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- W4294818962 abstract "It is unknown whether true inter-individual response differences (IIRD) exist with respect to changes in anxiety as a result of aerobic exercise training in adults with fibromyalgia (FM). PURPOSE: Determine whether true IIRD exist with respect to changes in anxiety as a result of aerobic exercise training in adults with FM. METHODS: Data from a previous as well as updated meta-analytic database of randomized controlled trials of exercise in adults with arthritis and other rheumatic diseases were sourced. Randomized controlled trials limited to aerobic exercise training on anxiety in adults >18 years of age with FM were included. Change outcome standard deviations treated as point estimates for anxiety were used to calculate true IIRD from each study. In addition, treatment effect data were extracted. The inverse variance heterogeneity (IVhet) model was used to pool all results. RESULTS: For the five studies and 321 participants in which results were pooled, statistically significant treatment effect reductions in anxiety were observed (Mean, -0.77 points, 95% CI, -1.25 to -0.77). However, no significant IIRD were found (Mean, 0.6 points, 95% confidence interval, -1.2 to 1.5). The 95% prediction interval for true IIRD in a future study was -1.7 to 0.8. The percent chance, i.e., probability, of a clinically meaningful difference in variability, i.e., IIRD, was 61.5% (only possibly clinically important). CONCLUSION: While aerobic exercise is associated with reductions in anxiety among adults with fibromyalgia, there is currently a lack of convincing evidence to support the notion that true IIRD exist. Therefore, a search for potential mediators and moderators associated with aerobic exercise and changes in anxiety among adults with FM may not be warranted. However, additional research is needed before any true level of certainty can be established. This includes (1) the assessment of IIRD in future randomized controlled trials, (2) randomized controlled trials of longer duration, and (3) an increase in the proportion of men included in randomized controlled trials." @default.
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- W4294818962 date "2022-09-01" @default.
- W4294818962 modified "2023-09-26" @default.
- W4294818962 title "Inter-individual Differences In Anxiety As A Result Of Aerobic Exercise In Adults With Fibromyalgia: Meta-analysis" @default.
- W4294818962 doi "https://doi.org/10.1249/01.mss.0000877872.40464.54" @default.
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