Matches in SemOpenAlex for { <https://semopenalex.org/work/W4294796930> ?p ?o ?g. }
- W4294796930 endingPage "105087" @default.
- W4294796930 startingPage "105087" @default.
- W4294796930 abstract "The G protein-coupled receptor 84 (GPR84) is found in immune cells and its expression is increased under inflammatory conditions. Activation of GPR84 by medium-chain fatty acids results in pro-inflammatory responses. Here, we screened available vertebrate genome data and found that GPR84 is present in vertebrates for more than 500 million years but absent in birds and a pseudogene in bats. Cloning and functional characterization of several mammalian GPR84 orthologs in combination with evolutionary and model-based structural analyses revealed evidence for positive selection of bear GPR84 orthologs. Naturally occurring human GPR84 variants are most frequent in Asian populations causing a loss of function. Further, we identified cis- and trans-2-decenoic acid, both known to mediate bacterial communication, as evolutionary highly conserved ligands. Our integrated set of approaches contributes to a comprehensive understanding of GPR84 in terms of evolutionary and structural aspects, highlighting GPR84 as a conserved immune cell receptor for bacteria-derived molecules." @default.
- W4294796930 created "2022-09-06" @default.
- W4294796930 creator A5007342314 @default.
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- W4294796930 date "2022-10-01" @default.
- W4294796930 modified "2023-09-30" @default.
- W4294796930 title "Evolutionary analyses reveal immune cell receptor GPR84 as a conserved receptor for bacteria-derived molecules" @default.
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