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- W4294832683 abstract "Summary The development of highly effective malaria vaccines and improving drug treatment protocols to boost anti-parasitic immunity is critical for malaria elimination. However, these efforts are hampered by parasite-specific immunoregulatory networks that are rapidly established following exposure to malaria parasites. Here, we identify stimulator of interferon genes (STING) as a critical mediator of type I interferon production by CD4 + T cells during blood-stage Plasmodium falciparum infection. STING activation by cyclic guanosine monophosphate-adenosine monophosphate (cGAMP) stimulated IFNB gene transcription that promoted development of IL-10 and IFNγ co-producing CD4 + T (type I regulatory; Tr1) cells. CD4 + T cell sensitivity to STING phosphorylation increased in healthy volunteers following P. falciparum infection, particularly in Tr1 cells. Finally, we found the JAK1/2 inhibitor ruxolitinib modulated this innate signalling axis in CD4 + T cells to increase parasite-specific Th1 and diminish Tr1 cell responses. These findings identify STING as a critical mediator of Tr1 cell development during malaria." @default.
- W4294832683 created "2022-09-07" @default.
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- W4294832683 date "2022-09-05" @default.
- W4294832683 modified "2023-10-16" @default.
- W4294832683 title "STING activation promotes autologous type I interferon-dependent development of type 1 regulatory T cells during malaria" @default.
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- W4294832683 doi "https://doi.org/10.1101/2022.09.04.506109" @default.
- W4294832683 hasPublicationYear "2022" @default.
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