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- W4294816887 abstract "Hepcidin is a peptide hormone that plays a key role in down-regulating iron metabolism (Nemeth et al. 2004). Endurance training under heat condition (i.e., heat acclimation training) improved thermoregulatory function and endurance capacity (Lorenzo et al. 2010), whereas it remains unclear how heat acclimation affects hepcidin response with exercise under heat condition. PURPOSE: We determined the effect of heat acclimation on endurance exercise-induced hepcidin elevation under heat condition. METHODS: Fifteen healthy males were divided into two groups: 1) endurance training under heat condition (HOT, 35 °C, n = 8) or 2) endurance training under cool condition (CON, 18 °C, n = 7). All subjects completed 2 weeks of endurance training period (8 sessions in total), consisted of 60 min continuous exercise at 50% of maximal oxygen uptake in each environment. Before and after the training period, heat stress exercise test (60 min exercise at 60% VO2max, HST) was conducted to evaluate the exercise-induced thermoregulatory and hepcidin responses under heat condition (35 °C). RESULTS: After the training period, core temperature during HST decreased significantly in the HOT group compared with before the training period (p = 0.004), but not in the CON group. Before the training period, HOT and CON groups showed augmented plasma IL-6 elevation with HST (p = 0.002). However, exercise-induced IL-6 elevations were attenuated following the training period in both groups, with no significant difference between two groups. Serum hepcidin concentrations increased significantly with HST in both groups before and after the training period (p = 0.001). In contrast, there was no significant difference in exercise-induced hepcidin elevation before and after the training period in both groups. CONCLUSIONS: Two weeks of endurance training under heat condition improved thermoregulation, whereas exercise-induced hepcidin elevation under hot environment was not attenuated following the training period." @default.
- W4294816887 created "2022-09-06" @default.
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- W4294816887 date "2022-09-01" @default.
- W4294816887 modified "2023-09-24" @default.
- W4294816887 title "Heat Acclimation Does Not Attenuate Hepcidin Elevation After A Single Session Of Endurance Exercise Under Heat Condition" @default.
- W4294816887 doi "https://doi.org/10.1249/01.mss.0000878924.07694.6d" @default.
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