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- W4294783513 abstract "Abstract Complement factor H (CFH) is an abundant serum protein regulating complement activation and protecting host cells from attack by the alternative pathway of complement mediated cytotoxicity. We previously identified an anti-CFH autoantibody in early stage NSCLC patients, and cloned from single peripheral B cells a lead therapeutic mAb, GT103, for cancer immunotherapy. Although GT103 has potent antitumor activities, the underlying antitumor mechanisms remain unknown. Herein we investigated GT103-mediated antitumor effects and demonstrate that GT103 enhances antitumor immunity through multiple pathways. GT103 treatment creates a favorable tumor microenvironment (TME) by decreasing immunosuppressive regulatory T cells and myeloid-derived suppressor cells and enhancing antigen-specific effector T cells and has a synergistic antitumor effect with anti-PD-L1 mAb. Furthermore, the immune landscape of tumors from early stage patients expressing the anti-CFH autoantibody is associated with an immunologically active TME. Our results provide novel mechanistic insights into this promising human-derived immunotherapeutic agent, which is currently undergoing a Phase I/II clinical trial in patients with NSCLC." @default.
- W4294783513 created "2022-09-06" @default.
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- W4294783513 date "2022-09-06" @default.
- W4294783513 modified "2023-09-24" @default.
- W4294783513 title "Creation of a Favorable Antitumor Microenvironment by the Anti-Complement Factor H Antibody GT103" @default.
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- W4294783513 doi "https://doi.org/10.21203/rs.3.rs-2001920/v1" @default.
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