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- W4294816721 abstract "Emerging evidence demonstrated that Sirt1 (silent information regulator 1) is an enzyme involved in several anti-aging pathways, such as DNA deacetylation and repair, metabolic regulation, mitochondrial biogenesis, and thus a preserved cell function that may favor longevity. Lifelong exercise may be associated with attenuation in Sirt1 decrease and biological aging. PURPOSE: The present study aimed to verify possible associations between Sirt1 and chronological age of both untrained and lifelong sprint trained middle-aged individuals. We hypothesized that age-related Sirt1 decrease could be attenuated in master sprinters. METHODS: Master sprinters (MS) from athletics (n = 35; age: 50.25 ± 5.93), as well as young non-athletes (YU) (n = 32; age: 23.78 ± 3.98) and untrained middle-aged individuals (MU) (n = 24; age: 47.29 ± 8.04) took part in the study. Venous blood collections were performed for Sirt1 analysis, using a specific ELISA kit (Abcam, São Paulo, Brazil). Analysis of Variance and Pearson's Correlation Coefficient were applied for results interpretation, with a significance level of p ≤ 0.05. RESULTS: Sirt1 levels of MS were significantly higher than their untrained peers [17.18 ± 4.77 vs. 6.36 ± 2.29 ng·mL-1 (p < 0.0001)], and did not differ from YU [20.26 ± 6.20 ng·mL-1 (p = 0.066)]. A negative correlation was found between Sirt1 and chronological age (r = -0.735; p < 0.0001) for untrained YU and MA individuals. However, when Sirt1 levels of MS were analyzed together with those of YU, that significant relationship between Sirt1 and chronological age was lost (r = -0.243; p = 0.083), evidencing an attenuation on age-related decrease in Sirt1, possibly due the effects of lifelong training decelerating biological aging. CONCLUSION: In this transversal analysis, master athletes demonstrated attenuation in the age-related decline in Sirt1. Lifelong exercise seems to preserve Sirt1 levels for master sprinters of presente study, what in turn may be related to attenuated biological aging, as evidenced previously through preserved telomere length in this population. Future studies on the exercise dose-response should be conducted for a better understanding of mechanisms as well for a better choice of exercise mode, volume and intensities as anti-aging strategies." @default.
- W4294816721 created "2022-09-06" @default.
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- W4294816721 date "2022-09-01" @default.
- W4294816721 modified "2023-10-16" @default.
- W4294816721 title "Age-related Decline In Sirt1 Is Attenuated In Master Sprinters" @default.
- W4294816721 doi "https://doi.org/10.1249/01.mss.0000882900.22684.32" @default.
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