771625 cites W2021704663 @default.
- W4294771625 cites W2032909298 @default.
- W4294771625 cites W2033382270 @default.
- W4294771625 cites W2041848110 @default.
- W4294771625 cites W2056543335 @default.
- W4294771625 cites W2062506960 @default.
- W4294771625 cites W2068942851 @default.
- W4294771625 cites W2069501671 @default.
- W4294771625 cites W2071032731 @default.
- W4294771625 cites W2075588319 @default.
- W4294771625 cites W2076506821 @default.
- W4294771625 cites W2077241702 @default.
- W4294771625 cites W2083307540 @default.
- W4294771625 cites W2084452628 @default.
- W4294771625 cites W2094902307 @default.
- W4294771625 cites W2114715627 @default.
- W4294771625 cites W2118336207 @default.
- W4294771625 cites W2145594774 @default.
- W4294771625 cites W2162891493 @default.
- W4294771625 cites W2165909414 @default.
- W4294771625 cites W2167021628 @default.
- W4294771625 cites W2168659826 @default.
- W4294771625 cites W2256079339 @default.
- W4294771625 cites W2274414600 @default.
- W4294771625 cites W2520619796 @default.
- W4294771625 cites W2696588002 @default.
- W4294771625 cites W2899048073 @default.
- W4294771625 cites W2945670811 @default.
- W4294771625 cites W2991836460 @default.
- W4294771625 cites W3007736386 @default.
- W4294771625 cites W3036856342 @default.
- W4294771625 cites W3112166428 @default.
- W4294771625 cites W3124198441 @default.
- W4294771625 cites W3172705911 @default.
- W4294771625 cites W3201039003 @default.
- W4294771625 cites W4200258579 @default.
- W4294771625 cites W4200335359 @default.
- W4294771625 doi "https://doi.org/10.1016/j.celrep.2022.111309" @default.
- W4294771625 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36070693" @default.
- W4294771625 hasPublicationYear "2022" @default.
- W4294771625 type Work @default.
- W4294771625 citedByCount "4" @default.
- W4294771625 countsByYear W42947716252022 @default.
- W4294771625 countsByYear W42947716252023 @default.
- W4294771625 crossrefType "journal-article" @default.
- W4294771625 hasAuthorship W4294771625A5004827664 @default.
- W4294771625 hasAuthorship W4294771625A5012487815 @default.
- W4294771625 hasAuthorship W4294771625A5016597293 @default.
- W4294771625 hasAuthorship W4294771625A5016609147 @default.
- W4294771625 hasAuthorship W4294771625A5020306754 @default.
- W4294771625 hasAuthorship W4294771625A5030309677 @default.
- W4294771625 hasAuthorship W4294771625A5031889786 @default.
- W4294771625 hasAuthorship W4294771625A5044977732 @default.
- W4294771625 hasAuthorship W4294771625A5050390075 @default.
- W4294771625 hasAuthorship W4294771625A5054775721 @default.
- W4294771625 hasAuthorship W4294771625A5070814001 @default.
- W4294771625 hasAuthorship W4294771625A5074635182 @default.
- W4294771625 hasAuthorship W4294771625A5080973494 @default.
- W4294771625 hasAuthorship W4294771625A5081097443 @default.
- W4294771625 hasAuthorship W4294771625A5081667624 @default.
- W4294771625 hasAuthorship W4294771625A5086048520 @default.
- W4294771625 hasAuthorship W4294771625A5086222815 @default.
- W4294771625 hasAuthorship W4294771625A5088049227 @default.