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• W4294805033 abstract "Background Cardiovascular (CV) risk factors can be transmitted from mothers to their children. However, it is challenging to measure and identify subclinical CV risk in young children using traditional CV risk methods and metrics. Objective The purpose of this study was to determine the feasibility of recruiting mother-child dyads and measuring arterial stiffness (pulse wave velocity, augmentation index/pressure), blood pressure (BP), BP circadian pattern, specifically nocturnal BP dipping, and CV health metrics in mothers and in children aged 1 to 5 years. Methods All BP and arterial stiffness measures were obtained using the noninvasive automated oscillometric Mobil-O-Graph device. Also measured were blood cholesterol level; glucose level; body mass index (BMI); and smoking, diet, and physical activity history. Descriptive statistics were used for assessing recruitment feasibility and Pearson correlations for mother-child associations. Results Thirty-five mother-child dyads completed the protocol. Recruitment reach was 89% and retention rate was 80%. Mothers were 34.3 ± 5.4 years old with a mean systolic BP (SBP) of 114.6 ± 9.5 mm Hg and BMI of 26.0 ± 6.5. Children were 3 ± 1.4 years old with a mean SBP of 103.3 ± 9.4 mm Hg and BMI z-scores of −0.3 ± 1.5. Arterial stiffness parameters were within normal ranges for mothers and children. Twenty-three percent of mothers did not exhibit nocturnal dipping (<10% decrease between day and nighttime SBP). Maternal SBP was positively correlated with child BMI z-scores (r = 0.42, P = .022) as well as mother-child augmentation pressure (r = 0.51, P = .010). Conclusions Our findings support using a mother-child approach and novel noninvasive approaches to assess and target CV risk in mothers and their young children." @default.
• W4294805033 created "2022-09-06" @default.
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• W4294805033 date "2022-09-02" @default.
• W4294805033 modified "2023-09-26" @default.
• W4294805033 title "A Mother-Child Dyadic Approach to Evaluating Subclinical Cardiovascular Disease in Young Children" @default.
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• W4294805033 doi "https://doi.org/10.1097/jcn.0000000000000944" @default.
• W4294805033 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36066587" @default.
• W4294805033 hasPublicationYear "2022" @default.
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